摘要：【中文】本发明涉及一种主动脉内双气囊驱动反搏导管装置，该主动脉内双气囊驱动反搏导管装置包括：导管(2)；沿所述导管(2)的纵向前后相继地分别环绕布置在所述导管上的第一气囊(4)和第二气囊(6)，其中，所述第一气囊(4)位于所述导管(2)的远端末端(5)，而所述第二气囊(6)的位置则紧邻所述第一气囊(4)近端；所述第一气囊(4)和所述第二气囊(6)周期性地膨胀至能够接近阻塞主动脉血流的尺寸和收缩至能够不妨碍血流通过的尺寸；其中，通过所述第一气囊(4)周期性地在心脏舒张期膨胀并在心脏收缩期抽瘪的泵送及抽吸功能，和所述第二气囊(6)相反地在心脏收缩期膨胀且在心脏舒张期抽瘪的阀门功能，一起辅助抽吸左心室血液单向向前驱动。 【EN】The invention relates to an intra-aortic double-balloon driven counterpulsation catheter device, which comprises: a conduit (2); -successively one after the other in the longitudinal direction of the catheter (2) surrounding a first balloon (4) and a second balloon (6) respectively arranged thereon, wherein the first balloon (4) is located at the distal tip (5) of the catheter (2) and the second balloon (6) is located immediately proximal to the first balloon (4); the first balloon (4) and the second balloon (6) are periodically inflated to a size that is capable of approaching occlusion of aortic blood flow and deflated to a size that is capable of not obstructing blood flow therethrough; wherein the pumping and pumping functions of the first balloon (4) which is periodically inflated in diastole and deflated in systole, and the valve function of the second balloon (6) which is oppositely inflated in systole and deflated in diastole, assist the pumping of left ventricular blood to drive forward in one direction.

摘要：【中文】本发明涉及一种带可压缩缝合缘的主动脉生物瓣膜，属于心血管外科领域的无源医疗器械领域。该瓣膜包括瓣膜支架和瓣叶，瓣膜支架包括流入端、中间段和流出端；流入端由可压缩基座环、包裹在基座环上的聚合物层及包裹在聚合物层外面的聚合物缝合缘组成，中间段由平直的支撑杆和向外凸起的弧形定位杆组成，支撑杆和定位杆的一端固定在可压缩基座环上，另一端与流出端连接；流出端为喇叭口形状的网格结构；瓣叶位于瓣膜支架的中间段内部，固定在支撑杆和基座环上，形成三个以上可活动开闭的部分。该瓣膜可用于植入到主动脉膜狭窄和主动脉关闭不全病变的原位主动脉瓣膜位置，具有应用范围广、定位准确、贴合紧密、综合损伤小、瓣膜耐久性长的特点。 【EN】The invention relates to an aortic biological valve with a compressible suture edge, and belongs to the field of passive medical instruments in the field of cardiovascular surgery. The valve comprises a valve stent and valve leaflets, the valve stent comprising an inflow end, a middle section and an outflow end; the inflow end consists of a compressible base ring, a polymer layer wrapped on the base ring and a polymer sewing edge wrapped outside the polymer layer, the middle section consists of a straight supporting rod and an arc-shaped positioning rod protruding outwards, one end of the supporting rod and one end of the positioning rod are fixed on the compressible base ring, and the other end of the supporting rod and the other end of the positioning rod are connected with the outflow end; the outflow end is of a grid structure in a bell mouth shape; the valve leaf is positioned in the middle section of the valve support and fixed on the support rod and the base ring to form more than three parts which can be movably opened and closed. The valve can be implanted into the position of an in-situ aortic valve with aortic stenosis and aortic incompetence, and has the characteristics of wide application range, accurate positioning, tight fitting, small comprehensive damage and long valve durability.

