摘要：【中文】本申请公开了一种仿生学三相组织工程支架，包括多个支架层，支架层沿纵向叠加，所述支架层包括沿横向依次分布的骨支架、软骨支架和肌腱支架，相邻层的骨支架至少部分相互抵接，相邻层的软骨支架至少部分相互抵接，相邻层的肌腱支架至少部分相互抵接，其中至少两层支架层中的骨支架、软骨支架和肌腱支架的所占区域的位置和/或比例不同。上述方案通过控制各个支架层中的骨支架、软骨支架和肌腱支架所占区域的位置和/或比例，使得由各个支架层叠加得到的工程支架具有仿生特性，可以根据实际组织中骨支架、软骨支架以及肌腱支架的位置和/或比例进行构建，使其具有较为正常的组织型态，而非简单地平齐结构，更加符合人体生理结构。 【EN】The application discloses bionics three-phase tissue engineering support, including a plurality of support layers, the support layer is along vertical stack, the support layer includes bone support, cartilage support and the tendon support that distributes in proper order along transversely, and the mutual butt of bone support part at least of adjacent layer, the mutual butt of cartilage support part at least of adjacent layer, the mutual butt of tendon support part at least of adjacent layer, wherein the position and/or the proportion in the shared region of bone support, cartilage support and tendon support in at least two-layer support layer are different. Above-mentioned scheme is through the position and/or the proportion of the shared region of bone scaffold, cartilage support and tendon support in the control each support layer for the engineering support who obtains by each support layer stack has bionical characteristic, can construct according to the position and/or the proportion of bone scaffold, cartilage support and tendon support in the actual tissue, makes it have comparatively normal tissue form, and not simply parallel and level structure, accords with human physiology structure more.

摘要：【中文】本发明公开了一种用于光固化3D打印的导电光敏树脂，按照质量份数，包括有以下组份：乙烯‑醋酸乙烯共聚物25～40份、聚氨酯丙烯酸酯20～35份、导电填料15～30份、钛酸酯偶联剂1～5份、新戊二醇二丙烯酸酯10～25份、二甲基聚硅氧烷0.5～5份、BYK‑306流平剂0.5～5份、二苯甲酮2～10份。本发明中3D打印的导电光敏树脂是以乙烯‑醋酸乙烯共聚物和聚氨酯丙烯酸酯为基体，并添加了导电填料，同时利用乙烯‑醋酸乙烯共聚物和导电填料的相互作用，进一步增强导电性能，因而本发明的导电光敏树脂不仅保持有快固化效率的同时有很好的导电性。 【EN】The invention discloses a conductive photosensitive resin for photocuring 3D printing, which comprises the following components in parts by weight: 25-40 parts of ethylene-vinyl acetate copolymer, 20-35 parts of urethane acrylate, 15-30 parts of conductive filler, 1-5 parts of titanate coupling agent, 10-25 parts of neopentyl glycol diacrylate, 0.5-5 parts of dimethyl polysiloxane, 0.5-5 parts of BYK-306 flatting agent and 2-10 parts of benzophenone. The conductive photosensitive resin for 3D printing in the invention takes ethylene-vinyl acetate copolymer and polyurethane acrylate as matrixes, conductive filler is added, and the interaction of the ethylene-vinyl acetate copolymer and the conductive filler is utilized to further enhance the conductivity, so that the conductive photosensitive resin not only maintains the fast curing efficiency, but also has good conductivity.

