摘要：【中文】本发明公开了一种手性β‑羟基酰胺类化合物及其制备方法。该化合物如式I所示。本发明提供的制备非天然手性氨基酸类合物的原料是用红球菌Rhodococcus erythropolis AJ270微生物体系催化水解带有不同取代基的前手性二酰胺类化合物II得到。所用红球菌菌体用量可根据底物的用量来进行调节。反应溶剂为pH值6.0‑8.0的常用缓冲溶液，温度为20‑37℃，反应时间为3‑120小时。该红球菌微生物催化体系具有可发酵培养和保存方便的特点。运用此生物转化制备手性单酰胺羧酸、二羧酸的方法，具有操作简便，反应高效，反应条件温和，对映选择性高，产物易分离，产物纯度高的特点，具有很好的应用前景。 【EN】The invention discloses a chiral β -hydroxy amide compound and a preparation method thereof, wherein the compound is shown as a formula I, and the raw material for preparing the non-natural chiral amino acid compound provided by the invention is Rhodococcus erythropolis AJ270The microbial system catalyzes and hydrolyzes prochiral diamide compounds II with different substituents to obtain the compound. The dosage of the rhodococcus thallus can be adjusted according to the dosage of the substrate. The reaction solvent is common buffer solution with pH value of 6.0-8.0, the temperature is 20-37 ℃, and the reaction time is 3-120 hours. The Rhodococcus microorganism catalysis system has the characteristics of fermentation culture and convenient preservation. The method for preparing the chiral monoamide carboxylic acid and the chiral dicarboxylic acid by biotransformation has the characteristics of simple and convenient operation, high reaction efficiency, mild reaction conditions, high enantioselectivity, easy separation of products and high product purity, and has good application prospect.

摘要：【中文】本文提供了一种具有低蛋白吸附性能的胶体颗粒及其制备方法和用途；所述胶体颗粒具有操作制备步骤简单、反应条件温和、良好的抗蛋白质吸附性能以及良好的生物相容性等特点。具体为：把高分子链本身的抗蛋白质吸附性能，与表面凹陷尺寸对所吸附蛋白质的选择性结合起来，通过二者的协同作用，实现材料对蛋白质吸附量的进一步降低。材料可选范围大，有利于引入生物相容性组分。本文的胶体颗粒可以是具有空腔结构的，其可以作为药物载体，或其他小分子试剂的载体，将客体分子运输到靶向位置，实现材料对药物运输和释放药物的功能。 【EN】Provided herein are colloidal particles having low protein adsorption properties, methods of making and uses thereof; the colloidal particles have the characteristics of simple operation and preparation steps, mild reaction conditions, good protein adsorption resistance, good biocompatibility and the like. The method specifically comprises the following steps: the protein adsorption resistance of the high molecular chain is combined with the selectivity of the surface depression size to the adsorbed protein, and the further reduction of the protein adsorption amount of the material is realized through the synergistic effect of the protein adsorption resistance and the surface depression size. The material has wide selectable range, and is beneficial to introducing biocompatible components. The colloidal particles can be in a cavity structure, and can be used as a drug carrier or a carrier of other small molecule reagents to transport guest molecules to a target position, so that the functions of the material on drug transportation and drug release are realized.

摘要：【中文】本发明提供了一种有机共晶增益材料及其制备方法和在激光性能中的应用，所述有机共晶增益材料的分子间相互作用的不同导致他们组装成特定的微纳结构(例如微米片、微米环)；所述具有特定微纳结构的有机共晶增益材料可作为高质量的光学谐振腔体，为共晶的受激辐射提供光学反馈和模式选择；所述有机共晶增益材料的卤键间的相互作用，仅仅带来了微弱的电荷转移，从而在共晶中保留了有利的四能级结构以实现最终的激光辐射；同时，改变卤键给体可调控所述有机共晶增益材料的分子间相互作用，进而改变组装结构和能级结构，最终实现对共晶激光性质的调控。在所述材料中首次实现了共晶的光泵浦激光辐射，并且通过改变卤键给体调节激光性质。 【EN】The invention provides an organic eutectic gain material, a preparation method thereof and application thereof in laser performance, wherein the organic eutectic gain material is assembled into a specific micro-nano structure (such as a micron sheet and a micron ring) due to different intermolecular interactions; the organic eutectic gain material with the specific micro-nano structure can be used as a high-quality optical resonance cavity to provide optical feedback and mode selection for stimulated radiation of eutectic; the interaction between halogen bonds of the organic eutectic gain material only brings weak charge transfer, so that a favorable four-level structure is reserved in the eutectic to realize final laser radiation; meanwhile, the halogen bond donor is changed to regulate and control the intermolecular interaction of the organic eutectic gain material, so that the assembly structure and the energy level structure are changed, and finally the regulation and control of the eutectic laser property are realized. Eutectic optically pumped laser irradiation is achieved for the first time in the material and the laser properties are adjusted by changing the halogen bond donor.

