摘要：【中文】本发明涉及生物医学领域，具体而言，用于指导肾病综合征CYP3A5表达型患儿使用他克莫司的多态性位点。所多态性位点为MAP3K11rs7946115、MYH9rs2239781以及CTLA4rs4553808位点中的至少一种。中三个位点与肾病综合征CYP3A5表达型患儿的他克莫司药动学密切相关，且其检测属于外周血指标，可方便获取，方便将来推广使用。 【EN】The invention relates to the field of biomedicine, in particular to a method for guiding nephrotic syndrome CYP3A5 expression children to use tacrolimus polymorphic sites. The polymorphic site is at least one of MAP3K11rs7946115, MYH9rs2239781 and CTLA4rs4553808 sites. The three middle sites are closely related to tacrolimus pharmacokinetics of a nephrotic syndrome CYP3A5 expression infant patient, and detection of the tacrolimus pharmacokinetics belongs to peripheral blood indexes, so that the tacrolimus pharmacokinetic diagnosis kit can be conveniently obtained and is convenient to popularize and use in the future.

摘要：【中文】本发明涉及生物医学领域，具体而言，用于指导肾病综合征CYP3A5非表达型患儿使用他克莫司的多态性位点。所多态性位点为IL2RA rs12722489、MYH9 rs2239781、MYH9 rs4821478、ACTN4 rs56113315、ACTN4 rs62121818、ACTN4 rs3745859以及INF2 rs1128880位点中的至少一种。这些位点与肾病综合征CYP3A5非表达型患儿的他克莫司药动学密切相关，且其检测属于外周血指标，可方便获取，方便将来推广使用。 【EN】The invention relates to the field of biomedicine, in particular to a method for guiding nephrotic syndrome CYP3A5 non-expression children to use tacrolimus polymorphic sites. The polymorphic site is at least one of IL2RA rs12722489, MYH9rs2239781, MYH9rs4821478, ACTN4rs56113315, ACTN4rs62121818, ACTN4rs3745859 and INF2rs1128880 sites. The sites are closely related to tacrolimus pharmacokinetics of nephrotic syndrome CYP3A5 non-expression children patients, and detection of the sites belongs to peripheral blood indexes, so that the sites can be conveniently obtained and are convenient to popularize and use in the future.

摘要：【中文】本发明涉及生物医学领域，具体而言，涉及MYH9及CTLA4基因多态性位点在指导肾病综合征患儿使用他克莫司中的应用。所述MYH9基因多态性位点为rs2239781，所述CTLA4基因多态性位点为rs4553808。MYH9rs2239781和CTLA4rs4553808位点与肾病综合征患儿的他克莫司药动学密切相关，且其检测属于外周血指标，可方便获取，方便将来推广使用。 【EN】The invention relates to the field of biomedicine, in particular to application of MYH9 and CTLA4 gene polymorphic sites in guiding children with nephrotic syndrome to use tacrolimus. The MYH9 gene polymorphism site is rs2239781, and the CTLA4 gene polymorphism site is rs 4553808. MYH9rs2239781 and CTLA4rs4553808 loci are closely related to tacrolimus pharmacokinetics of children with nephrotic syndrome, and detection of the loci belongs to peripheral blood indexes, so that the loci can be obtained conveniently and are convenient to popularize and use in the future.

摘要：【中文】本发明公开了一种用于植入受试者皮下组织的新血管构建体及其制备方法，涉及高分子材料技术领域。该新血管构建体为所述高分子材料通过静电纺丝的方式制得的纳米纤维导管，材料选自左旋聚乳酸、右旋聚乳酸、聚乳酸羟基乙酸共聚物和聚羟基乙酸中的一种，采用该高分子材料制备的血管构建体移植入皮下组织，可快速在受试者皮下形成一个富含新血管的细胞外基质空间，用于容纳供体来源的胰岛或胰岛细胞长期维持功能。 【EN】The invention discloses a neovascular construct for being implanted into subcutaneous tissues of a subject and a preparation method thereof, and relates to the technical field of high polymer materials. The new blood vessel construct is a nano fiber conduit made of the high polymer material in an electrostatic spinning mode, the material is selected from one of levorotatory polylactic acid, dextrorotatory polylactic acid, polylactic-co-glycolic acid and polyglycolic acid, the blood vessel construct made of the high polymer material is transplanted into subcutaneous tissue, and an extracellular matrix space rich in new blood vessels can be rapidly formed under the skin of a subject, so that the new blood vessel construct is used for accommodating islet or islet cells from a donor source to maintain the function for a long time.

