摘要：本发明属于RNA干扰技术领域，公开了含自由三磷酸基团的TGF-β特异性siRNA及其应用。该含自由三磷酸基团的TGF-β特异性siRNA的反义链和正义链序列5’端均为鸟嘌呤核苷，该鸟嘌呤核苷的戊糖3’位点上修饰有一个自由三磷酸基团。本发明siRNA结合了TGF-β特异性基因沉默作用机制和诱导真核细胞抗病毒的固有免疫作用机制，不仅能抑制介导肿瘤免疫逃逸的重要分子TGF-β，还能有效激活机体的抗肿瘤免疫，能显著性地提高治疗肿瘤的效果。有效地解决了传统siRNA(OH-RNA)仅有单一基因沉默功能，而治疗肿瘤疗效不佳的问题。本发明ppp-TGF-β可在制备治疗肿瘤特别是胰腺癌的药物中应用。

摘要：本发明涉及一种基于网络与中文短信控制的强震数据采集与烈度记录器，包括数据采集系统、触发系统、存储系统、时间系统、数据传输通信系统和控制系统，在记录器中内置嵌入式自适应网络接口芯片和支持中文短信收发的嵌入式GSM通信模块，网络通信接口具有自动监测网络连接状态的能力，可在网络无法连接时，自动定时重新检查网络与记录器之间的网络连接，保证数据传输稳定可靠，提高了强震记录器的数据传输稳定性，利用手机中文短信实现记录器状态检查、传感器标定、功能设定、烈度速报的功能。本发明可高效灵活地通过网络或中文短信进行强震数据采集和实时监控强震记录器仪器状态，扩大仪器应用范围和可靠性。

摘要：【中文】一种油气管道不动火安全封堵装置，包括两组密封连接器和中间连接管；每组密封连接器包括有密封胶圈、固定压盖和密封胶垫，固定压盖的一侧内壁上开设有两个密封胶圈环腔和一个注胶腔，固定压盖上开设有注胶孔与注胶腔连通，注胶孔上安装单向注胶嘴；固定压盖的内侧具有连接螺孔；中间连接管的两端具有外螺纹；两个密封胶圈环腔中均安装密封胶圈，两组密封连接器位于中间连接管两侧相对设置，集油管线穿过固定压盖内的密封胶圈，中间连接管的两端分别螺接在两个固定压盖的连接螺孔中，中间连接管的端口与集油管线的端口之间设置密封胶垫；密封胶圈环腔内注入有耐压耐腐蚀的化学密封胶。利用机械密封和化学密封进行有效的密封，施工安全。 【EN】A kind of oil gas pipeline does not fire the safe plugging device, including two groups of sealed connectors and middle connecting pipe; each group of sealing connectors comprises a sealing rubber ring, a fixed gland and a sealing rubber pad, wherein two sealing rubber ring annular cavities and a rubber injection cavity are formed in the inner wall of one side of the fixed gland; the inner side of the fixed gland is provided with a connecting screw hole; the two ends of the middle connecting pipe are provided with external threads; sealing rubber rings are respectively arranged in the two sealing rubber ring annular cavities, two groups of sealing connectors are positioned on two sides of the middle connecting pipe and are oppositely arranged, the oil collecting pipeline penetrates through the sealing rubber rings in the fixed glands, two ends of the middle connecting pipe are respectively screwed in the connecting screw holes of the two fixed glands, and a sealing rubber gasket is arranged between the port of the middle connecting pipe and the port of the oil collecting pipeline; and pressure-resistant and corrosion-resistant chemical sealant is injected into the annular cavity of the sealant ring. The mechanical seal and the chemical seal are utilized to carry out effective sealing, and the construction is safe.