摘要：【中文】本发明涉及已知化合物的新合成方法技术领域，具体公开了一种舒更葡糖钠杂质的合成方法，本方法以摩尔比为1：（3.5‑4.5）：（7.5‑8.5）的八‑(6‑溴‑6‑脱氧)‑γ‑环糊精、3‑巯基丙酸与碱在40‑50℃反应14‑20h，再经过浆洗、重结晶等精制处理，得到舒更葡糖钠杂质。本方法所制得的舒更葡糖钠杂质纯度达99％以上，可作为对照品用于质量研究。 【EN】The invention relates to the technical field of new synthesis methods of known compounds, and particularly discloses a synthesis method of sugammadex sodium impurity, which comprises the following steps of: (3.5-4.5): (7.5-8.5) reacting octa- (6-bromo-6-deoxy) -gamma-cyclodextrin and 3-mercaptopropionic acid with alkali at 40-50 ℃ for 14-20h, and refining by pulp washing, recrystallization and the like to obtain the impurity of sugammadex sodium. The impurity purity of the sugammadex sodium prepared by the method reaches more than 99 percent, and the sugammadex sodium can be used as a reference substance for quality research.