摘要：【中文】本发明公开了一种组织工程化尿道支架移植物及其制备方法和应用，涉及组织工程技术领域，该组织工程化尿道支架移植物为接种有上皮细胞和平滑肌细胞的高分子可降解纳米纤维管，所述上皮细胞为含有单能分化潜能的上皮祖细胞的上皮细胞，该纳米纤维管的降解速率可与尿道修复的再生速率匹配，能有效修复尿道损伤。 【EN】The invention discloses a tissue-engineered urethral stent graft and a preparation method and application thereof, relating to the technical field of tissue engineering.

摘要：【中文】本发明涉及一种构建神经母细胞瘤模型的方法、装置、计算机设备和存储介质。所述方法包括：获取第一STL文档和第二STL文档；所述第一STL文档用于表征神经母细胞瘤的信息；所述第二STL文档用于表征所述神经母细胞瘤的周围组织的信息；将预先选取的颜色信息添加至所述第一STL文档和所述第二STL文档中；若接收到整合指令，对包含有颜色信息的第一STL文档和第二STL文档进行整合处理，得到整体STL文档；根据所述整体STL文档，打印得到有色整体模型；所述有色整体模型为包含有所述神经母细胞瘤和所述周围组织的模型。采用本方法能够准确呈现神经母细胞瘤和其他组织位置关系。 【EN】The invention relates to a method, an apparatus, a computer device and a storage medium for constructing a neuroblastoma model. The method comprises the following steps: acquiring a first STL document and a second STL document; the first STL document is used to characterize information of a neuroblastoma; the second STL document is used to characterize information of surrounding tissue of the neuroblastoma; adding pre-selected color information to the first and second STL documents; if an integration instruction is received, integrating the first STL document and the second STL document containing the color information to obtain an integral STL document; printing to obtain a colored integral model according to the integral STL document; the colored integral model is a model comprising the neuroblastoma and the surrounding tissue. The method can accurately present the position relation of the neuroblastoma and other tissues.

摘要：【中文】本发明属于生物技术领域，具体涉及髓系细胞触发受体1在制备胃炎诊断或治疗试剂中的应用及试剂盒。本发明公开了检测髓系细胞触发受体1的试剂在制备用于胃炎的诊断和/或预后的诊断剂中的应用；该髓系细胞触发受体1来源于单核‑巨噬细胞。本发明还提供了一种胃炎诊断和/或预后试剂盒，该试剂盒包括能够检测所述髓系细胞触发受体1的表达的试剂。本发明还提供了髓系细胞触发受体1在制备用于预防和/或治疗胃炎的药物中的应用。将髓系细胞触发受体1用于胃炎诊断和治疗，具有简便、快捷、创伤小、易复查等优点，应用前景广阔。 【EN】The invention belongs to the technical field of biology, and particularly relates to application of a myeloid cell trigger receptor 1 in preparation of a reagent for diagnosing or treating gastritis and a kit. The invention discloses an application of a reagent for detecting a myeloid cell triggering receptor 1 in preparing a diagnostic agent for diagnosis and/or prognosis of gastritis; the myeloid-lineage cell-triggering receptor 1 is derived from monocyte-macrophages. The invention also provides a gastritis diagnosis and/or prognosis kit, which comprises a reagent capable of detecting the expression of the myeloid lineage cell trigger receptor 1. The invention also provides application of the myeloid cell triggering receptor 1 in preparing a medicament for preventing and/or treating gastritis. The myeloid cell trigger receptor 1 is used for diagnosing and treating gastritis, has the advantages of simplicity, convenience, rapidness, small wound, easiness in rechecking and the like, and has a wide application prospect.

