摘要：【中文】本发明公开了重组人偏肺病毒及其制备方法和应用。本发明首先公开了重组病毒，该重组病毒的冷适应、减毒流感病毒的NS基因、靶标流感病毒的HA基因和靶标流感病毒的NA基因中任一种基因被替换。本发明进一步公开了上述重组病毒在制备预防和/或治疗流感病毒和/或人偏肺病毒引起的疾病的产品中的应用。本发明从基因水平对HMPV抗原表位和流感病毒基因组进行操作，制备冷适应流感病毒为载体的重组HMPV疫苗株，解决了HMPV疫苗免疫引发的免疫损伤难题，将是呼吸道传染性疾病疫苗领域的新里程碑。另外，本发明提供的HMPV嵌合疫苗保护更多人群免受流感病毒和HMPV之害，为实现“一苗两用”或“一苗多用”目的奠定了基础。 【EN】The invention discloses a recombinant human metapneumovirus and a preparation method and application thereof. The present invention first discloses a recombinant virus in which any one of the NS gene of cold-adapted attenuated influenza virus, the HA gene of target influenza virus and the NA gene of target influenza virus is replaced. The invention further discloses application of the recombinant virus in preparing products for preventing and/or treating diseases caused by influenza viruses and/or human metapneumoviruses. The invention operates HMPV epitope and influenza virus genome from gene level to prepare the recombinant HMPV vaccine strain taking cold-adapted influenza virus as a carrier, solves the problem of immune damage caused by HMPV vaccine immunity, and is a new milestone in the field of respiratory infectious disease vaccines. In addition, the HMPV chimeric vaccine provided by the invention protects more people from influenza virus and HMPV, and lays a foundation for realizing the purposes of one-vaccine dual-purpose or one-vaccine multi-purpose.

摘要：【中文】本发明公开了一种与装药瓶配合使用的无针注射器，设置了包括外套管和推送药物的柱塞，所述外套管左端底部设有喷射孔，还包括三通管和设有外螺纹的套筒，所述三通管右端口设有与装药瓶的瓶口相配合的内螺纹，三通管左端内部设有封堵右端口的阀芯，在三通管中部的顶面壁上设有排气孔；所述外套管左端底部的外周壁上设有与外套管内腔相连通的进药孔，在所述进药孔上同心焊接套筒，三通管的下端口通过螺纹与套筒连接。其有益技术效果是：结构简单容易操作，装药方便排气顺畅，可以反复使用，保护环境，具有提高医护操作效率的特点。 【EN】The invention discloses a needleless injector used in cooperation with a medicine containing bottle, which is provided with an outer sleeve and a plunger for pushing medicine, wherein the bottom of the left end of the outer sleeve is provided with a jet hole; the outer peripheral wall of the bottom of the left end of the outer sleeve is provided with a medicine inlet hole communicated with the inner cavity of the outer sleeve, the medicine inlet hole is concentrically welded with a sleeve, and the lower port of the three-way pipe is connected with the sleeve through threads. The beneficial technical effects are as follows: simple structure easy to operate, the powder charge is convenient to exhaust smoothly, can use repeatedly, and the environmental protection has the characteristics that improve the operating efficiency of doctorsing and nurses.

摘要：【中文】本发明公开了一种无针注射装置，设置了包括充装注射用药的药瓶，所述药瓶设有活塞盖、密封帽和保护套；在药瓶左端底部设有带喷射孔的喷射头，所述活塞盖滑动置于药瓶内，活塞盖中心设有带外部密封盖的装药孔，所述密封帽套装在药瓶右端部并将活塞盖密封，所述保护套装在喷射头上。这种药瓶的活塞盖在装药时作为瓶盖使用，在注射时作为活塞使用，其有益技术效果是：该装置将药瓶置于注射器内直接注射，节省了注射之前灌装药物的时间，避免了药物和注射器被污染，具有结构简单操作方便，提高医护操作效率，减轻环境污染的特点。 【EN】The invention discloses a needleless injection device, which is provided with a medicine bottle for filling injection medicine, wherein the medicine bottle is provided with a piston cover, a sealing cap and a protective sleeve; the medicine bottle is characterized in that the bottom of the left end of the medicine bottle is provided with an injector head with an injection hole, the piston cover is arranged in the medicine bottle in a sliding mode, the center of the piston cover is provided with a medicine loading hole with an external sealing cover, the sealing cap is sleeved on the right end of the medicine bottle and seals the piston cover, and the protection cap is sleeved on the injector head. The piston cover of the medicine bottle is used as a bottle cover during medicine charging and used as a piston during injection, and has the beneficial technical effects that: the device arranges the medicine bottle in the injector for direct injection, saves the time for filling the medicine before injection, avoids the medicine and the injector from being polluted, and has the characteristics of simple structure, convenient operation, improvement of medical care operation efficiency and reduction of environmental pollution.