摘要：【中文】本发明涉及一种继发性三尖瓣反流的分级标准，是通过超声心动图提供一套可以综合评估三尖瓣反流的参数与方法，并以所述参数制定分级标准，结合反流程度及肺动脉收缩压，选择合理的三尖瓣成形手术：大部分I级患者可暂不处理，II级患者更多地给予线性成形技术，III‑IV级则更积极地使用成形环。本发明提供的分级标准通过利用瓣环直径指数和瓣叶闭合高度对继发性三尖瓣反流进行分级，并制定治疗策略，可以获得良好的手术效果，明显改善预后，避免患者术后再出现严重的三尖瓣反流，甚至右心衰竭的情况，有效降低了二次三尖瓣成形手术的可能性；具有重大临床意义，能够有效弥补目前临床判断不足的情况，作为可信的术前综合评估指标。 【EN】The invention relates to a grading standard of secondary tricuspid regurgitation, which provides a set of parameters and a method capable of comprehensively evaluating the tricuspid regurgitation through an echocardiogram, establishes the grading standard according to the parameters, combines the regurgitation degree and the pulmonary artery systolic pressure, and selects a reasonable tricuspid valvuloplasty operation: most patients of class I may remain untreated, class II patients are more amenable to linear shaping techniques, and class III-IV patients are more aggressive in using the shaping ring. According to the grading standard provided by the invention, the valve ring diameter index and the valve leaflet closing height are utilized to grade the secondary tricuspid valve regurgitation, and a treatment strategy is formulated, so that a good operation effect can be obtained, the prognosis is obviously improved, the serious tricuspid valve regurgitation and even the right heart failure of a patient are avoided after the operation, and the possibility of secondary tricuspid valve forming operation is effectively reduced; has great clinical significance, can effectively make up for the condition of insufficient clinical judgment at present, and can be used as a credible preoperative comprehensive evaluation index.

摘要：【中文】本发明公开提供了一种光纤式CO2、O2浓度快速采集探头，包括发光部，受光部以及光纤主体；发光部包括第一发光元件和第二发光元件；光纤主体为中空圆柱形，内侧设有玻璃态导光柱，外侧设有保护套，受光部设于玻璃态导光柱内侧中部；受光部包括椭圆形载体，氧气荧光敏感膜以及二氧化碳荧光敏感膜；氧气荧光敏感膜与氧化碳荧光敏感膜贴附于椭圆形载体的两面。本发明本发明能够实现实时超快反应的O2和CO2测定信号采样；并且可以直接将超快反应的O2和CO2测定光敏感信号转换成电信号，减少测定时间延迟误差；同时直接避免了传统CO2、O2分析装置需要微量泵所产生的采样时间延迟，实现CO2、O2测定的反应时间和精准度。 【EN】The invention discloses and provides an optical fiber type CO2 and O2 concentration rapid acquisition probe, which comprises a light emitting part, a light receiving part and an optical fiber main body, wherein the light emitting part is arranged on the light receiving part; the light emitting section includes a first light emitting element and a second light emitting element; the optical fiber main body is hollow cylindrical, the glass state light guide column is arranged on the inner side of the optical fiber main body, the protective sleeve is arranged on the outer side of the optical fiber main body, and the light receiving part is arranged in the middle of the inner side of the glass state light guide column; the light receiving part comprises an oval carrier, an oxygen fluorescent sensitive film and a carbon dioxide fluorescent sensitive film; the oxygen fluorescent sensitive film and the carbon oxide fluorescent sensitive film are attached to two sides of the oval carrier. The invention can realize the sampling of O2 and CO2 measuring signals of real-time ultrafast reaction; and the light sensitive signals measured by the ultra-fast reaction O2 and CO2 can be directly converted into electric signals, so that the measurement time delay error is reduced; meanwhile, sampling time delay caused by the need of a micro pump of the traditional CO2 and O2 analysis devices is directly avoided, and the reaction time and accuracy of CO2 and O2 measurement are realized.

