摘要：【中文】本发明提供了一种异丙托溴铵晶体的制备方法。具体步骤为：将异丙托溴铵加入到良性溶剂中后，加热搅拌溶解，溶液澄清后，滴加不良溶剂，通过程序降温析晶得到高纯度的异丙托溴铵晶体。本发明所述的制备方法操作简单、产品收率高、纯度高，并且该晶体具有较好的溶解性与化学稳定性，适合于工业化生产。 【EN】The invention provides a preparation method of ipratropium bromide crystals. The method comprises the following specific steps: adding ipratropium bromide into a benign solvent, heating, stirring and dissolving, after the solution is clarified, dropwise adding a poor solvent, and performing temperature reduction and crystallization by a program to obtain a high-purity ipratropium bromide crystal. The preparation method provided by the invention is simple to operate, high in product yield and high in purity, and the crystal has good solubility and chemical stability and is suitable for industrial production.

摘要：【中文】本发明涉及药物技术领域，具体涉及一种达沙替尼晶型及制备方法。本发明的达沙替尼晶型物的粉末衍射图谱中2θ在5.8±0.2°，7.2±0.2°，14.4±0.2°，16.0±0.2°处有衍射峰。X‑射线单晶衍射图谱显示本发明制备的晶型为达沙替尼乙醇溶剂合物晶，型纯度高，稳定性好，溶解度优良，尤其在溶出实验中展现出了优良的溶出性能，其制备过程易于工业化，具有广阔的应用前景。 【EN】The invention relates to the technical field of medicines, and particularly relates to a dasatinib crystal form and a preparation method thereof. In the powder diffraction pattern of the dasatinib crystal form substance, diffraction peaks exist at positions of 5.8 +/-0.2 degrees, 7.2 +/-0.2 degrees, 14.4 +/-0.2 degrees and 16.0 +/-0.2 degrees of 2 theta. The X-ray single crystal diffraction pattern shows that the crystal form prepared by the invention is dasatinib ethanol solvate crystal, the crystal form purity is high, the stability is good, the solubility is excellent, the excellent dissolution performance is particularly shown in a dissolution experiment, the preparation process is easy to industrialize, and the application prospect is wide.

摘要：【中文】本发明涉及药物技术领域，具体涉及技术领域一种达沙替尼新晶型及制备方法。本发明的达沙替尼新晶型的粉末衍射图谱中2θ在5.8±0.2°，6.9±0.2°，12.5±0.2°，13.2±0.2°，13.7±0.2°处有衍射峰。通过本发明制备的达沙替尼新晶型纯度高，稳定性好，溶解度优良，尤其在溶出实验中展现出了优良的溶出性能，其制备过程易于工业化，具有广阔的应用前景。 【EN】The invention relates to the technical field of medicines, in particular to a novel dasatinib crystal form and a preparation method thereof. In the powder diffraction pattern of the novel dasatinib crystal form, diffraction peaks exist at positions of 5.8 +/-0.2 degrees, 6.9 +/-0.2 degrees, 12.5 +/-0.2 degrees, 13.2 +/-0.2 degrees and 13.7 +/-0.2 degrees. The novel dasatinib crystal form prepared by the method has high purity, good stability and excellent solubility, particularly shows excellent dissolution performance in a dissolution experiment, is easy to industrialize in the preparation process, and has wide application prospect.

摘要：【中文】本发明属于化学药物制备技术领域，具体公开了伊布替尼晶型A单晶及其制备方法，将伊布替尼晶型A溶于良溶剂中，完全溶解后加入不良溶剂过滤析晶即得。经过本发明的技术方案可以培养出更多形状良好的伊布替尼晶型A单晶，工艺简单，单晶培养时间短，晶型稳定，易于挑选，在室温下挑选不易融化。 【EN】The invention belongs to the technical field of chemical drug preparation, and particularly discloses an ibrutinib crystal form A single crystal and a preparation method thereof. The technical scheme of the invention can be used for culturing more ibrutinib crystal form A single crystals with good shapes, and has the advantages of simple process, short single crystal culture time, stable crystal form, easy selection and difficult melting in selection at room temperature.

摘要：【中文】本发明提供了一种阿昔替尼晶型，涉及晶型药物分子技术领域。该阿昔替尼晶型使用Cu‑Kα辐射，以2θ表示的X射线衍射谱图在9.53±0.2°，14.69±0.2°，17.67±0.2°，19.11±0.2°，19.50±0.2°，20.83±0.2°，23.01±0.2°，24.40±0.2°，25.72±0.2°，28.51±0.2°，28.89±0.2°，30.70±0.2°有特征峰；晶体学测量参数是：单斜晶系，空间群为P2₁/c；晶胞参数为：α＝90.00°，β＝109.486(3)°，γ＝90.00°，晶胞体积并提供了相关制备方法和应用。本发明的阿昔替尼晶型稳定性好、光照不敏感、溶解度较好，利用其制备药物便于储存，同时可增加生物利用度，提高药效。 【EN】The invention provides an axitinib crystal form, which relates to the technical field of crystal form drug molecules and is radiated by Cu-K α, wherein an X-ray diffraction spectrogram expressed by 2 theta has characteristic peaks at 9.53 +/-0.2 degrees, 14.69 +/-0.2 degrees, 17.67 +/-0.2 degrees, 19.11 +/-0.2 degrees, 19.50 +/-0.2 degrees, 20.83 +/-0.2 degrees, 23.01 +/-0.2 degrees, 24.40 +/-0.2 degrees, 25.72 +/-0.2 degrees, 28.51 +/-0.2 degrees, 28.89 +/-0.2 degrees and 30.70 +/-0.2 degrees, and the crystallography measurement parameter is a monoclinic system, the space group is P2 degrees₁C; the unit cell parameters are:α ═ 90.00 °, β ═ 109.486(3 °), γ ═ 90.00 °, unit cell volumeAnd provideRelated preparation method and application are provided. The axitinib crystal form has good stability, insensitivity to illumination and good solubility, and the medicament prepared by the axitinib crystal form is convenient to store, and can increase the bioavailability and improve the medicament effect.