摘要：【中文】本申请涉及一种构建遗传亚型预测模型的方法、装置、计算机设备和存储介质。所述方法包括：接收训练样本的基因表达谱和对应的遗传亚型；按照预先确定的分类个数，对所述基因表达谱进行分类整合，得到目标基因表达谱；所述目标基因表达谱包括与所述分类个数对应的类别；从所述目标基因表达谱的类别中，选取目标类别，构建所述目标类别和所述遗传亚型的对应关系；根据所述对应关系，输出遗传亚型预测模型。采用本方法能够基于在基因表达谱和遗传亚型之间构建的灵活的对应关系，得到遗传亚型预测模型。 【EN】The present application relates to a method, apparatus, computer device and storage medium for constructing a genetic subtype prediction model. The method comprises the following steps: receiving a gene expression profile and a corresponding genetic subtype of a training sample; classifying and integrating the gene expression profiles according to the predetermined classification number to obtain target gene expression profiles; the target gene expression profile comprises categories corresponding to the classification numbers; selecting a target class from the classes of the target gene expression profile, and constructing a corresponding relation between the target class and the genetic subtype; and outputting a genetic subtype prediction model according to the corresponding relation. By adopting the method, the genetic subtype prediction model can be obtained based on the flexible corresponding relation constructed between the gene expression profile and the genetic subtype.

摘要：【中文】本发明公开LAP3作为儿童腺病毒肺炎诊断标志物的应用。发明人研究发现，LAP3可以很好地区分儿童腺病毒肺炎和正常儿童，通过定量LAP3在儿童血清中的表达情况，有可能得到快速、简便地对儿童腺病毒肺炎进行诊断。为儿童腺病毒肺炎引起的难治疗提供早期诊断，尽快控制病毒，为完全治愈提供诊断依据。 【EN】The invention discloses application of LAP3 as a diagnosis marker of children adenovirus pneumonia. The inventor researches and discovers that the LAP3 can well distinguish children adenovirus pneumonia from normal children, and the children adenovirus pneumonia can be quickly and simply diagnosed by quantifying the expression condition of the LAP3 in the serum of the children. Provides early diagnosis for the difficult treatment caused by the children adenovirus pneumonia, controls the virus as soon as possible and provides a diagnosis basis for complete cure.

摘要：【中文】本发明公开一种高分子医疗产品表面强界面粘结亲水润滑涂层的制备方法，包括以下步骤：（1）高分子医疗产品表面氧等离子体处理；（2）偶联剂分子表面接枝；（3）润滑涂层溶液的配置；（4）润滑涂层在高分子医疗产品表面的化学交联。本发明制备的界面粘结亲水润滑涂层生物相容性良好，亲水性及润滑性优异，同时与高分子医疗产品表面界面结合牢固，可广泛用于高分子医疗产品比如呼吸道、消化道、直肠等的医用导管润滑，有效保护腔道内壁，降低患者在使用过程中的不适感或疼痛感。 【EN】The invention discloses a preparation method of a hydrophilic lubricating coating bonded on a strong interface of the surface of a polymer medical product, which comprises the following steps: (1) oxygen plasma treatment is carried out on the surface of the polymer medical product; (2) grafting the surface of coupling agent molecule; (3) preparing a lubricating coating solution; (4) chemical crosslinking of the lubricating coating on the surface of the polymeric medical product. The interface bonding hydrophilic lubricating coating prepared by the invention has good biocompatibility, excellent hydrophilicity and lubricity, and firm combination with the surface interface of a polymer medical product, can be widely used for lubricating medical catheters of polymer medical products such as respiratory tracts, digestive tracts, rectum and the like, effectively protects the inner wall of a cavity, and reduces the discomfort or pain of patients in the using process.