摘要：【中文】本发明涉及一种美托洛尔缓释组合物及其制备方法，属于药物制剂领域。所述组合物，含有美托洛尔或其药学上可接受的盐和控释材料，任选地含有润滑剂和/或增塑剂。所述组合物可以采用热熔挤出制备。所述组合物易于制备，制备方法，简便易行，工序少，时间短，成本低，适于工业化生产。 【EN】The invention relates to a metoprolol sustained-release composition and a preparation method thereof, belonging to the field of pharmaceutical preparations. The composition comprises metoprolol or pharmaceutically acceptable salt thereof and a controlled release material, and optionally comprises a lubricant and/or a plasticizer. The composition may be prepared by hot melt extrusion. The composition is easy to prepare, the preparation method is simple and easy to implement, the working procedures are few, the time is short, the cost is low, and the composition is suitable for industrial production.

摘要：【中文】本发明涉及一种美托洛尔缓释片剂组合物及其制备方法，属于药物制剂领域。所述组合物，含有缓释微丸，稀释剂和润滑剂，任选含有包衣材料；其中，缓释微丸包含上药微丸和缓释层，上药微丸包含空白丸芯和活性成分。所述方法采用固含量高的混合液对空白丸芯进行包衣制备上药微丸，采用热熔包衣技术制备缓释微丸，工艺快速，流畅，相对时间短，既降低生产成本又能够保证产品质量。 【EN】The invention relates to a metoprolol sustained-release tablet composition and a preparation method thereof, belonging to the field of pharmaceutical preparations. The composition comprises sustained-release pellets, a diluent and a lubricant, and optionally comprises a coating material; the sustained-release pellet comprises a drug-loading pellet and a sustained-release layer, wherein the drug-loading pellet comprises a blank pellet core and an active ingredient. The method adopts the mixed solution with high solid content to coat the blank pellet core to prepare the drug-loading pellet, adopts the hot-melt coating technology to prepare the slow-release pellet, has quick and smooth process and short relative time, reduces the production cost and ensures the product quality.