摘要：一种水凝胶及其制备方法，水凝胶包括：天然高分子化合物、磷脂、交联剂。本发明选用的磷脂分子可降低材料的摩擦系数，减轻关节磨损。

摘要：【中文】本发明提供了一种石墨烯透皮给药微针，所述微针的基材为药剂学使用的具有生物相容性的有机高分子聚合物，所述有机高分子聚合物内均匀分散有石墨烯材料，所述有机高分子聚合物选自聚乙烯吡咯烷酮、聚乙烯醇、透明质酸、聚乳酸‑羟基乙酸共聚物、羧甲基纤维素中的一种，所述石墨烯材料为石墨烯或者经化学、物理方法处理的石墨烯中的一种。本发明的石墨烯透皮给药微针具有很好的机械性能，使微针容易穿透角质层；本发明的石墨烯透皮给药微针具有很好的控制药物释放的能力，且可通过红外光的方式控制药物释放；本发明的石墨烯透皮给药微针具有较为优异的抗菌性能，使微针易于保存；本发明的石墨烯透皮给药微针的制备方法简单，成本低。 【EN】The invention provides a graphene transdermal drug delivery microneedle, wherein a base material of the microneedle is a pharmaceutically used biocompatible organic high molecular polymer, a graphene material is uniformly dispersed in the organic high molecular polymer, the organic high molecular polymer is one selected from polyvinylpyrrolidone, polyvinyl alcohol, hyaluronic acid, polylactic acid-glycolic acid copolymer and carboxymethyl cellulose, and the graphene material is one selected from graphene or graphene treated by a chemical method and a physical method. The graphene transdermal drug delivery microneedle has good mechanical properties, so that the microneedle can easily penetrate through the stratum corneum; the graphene transdermal drug delivery microneedle has good capability of controlling drug release, and can control the drug release in an infrared light mode; the graphene transdermal drug delivery microneedle has excellent antibacterial performance, so that the microneedle is easy to store; the preparation method of the graphene transdermal drug delivery microneedle is simple and low in cost.

摘要：本发明的实施例公开了一种微针贴片及其制备方法。本发明实施例的微针贴片的制备方法例如包括：将高分子材料溶于水中得到高分子聚合物水溶液；在所述高分子聚合物水溶液中加入多柔比星和硫化铜纳米颗粒得到微针基质溶液；将所述微针基质溶液置入微针阴模中并进行离心、固化，得到微针基质层；以及将基底层贴附至微针基质层上得到所述微针贴片。本发明实施例的微针贴片可更好地治疗乳腺癌。

摘要：本发明涉及分析仪器和药物分析技术领域，具体公开了一种芯片式活体固相微萃取装置系统及其用于纳米药物药动学精准分析的方法，芯片式活体固相微萃取装置系统包括芯片入口端和芯片出口端，所述芯片入口端和芯片出口端打孔，所述芯片入口端和芯片出口端通过导管连通形成微通道，所述芯片入口端填充有固相微萃取填料，所述芯片出口端设有阻挡固相微萃取填料的栅栏结构。本发明的系统可以应用纳米药物游离浓度的活体实时分析；本发明方法操作步骤简单，检测时间短，时间分辨率为1.5min，能够完全实现在线分析、实时监测纳米药物及其代谢物血药浓度的变化。

摘要：【中文】本发明提供了一种抗菌复合聚乙烯醇纤维的制备方法，包括以下步骤：(1)将茶多酚和硝酸银溶液混合得到混合溶液A，硝酸银的质量浓度为0.5％～3％，茶多酚的质量浓度为2.5％～4.0％；(2)将聚乙烯醇溶解在混合溶液A中，并在80～100℃下搅拌3～5小时，所述聚乙烯醇与所述混合溶液A的重量比为5～15:100；(3)加入石墨烯分散均匀后静置；(4)将步骤(3)得到的混合液进行纺丝后在紫外光下照射，得到抗菌复合聚乙烯醇纤维。本发明的方法将聚乙烯醇、茶多酚、硝酸银和氯化锂混合溶液在80～100℃下搅拌3～5小时后添加石墨烯静置后纺丝，并且通过在紫外光下照射，提高了抗菌复合聚乙烯醇纤维的抗菌性能，利用抗菌复合聚乙烯醇纤维制备得到的无纺布的抗菌性能更好。 【EN】The invention provides a preparation method of an antibacterial composite polyvinyl alcohol fiber, which comprises the following steps: (1) mixing tea polyphenol with silver nitrate solution to obtain mixed solution A, wherein the mass concentration of silver nitrate is 0.5-3%, and the mass concentration of tea polyphenol is 2.5-4.0%; (2) dissolving polyvinyl alcohol in the mixed solution A, and stirring for 3-5 hours at 80-100 ℃, wherein the weight ratio of the polyvinyl alcohol to the mixed solution A is 5-15: 100; (3) adding graphene, dispersing uniformly, and standing; (4) and (4) spinning the mixed solution obtained in the step (3), and then irradiating under ultraviolet light to obtain the antibacterial composite polyvinyl alcohol fiber. According to the method, the mixed solution of polyvinyl alcohol, tea polyphenol, silver nitrate and lithium chloride is stirred for 3-5 hours at 80-100 ℃, graphene is added for standing and spinning, the antibacterial performance of the antibacterial composite polyvinyl alcohol fiber is improved by irradiation of ultraviolet light, and the non-woven fabric prepared from the antibacterial composite polyvinyl alcohol fiber has better antibacterial performance.