摘要：【中文】本发明公开了一种氮膦配体配位型三氟甲氧基化试剂及其制备方法和应用。本发明如I所示的氮膦配体配位型三氟甲氧基化试剂，实现了直接以一级或二级对硝基苯磺酸酯为底物来制备三氟甲氧基类化合物。如I所示的氮膦配体配位型三氟甲氧基化试剂在S_N2亲核取代反应中，可抑制单氟取代的副产物的生成，以良好的收率得到了具有高度立体专一性的光学活性的三氟甲氧基类化合物。 【EN】The invention discloses a nitrogen-phosphine ligand coordination type trifluoromethoxy reagent and a preparation method and application thereof. The nitrogen phosphine ligand coordination type trifluoromethoxy reagent disclosed by the invention realizes the preparation of a trifluoromethoxyl compound by directly using first-order or second-order p-nitrobenzenesulfonate as a substrate. The nitrogen-phosphine ligand coordination type trifluoromethoxy reagent shown as I is in S_N2, the formation of monofluoro substituted by-products can be suppressed in nucleophilic substitution reaction, and the optically active trifluoromethoxys compound with high stereospecificity can be obtained with good yield.

摘要：【中文】一种有机荧光传感材料，其由式(A)所示的咔唑衍生物与式(I)所示的芴衍生物共组装形成。所述有机荧光传感材料可克服单一使用式(A)化合物时检测灵敏性差和单一使用式(I)时稳定性差的问题。具体为，本发明采用共组装可以有效地集合不同分子的优点，引入抗氧化的分子(式(I)所示化合物)与检测性能优异的分子(式(A)所示化合物)共组装得到的材料可以很好地解决材料稳定性的问题，并同时保持对爆炸物的高灵敏度检测。 【EN】An organic fluorescent sensing material is formed by co-assembling carbazole derivatives shown in a formula (A) and fluorene derivatives shown in a formula (I). The organic fluorescent sensing material can overcome the problems of poor detection sensitivity when the compound shown in the formula (A) is singly used and poor stability when the compound shown in the formula (I) is singly used. Specifically, the invention adopts co-assembly to effectively integrate the advantages of different molecules, and the material obtained by co-assembling the antioxidant molecule (the compound shown in the formula (I)) and the molecule with excellent detection performance (the compound shown in the formula (A)) can well solve the problem of material stability and simultaneously keep high sensitivity detection on explosives.

摘要：【中文】本发明采用式(A)和式(B)两种分子结构作为构筑单元，通过分子之间的π‑π相互作用共组装得到新的荧光材料，所述荧光材料能与可挥发性有机苯系物相互作用，出现明显的荧光增强的现象。由式(A)所示化合物和式(B)所示化合物共组装得到的荧光材料检测有机苯系物时，具有操作简便、响应灵敏、信号反应快、检测特异性、制成小的荧光器件、便于携带的优势。 【EN】The invention adopts two molecular structures of a formula (A) and a formula (B) as a construction unit, and obtains a new fluorescent material through pi-pi interaction and co-assembly between molecules, wherein the fluorescent material can interact with a volatile organic benzene series to generate an obvious fluorescence enhancement phenomenon. When the fluorescent material obtained by co-assembling the compound shown in the formula (A) and the compound shown in the formula (B) is used for detecting the organic benzene series, the fluorescent material has the advantages of simple and convenient operation, sensitive response, quick signal reaction, detection specificity, small fluorescent device and portability.

摘要：【中文】本发明提供了一种由如下式(I)所示化合物和式(II)所示化合物通过共组装得到的有机荧光传感材料。本发明所述有机荧光传感材料通过使用两种不同结构的化合物进行共组装，克服单一使用式(I)化合物时检测不稳定和单一使用式(II)化合物检测的不灵敏。共组装的得到的材料具有比表面积大，表面孔隙多等特征，有利于降低检出限。 【EN】The invention provides an organic fluorescent sensing material obtained by co-assembling a compound shown as a formula (I) and a compound shown as a formula (II). The organic fluorescent sensing material disclosed by the invention is prepared by co-assembling two compounds with different structures, so that the instability of detection when the compound shown in the formula (I) is singly used and the insensitivity of detection when the compound shown in the formula (II) is singly used are overcome. The co-assembled material has the characteristics of large specific surface area, more surface pores and the like, and is favorable for reducing the detection limit.

