摘要：【中文】本发明属于医药及保健品领域，具体涉及苦蘵中睡茄内酯提取物在制备防治非酒精性脂肪肝病药物或保健品中应用。在MCD饮食诱导的NASH模型中，睡茄内酯提取物能够抑制肝脏脂肪变性，降低血浆中ALT、和/或AST，以及肝组织中的TG、和/或TC，对NASH的发生发展具有一定的预防和治疗作用。在化学诱导剂所致肝损伤动物模型中，睡茄内酯提取物具有良好的肝损伤保护作用和抗肝纤维化活性。本发明所述睡茄内酯提取物，具有效果突出，安全性较高，有望发展成为治疗和预防非酒精性脂肪性肝病，以及肝损伤保护、抗肝纤维化的有效药物。 【EN】The invention belongs to the field of medicines and health-care products, and particularly relates to application of a withanolide extract in physalis angulata in preparation of a medicine or health-care product for preventing and treating non-alcoholic fatty liver disease. In the MCD diet-induced NASH model, the withanolide extract can inhibit liver steatosis, reduce ALT and/or AST in plasma and TG and/or TC in liver tissues, and has certain prevention and treatment effects on the occurrence and development of NASH. In an animal model of liver injury caused by a chemical inducer, the withanolide extract has good liver injury protection effect and anti-hepatic fibrosis activity. The withanolide extract has the advantages of outstanding effect and high safety, and is expected to be developed into an effective medicament for treating and preventing non-alcoholic fatty liver disease, protecting liver injury and resisting hepatic fibrosis.

摘要：【中文】本发明属于医药及保健品领域，具体涉及睡茄内酯化合物Physalin B在制备预防与治疗非酒精性脂肪肝病药物或保健品中应用。在MCD饮食诱导的NASH模型中，Physalin B能够抑制肝脏脂肪变性，降低血浆中ALT、和/或AST，以及肝组织中的TG、和/或TC，对NASH的发生发展具有一定的预防和治疗作用。在化学诱导剂所致肝损伤动物模型中，Physalin B具有良好的肝损伤保护作用和抗肝纤维化活性。本发明所述睡茄内酯化合物Physalin B，具有效果突出，安全性较高，有望发展成为治疗和预防非酒精性脂肪性肝病，以及肝损伤保护、抗肝纤维化的有效药物。 【EN】The invention belongs to the field of medicines and health-care products, and particularly relates to application of a withanolide compound Physalin B in preparation of a medicine or a health-care product for preventing and treating non-alcoholic fatty liver disease. In the MCD diet-induced NASH model, Phylysin B can inhibit liver steatosis, reduce ALT and/or AST in plasma and TG and/or TC in liver tissues, and has certain prevention and treatment effects on the occurrence and development of NASH. In an animal model of liver injury caused by a chemical inducer, physiolin B has good liver injury protection effect and anti-hepatic fibrosis activity. The withanolide compound Physalin B has the advantages of outstanding effect and higher safety, and is expected to be developed into an effective medicament for treating and preventing non-alcoholic fatty liver disease, protecting liver injury and resisting hepatic fibrosis.