摘要：【中文】本发明涉及一种蛋白降解靶向嵌合体及制备方法和应用，该蛋白降解靶向嵌合体结构如下所示：为含有杂环的连接基团，杂环含有至少一个N原子。该蛋白降解靶向嵌合体将能与靶标CD147蛋白质特异性结合土荆皮乙酸部分和能与E3泛素连接酶结合的沙利度胺部分连接，通过同时作用于靶标蛋白和E3泛素连接酶，将活化的泛素转移至靶标蛋白上，实现了对其选择性泛素化，最终泛素化的靶标蛋白被蛋白酶体识别并降解，在用于制备治疗或预防癌症的药物中，尤其在用于制备以CD147为靶点的抗肿瘤药物中有很高的应用价值。 【EN】The invention relates to a protein degradation targeting chimera, a preparation method and application thereof, wherein the structure of the protein degradation targeting chimera is as follows:is a linking group containing a heterocyclic ring, the heterocyclic ring containing at least one N atom. The protein degradation targeting chimera is connected with a part which can be specifically combined with pseudolaric acid B of a target CD147 protein and a part which can be combined with E3 ubiquitin ligase, activated ubiquitin is transferred to the target protein by simultaneously acting on the target protein and the E3 ubiquitin ligase, selective ubiquitination of the target protein is realized, finally the ubiquitinated target protein is identified and degraded by proteasome, and the protein degradation targeting chimera is used for preparing a medicament for treating or preventing cancerParticularly has high application value in preparing anti-tumor drugs taking CD147 as a target.

摘要：【中文】本发明公开了一种心脑血管病康复装置，包括底座和上肢锻炼装置，底座上端和上肢锻炼装置下端连接，其特征在于：底座上设有下肢锻炼装置，下肢锻炼装置包括支撑部、滚轮、第一轴和脚踏装置，支撑部中间设有第一圆孔，滚轮和第一圆孔配合，滚轮和支撑部转动连接，第一轴和滚轮通过键连接；脚踏装置包括踏杆、踏板轴和踏板，踏杆和第一轴通过键连接，踏板轴一端和踏杆远离第一轴的一端连接，踏板和踏板轴转动连接；脚踏装置和上肢锻炼装置通过连杆装置连接；上肢锻炼装置包括支撑柱、第二轴、连接杆、把手和飞轮，支撑柱上端设有第二圆孔，连接杆的一端和第二轴通过键连接，把手的一端和连接杆远离第二轴的一端连接。 【EN】The invention discloses a cardiovascular and cerebrovascular disease rehabilitation device, which comprises a base and an upper limb exercising device, wherein the upper end of the base is connected with the lower end of the upper limb exercising device, and the cardiovascular and cerebrovascular disease rehabilitation device is characterized in that: the lower limb exercising device is arranged on the base and comprises a supporting part, a roller, a first shaft and a pedal device, wherein a first round hole is formed in the middle of the supporting part, the roller is matched with the first round hole, the roller is rotatably connected with the supporting part, and the first shaft is connected with the roller through a key; the pedal device comprises a pedal rod, a pedal shaft and a pedal, the pedal rod is connected with the first shaft through a key, one end of the pedal shaft is connected with one end of the pedal rod, which is far away from the first shaft, and the pedal is rotatably connected with the pedal shaft; the pedal device is connected with the upper limb exercising device through a connecting rod device; the upper limb exercising device comprises a support column, a second shaft, a connecting rod, a handle and a flywheel, wherein a second round hole is formed in the upper end of the support column, one end of the connecting rod is connected with the second shaft through a key, and one end of the handle is connected with one end of the connecting rod far away from the second shaft.

摘要：【中文】本发明公开了一种癫痫病人用防咬舌装置，包括缓冲垫，缓冲垫一端通过支撑件固定在主体框架上，另一端通过支撑杆与滑块机构相连，滑块机构下设有主体框架，主体框架内设有刻度梁，刻度梁上安装有按压机构。本发明与现有技术相比的优点在于：缓冲垫及主体框架外包裹有橡胶套，可以极大避免整体对癫痫病人口腔的物理撞击，提高安全性，通过可调节的滑块机构和按压机构的配合工作，医务人员可根据癫痫病人口腔的不同形状，调节缓冲垫的位置，保护癫痫病人的舌头不被牙齿咬伤，滤网的设计可避免癫痫病人发病时产生太多的唾液涌入喉咙甚至器官，整体结构简单精巧，无易损件，外形美观大方，实用性强，使用寿命长，安全性能优良。 【EN】The invention discloses a tongue biting prevention device for an epileptic patient, which comprises a cushion pad, wherein one end of the cushion pad is fixed on a main body frame through a support piece, the other end of the cushion pad is connected with a sliding block mechanism through a support rod, the main body frame is arranged below the sliding block mechanism, a scale beam is arranged in the main body frame, and a pressing mechanism is arranged on the scale beam. Compared with the prior art, the invention has the advantages that: the outer parcel of blotter and main body frame has the rubber sleeve, can greatly avoid whole physical striking to epileptic patient's oral cavity, the security is improved, cooperation work through adjustable slider mechanism and pressing means, medical staff can be according to the different shapes in epileptic patient's oral cavity, adjust the position of blotter, protect epileptic patient's tongue not bitten by the tooth, the design of filter screen can produce too much saliva when epileptic patient breaks a disease and gush into throat or organ even, the overall structure is simple exquisite, no wearing parts, appearance elegant appearance, therefore, the clothes hanger is strong in practicability, long service life, and is excellent in safety performance.