摘要：【中文】本发明涉及一种N‑叠氮乙酰‑D‑甘露糖胺衍生物及其制备方法和应用。所述化合物的结构如通式(I)所示，其中，R₁选自为O、S、NH、NMe、‑CH＝CH‑；R₃选自为O、S、NH、NMe；R₂选自为H、F、Cl、Br、I、‑OH、‑NH₂、C_1‑6烷基、C_1‑6烷氧基、‑CO‑C_1‑6烷基、‑CO‑NH‑C_1‑6烷基、‑COOC_1‑6烷基、芳基、芳氧基、杂芳基、杂芳氧基、杂环基、杂环氧基；m选自为1‑4的整数；A选自式(I)所述化合物与硝基还原酶发生催化还原反应之后可自行消除或裂解的基团；表示a键或e键。本发明还提供式(I)所示化合物的制备方法和在检测硝基还原酶中的应用。 【EN】The invention relates to an N-azido acetyl-D-mannosamine derivative, a preparation method and application thereof. The structure of the compound is shown as a general formula (I), wherein R₁Selected from O, S, NH, NMe, -CH ═ CH —; r₃Selected from O, S, NH, NMe; r₂Selected from H, F, Cl, Br, I, -OH, -NH₂、C_1‑6Alkyl radical, C_1‑6Alkoxy, -CO-C_1‑6Alkyl, -CO-NH-C_1‑6Alkyl, -COOC_1‑6Alkyl, aryl, aryloxy, heteroaryl, heteroaryloxy, heterocyclyl, heterocyclyloxy; m is selected from integers of 1-4; a is selected from the compounds of formula (I)A group which can be eliminated or cracked by itself after the object and nitroreductase undergo catalytic reduction reaction;represents an a-key or an e-key. The invention also provides a preparation method of the compound shown in the formula (I) and application of the compound in detection of nitroreductase.

摘要：【中文】本发明涉及涉及N‑叠氮基乙酰‑D‑甘露糖胺衍生物在检测酯酶中的应用。本发明主要涉及如下式(I)所示的N‑叠氮基乙酰‑D‑甘露糖胺衍生物及其制备方法和在检测酯酶中的应用：其中，R₁选自为H、F、Cl、Br、I、‑OH、‑NH₂、‑NO₂、‑N₃、C_1‑6烷基、C_1‑6烷氧基、‑CO‑C_1‑6烷基、‑CO‑NH‑C_1‑6烷基、‑COOC_1‑6烷基、芳基、芳基氧基、杂芳基、杂芳基氧基、杂环基、杂环基氧基；所述芳基、芳基氧基、杂芳基、杂芳基氧基、杂环基、杂环基氧基任选被如下基团取代：F、Cl、Br、I、‑OH、‑NH₂、‑NO₂、‑N₃、C_1‑6烷基、C_1‑6烷氧基；R₂、R₃相同或不同，彼此独立地选自为O、S、NH、NMe；n₁、n₂相同或不同，彼此独立地选自为1‑4的整数；表示a键或e键。 【EN】The invention relates to application of N-azidoacetyl-D-mannosamine derivatives in detecting esterase. The invention mainly relates to an N-azido acetyl-D-mannosamine derivative shown as the following formula (I), a preparation method and application thereof in esterase detection:wherein R is₁Selected from H, F, Cl, Br, I, -OH, -NH₂、‑NO₂、‑N₃、C_1‑6Alkyl radical, C_1‑6Alkoxy, -CO-C_1‑6Alkyl, -CO-NH-C_1‑6Alkyl radical、‑COOC_1‑6Alkyl, aryl, aryloxy, heteroaryl, heteroaryloxy, heterocyclyl, heterocyclyloxy; said aryl, aryloxy, heteroaryl, heteroaryloxy, heterocyclyl, heterocyclyloxy optionally substituted with: F. cl, Br, I, -OH, -NH₂、‑NO₂、‑N₃、C_1‑6Alkyl radical, C_1‑6An alkoxy group; r₂、R₃Identical or different, independently of one another, from the group consisting of O, S, NH, NMe; n is₁、n₂Identical or different, independently of one another, from the group consisting of integers from 1 to 4;represents an a-key or an e-key.

摘要：【中文】本发明公开了一类促进水滴在超疏水表面撞击完全铺展的高效铺展剂。该铺展剂由离子性单链表面活性剂和与表面活性剂所带电荷相反的小分子组成。对于阴离子表面活性剂，表面活性剂的含量为0.25％‑2.00％，小分子的浓度为0.10％‑1.00％；对于阳离子表面活性剂，表面活性剂的含量为0.50％‑2.00％，小分子的浓度为0.25％‑1.00％。本发明利用带电小分子与表面活性剂之间的静电相互作用，从而显著降低表面活性剂的临界聚集浓度，平衡表面张力和动态表面张力、以及利用小分子诱导表面活性剂形成的丰富聚集体，改变溶液的流体动力学性质，从而实现水滴撞击超疏水表面时的完全铺展，而抑制水滴的弹射和溅射行为。 【EN】The invention discloses a high-efficiency spreading agent for promoting water drops to completely spread by impacting on a super-hydrophobic surface. The spreading agent consists of an ionic single-chain surfactant and a small molecule with charges opposite to those of the surfactant. For anionic surfactant, the content of the surfactant is 0.25% -2.00%, and the concentration of the micromolecules is 0.10% -1.00%; for cationic surfactants, the surfactant content is 0.50% -2.00% and the small molecule concentration is 0.25% -1.00%. The invention utilizes the electrostatic interaction between the charged micromolecules and the surfactant, thereby obviously reducing the critical aggregation concentration of the surfactant, balancing the surface tension and the dynamic surface tension, and utilizing the micromolecules to induce rich aggregates formed by the surfactant, changing the hydrodynamic property of the solution, realizing the complete spreading when water drops impact the super-hydrophobic surface, and inhibiting the ejection and sputtering behaviors of the water drops.