摘要：【中文】本发明公开了LPA2及其激动剂的应用，涉及生物医学技术领域。本发明公开的LPA2(溶血磷脂酸受体2亚型)或其激动剂的用途，该用途选自如下至少一种：(1)用于制备治疗或预防缺血性疾病的药物；(2)用于制备治疗或预防具有血管渗漏症状的疾病的药物。本发明为治疗或预防缺血性疾病及其他血管渗漏引起的疾病，提供了一种新的药物和治疗思路。 【EN】The invention discloses an LPA2 and application of an agonist thereof, and relates to the technical field of biomedicine. The invention discloses an LPA2 (lysophosphatidic acid receptor subtype 2) or an agonist thereof, which is used for treating diabetes and is selected from at least one of the following: (1) for the preparation of a medicament for the treatment or prevention of ischemic diseases; (2) for the preparation of a medicament for the treatment or prevention of a disease with symptoms of vascular leakage. The invention provides a new medicine and a new treatment idea for treating or preventing ischemic diseases and diseases caused by other vascular leakage.

摘要：【中文】公开了一种瓣膜图像处理方法、瓣膜图像处理装置和电子设备。该瓣膜图像处理方法包括：获取先前帧的第一瓣膜灰度图和第一内腔图以及当前帧的第二瓣膜灰度图和第二内腔图；基于第一瓣膜灰度图获得先前帧的第一水平集函数图像；通过预测器从第一瓣膜灰度图、第一水平集函数图像、第一内腔图、第二瓣膜灰度图和第二内腔图获得当前帧的第二水平集函数图像和掩码图像；通过距离正则化水平集演化算法从第二瓣膜灰度图、第二水平集函数图像和掩码图像获得瓣膜区域轮廓图；以及，基于瓣膜区域轮廓图确定瓣膜信息。这样，能够获得瓣膜部分的准确信息。 【EN】Disclosed are a valve image processing method, a valve image processing device and an electronic apparatus. The valve image processing method comprises the following steps: acquiring a first valve gray-scale image and a first inner cavity image of a previous frame and a second valve gray-scale image and a second inner cavity image of a current frame; obtaining a first level set function image of a previous frame based on the first valvular grayscale map; obtaining a second level set function image and a mask image of the current frame from the first valve gray scale image, the first level set function image, the first lumen image, the second valve gray scale image and the second lumen image through a predictor; obtaining an valve region contour map from the second valve gray scale image, the second level set function image and the mask image through a distance regularization level set evolution algorithm; and determining valve information based on the valve region contour map. In this way, accurate information of the valve portion can be obtained.

摘要：【中文】本发明公开了人参皂苷Rb2(Ginsenoside Rb2)在制备预防和/或治疗动脉粥样硬化药物中的应用以及提供一种预防和/或治疗与血管细胞功能障碍相关的动脉粥样硬化的药物组合物。进一步，发明人还公开了一种microRNA‑216a(miR‑216a)抑制剂，以及其在动脉粥样硬化中的应用。本发明阐明了人参皂苷Rb2可通过靶向结合miR‑216a，延缓其介导的血管内皮细胞和巨噬细胞衰老，减轻巨噬细胞的脂质蓄积和炎症反应，证实人参皂苷Rb2对miR‑216a介导的血管细胞功能障碍有改善作用，可用于预防和/或治疗动脉粥样硬化的药物开发，为传统中草药治疗动脉粥样硬化疾病提供重要依据。 【EN】The invention discloses application of Ginsenoside Rb2(Ginsenoside Rb2) in preparing a medicament for preventing and/or treating atherosclerosis and provides a pharmaceutical composition for preventing and/or treating atherosclerosis related to vascular cell dysfunction. Further, the inventor also discloses a microRNA-216a (miR-216a) inhibitor and application thereof in atherosclerosis. The invention discloses that ginsenoside Rb2 can delay the aging of vascular endothelial cells and macrophages mediated by the ginsenoside Rb2 through targeted combination with miR-216a, and alleviate the lipid accumulation and inflammatory reaction of the macrophages, and proves that ginsenoside Rb2 has an improvement effect on miR-216a mediated vascular cell dysfunction, can be used for development of medicaments for preventing and/or treating atherosclerosis, and provides an important basis for treatment of atherosclerotic diseases by traditional Chinese herbal medicines.