摘要：【中文】本发明涉及一种脑血管用吸氧装置，包括呼吸机、用于支撑颈部的曲板和为病人供氧的供氧装置；呼吸机包括显示屏、第一旋钮、第二旋钮、供电接口和供氧接口；曲板包括扩口部、窄口部、弧形部、加热部和供电线；供氧装置包括供氧管、湿化瓶和吸氧管。曲板可以对病人颈部起到支撑作用，抬高病人的颈部，防止病人呼吸道受到压迫，保持病人呼吸道通畅，便于病人吸入更多氧气；同时曲板弧形部采用与颈椎生理曲度相同的设计，可以增加病人使用时的舒适度。曲板上的加热部可以提高病人颈部的温度，改善颈部的血液循环，提高颈动脉对脑部的供血量，增加脑部的供氧量。本发明使用方便，效果良好，成本低，可以广泛应用在医疗器械领域。 【EN】The invention relates to an oxygen inhalation device for cerebral vessels, which comprises a breathing machine, a curved plate for supporting the neck and an oxygen supply device for supplying oxygen to patients; the breathing machine comprises a display screen, a first knob, a second knob, a power supply interface and an oxygen supply interface; the curved plate comprises a flared part, a narrow part, an arc part, a heating part and a power supply line; the oxygen supply device comprises an oxygen supply pipe, a humidifying bottle and an oxygen absorption pipe. The bent plate can support the neck of a patient, so that the neck of the patient is lifted, the respiratory tract of the patient is prevented from being pressed, the respiratory tract of the patient is kept smooth, and the patient can conveniently inhale more oxygen; meanwhile, the arc-shaped part of the bent plate adopts the design the same as the physiological curvature of the cervical vertebra, so that the comfort degree of a patient in use can be improved. The heating part on the curved plate can increase the temperature of the neck of a patient, improve the blood circulation of the neck, increase the blood supply of the carotid artery to the brain and increase the oxygen supply of the brain. The invention has convenient use, good effect and low cost, and can be widely applied to the field of medical instruments.

摘要：【中文】本发明公开了一种个体化肘关节稳定器及其制作方法，个体化肘关节稳定器包括用于贯穿连接尺骨和肱骨的轴部和与轴部相连的固定部，固定部上设有两个以上用于穿过螺钉将个体化肘关节稳定器固定到尺骨上的安装孔。制作方法包括采集患者CT影像数据建模得到肘关节三维模型、采用3D打印设备打印获得1:1患肘关节模型、依据患肘关节模型制作出个体化肘关节稳定器的步骤。本发明适用于内固定方式稳定肘关节，具有个体化、结构简单、成本低、装卸简便、固定稳定可靠、可减少并发症发生等优点。 【EN】The invention discloses an individualized elbow joint stabilizer and a manufacturing method thereof. The manufacturing method comprises the steps of acquiring CT image data of a patient, modeling to obtain an elbow joint three-dimensional model, printing by adopting 3D printing equipment to obtain a 1:1 elbow joint model, and manufacturing the individualized elbow joint stabilizer according to the elbow joint model. The invention is suitable for stabilizing the elbow joint in an internal fixing mode, and has the advantages of individuation, simple structure, low cost, simple and convenient assembly and disassembly, stable and reliable fixation, capability of reducing the occurrence of complications and the like.

