摘要：【中文】本发明考虑尺度效应的聚合物血管支架力学性能预测方法属于介入性医疗器械技术领域，涉及一种考虑尺度效应的聚合物血管支架力学性能预测方法。该方法基于Cosserat连续介质理论，通过引入偶应力和曲率应变，得到广义应力和广义应变，建立考虑尺度效应的聚合物材料弹性本构关系。采用有限元法构建带有微空洞的聚合物材料体胞模型，获取了考虑微空洞尺度效应的聚合物材料等效本构关系函数。经过有限元分析计算，最终实现对聚合物血管支架力学性能的预测。本发明考虑微空洞尺度效应的聚合物材料等效本构关系函数，采用了一种新的计算方法，揭示了材料降解过程中聚合物血管支架力学性能的变化规律，能够实现聚合物血管支架力学性能的精准预测。 【EN】The invention discloses a method for predicting mechanical properties of a polymer intravascular stent by considering a scale effect, belongs to the technical field of interventional medical instruments, and relates to a method for predicting mechanical properties of a polymer intravascular stent by considering the scale effect. The method is based on the Cosserat continuous medium theory, obtains generalized stress and generalized strain by introducing even stress and curvature strain, and establishes the elastic constitutive relation of the polymer material considering the scale effect. A polymer material cell model with micro-cavities is constructed by adopting a finite element method, and a polymer material equivalent constitutive relation function considering the micro-cavity scale effect is obtained. And finally realizing the prediction of the mechanical property of the polymer intravascular stent through finite element analysis and calculation. The invention discloses a change rule of the mechanical property of a polymer vascular stent in the material degradation process by taking the equivalent constitutive relation function of the polymer material with the micro-cavity scale effect into consideration and adopting a new calculation method, and can realize accurate prediction of the mechanical property of the polymer vascular stent.

摘要：【中文】本发明考虑尺度效应的聚合物血管支架结构优化设计方法属于介入性医疗器械领域，涉及了一种考虑尺度效应的聚合物血管支架结构优化设计方法。该方法在考虑尺度效应对支架力学行为影响的基础上，通过定义优化问题，采用优化拉丁超立方法获取初始样本点，结合有限元法，利用Kriging代理模型建立目标函数与设计变量间的近似函数关系。基于近似函数和改善期望加点准则，联合遗传算法与序列二次规划算法进行并行运算得到支架结构的改进设计。当目标函数最优解满足收敛条件时，输出支架最终的优化设计结果。本发明弥补了现有技术忽略尺度效应的不足，并将新型本构关系引入到有限元计算中，采用优化算法提高了计算精度和计算效率，适用性强。 【EN】The invention relates to a scale effect-considered polymer intravascular stent structure optimization design method, belongs to the field of interventional medical instruments, and relates to a scale effect-considered polymer intravascular stent structure optimization design method. The method comprises the steps of obtaining initial sample points by defining an optimization problem and adopting an optimized Latin hypercube method on the basis of considering the influence of a scale effect on the mechanical behavior of a support, and establishing an approximate function relation between a target function and a design variable by using a Kriging agent model in combination with a finite element method. And based on the approximate function and the criterion of improving the expected point adding, combining the genetic algorithm and the sequence quadratic programming algorithm to carry out parallel operation to obtain the improved design of the bracket structure. And outputting the final optimization design result of the support when the optimal solution of the objective function meets the convergence condition. The invention makes up the defect of neglecting the scale effect in the prior art, introduces the novel constitutive relation into the finite element calculation, adopts the optimization algorithm to improve the calculation precision and the calculation efficiency, and has strong applicability.