摘要：【中文】本发明提供了肝素或阿司匹林在制备主动脉腔内修复的药物中的应用以及一种主动脉和冠状动脉疾病一站式腔内介入的手术方法。本发明具体提供了依次对病人实施主动脉腔内修复术和经皮冠状动脉介入治疗。本发明属于医学治疗领域，实施本发明具有以下优势：(1)两种疾病一站式处理，既避免了分次手术时抗血小板治疗上的矛盾，也避免了分次手术的潜在风险；(2)患者只经历一次麻醉和手术，心理更容易接受；(3)降低住院费用，缩短住院时长，降低医疗资源消耗。 【EN】The invention provides application of heparin or aspirin in preparing a medicine for aorta intracavity repair and a one-stop intracavity intervention operation method for aortic and coronary artery diseases. The invention particularly provides the sequential application of aortic endoluminal repair and percutaneous coronary intervention to a patient. The invention belongs to the field of medical treatment, and has the following advantages: (1) the two diseases are treated in a one-stop mode, so that the contradiction of antiplatelet treatment in the fractional operation is avoided, and the potential risk of the fractional operation is also avoided; (2) the patient only undergoes anesthesia and operation once, and the psychology is more acceptable; (3) reduce the hospitalization cost, shorten the hospitalization time and reduce the medical resource consumption.

摘要：【中文】本发明涉及医疗器械技术领域，具体公开了一种高效上针器，包括第一夹板及第二夹板，所述第一夹板和第二夹板均采用弹性金属材料制成；所述第一夹板的下端与第二夹板的下端以单自由度转动方式相连接，所述第一夹板的内侧面与第二夹板的内侧面相对设置且两内侧面之间形成用于夹持缝合针的夹持口。通过本发明，进行上针操作时可同时夹持两根缝合针，提高上针效率，从而利于治疗效率的提高。 【EN】The invention relates to the technical field of medical instruments, and particularly discloses a high-efficiency needle applying device which comprises a first clamping plate and a second clamping plate, wherein the first clamping plate and the second clamping plate are both made of elastic metal materials; the lower end of the first clamping plate is connected with the lower end of the second clamping plate in a single-degree-of-freedom rotation mode, the inner side face of the first clamping plate is opposite to the inner side face of the second clamping plate, and a clamping opening used for clamping a suture needle is formed between the two inner side faces. By the invention, two suture needles can be clamped simultaneously during needle feeding operation, and the needle feeding efficiency is improved, thereby being beneficial to improving the treatment efficiency.

摘要：【中文】本发明属于临床生物样本检测技术领域，具体涉及血浆中儿茶酚胺及其代谢物检测技术，特别涉及高通量液相色谱串联质谱法检测儿茶酚胺及其代谢物(肾上腺素、去甲肾上腺素、多巴胺、甲氧基肾上腺素、甲氧基去甲肾上腺素、3‑甲氧基酪胺)的方法。所述方法包括：标准溶液配制、样本处理、样本检测以及计算公式。该方法可以同时检测儿茶酚胺及其代谢物共6种物质，具有高准确度、高灵敏度、高特异性以及所需样本体积少、样本前处理简单及耐受性好等优点。 【EN】The invention belongs to the technical field of clinical biological sample detection, particularly relates to a technique for detecting catecholamine and metabolites thereof in blood plasma, and particularly relates to a method for detecting catecholamine and metabolites thereof (adrenaline, noradrenaline, dopamine, methoxyadrenaline, methoxynoradrenaline and 3-methoxytyramine) by a high-throughput liquid chromatography tandem mass spectrometry method. The method comprises the following steps: preparing standard solution, processing samples, detecting samples and calculating formulas. The method can be used for simultaneously detecting 6 substances including catecholamine and metabolites thereof, and has the advantages of high accuracy, high sensitivity, high specificity, small required sample volume, simple sample pretreatment, good tolerance and the like.