摘要：【中文】本发明涉及一种血液透析浓缩液配制装置，包括配液桶和桶盖，桶盖上设有进料口和进液管道以及消毒液管道，进液管道伸入配液桶的末端设有导流管，导流管紧贴配液桶内壁，配液桶内部上端沿配液桶内壁设有一圈环形管道，环形管道上开设有多个出液孔，消毒液管道与环形管道连接；配液桶另一侧设有鼓风机，鼓风机通过风路管道与配液桶连接，且与配液桶的连接处设有第一单向阀门，鼓风机出风口设有第二单向阀门，风路管道上设有空气滤芯。 【EN】The invention relates to a hemodialysis concentrated solution preparation device, which comprises a solution preparation barrel and a barrel cover, wherein the barrel cover is provided with a feed inlet, a liquid inlet pipeline and a disinfectant pipeline; the other side of the liquid preparation barrel is provided with a blower, the blower is connected with the liquid preparation barrel through an air path pipeline, a first one-way valve is arranged at the joint of the blower and the liquid preparation barrel, the air outlet of the blower is provided with a second one-way valve, and an air filter element is arranged on the air path pipeline.

摘要：【中文】本发明公开了一种可准确控制压强差的胸外科防堵引流装置，具体涉及胸外科防堵引流装置领域，包括引流管和收集箱，所述引流管固定设于收集箱一端，所述引流管包括一号导管、二号导管和三号导管，所述二号导管固定设于一号导管与三号导管之间，所述一号导管与二号导管之间固定设有一号连接囊，所述二号导管与三号导管之间固定设有二号连接囊，所述二号导管中部固定设有处理筒，所述一号导管、二号导管和三号导管均包括支撑片及软胶管，且软胶管固定设于支撑片侧面，所述一号连接囊的内壁顶部和二号连接囊的内壁顶部均固定设有垫片。本发明可防止弯折过度而堵塞，便于夹紧停止引流，结构简单，使用方便，可准确控制压强差。 【EN】The invention discloses a thoracic surgery anti-blocking drainage device capable of accurately controlling pressure difference, and particularly relates to the field of thoracic surgery anti-blocking drainage devices. The invention can prevent blockage caused by excessive bending, is convenient for clamping and stopping drainage, has simple structure and convenient use, and can accurately control the pressure difference.

摘要：【中文】本发明涉及一种针对Fyn‑CD147信号通路靶点的抗肿瘤化合物及其制备方法和应用，所述抗肿瘤化合物具有如下结构式I表示的结构。本发明的抗肿瘤化合物通过3‑羟基苯乙酮和4‑溴‑3,5‑二甲氧基苯甲醛，在醇和醇钠的催化下反应生成。该抗肿瘤化合物可有效地抑制皮肤肿瘤细胞、结肠癌细胞、肝癌细胞及肺癌细胞的增殖，其中对于人皮肤恶性黑色素瘤细胞SK‑Mel‑5和SK‑Mel‑28的半抑制浓度分别为0.8956μM和0.8257μM，说明该抗肿瘤化合物抑制肿瘤的生长和增殖、诱导肿瘤细胞凋亡的能力较强，可应用于制备抗肿瘤药物。 【EN】The invention relates to an anti-tumor compound aiming at Fyn-CD147 signal channel targets, and a preparation method and application thereof. The anti-tumor compound is prepared by reacting 3-hydroxyacetophenone and 4-bromo-3, 5-dimethoxybenzaldehyde under the catalysis of alcohol and sodium alcoholate. The antitumor compound can effectively inhibit the proliferation of skin tumor cells, colon cancer cells, liver cancer cells and lung cancer cells, wherein the half inhibition concentrations of the human skin malignant melanoma cells SK-Mel-5 and SK-Mel-28 are 0.8956 mu M and 0.8257 mu M respectively, which shows that the antitumor compound can inhibit the growth and proliferation of tumors and induce the tumorsHas strong apoptosis ability, and can be used for preparing antitumor drugs.