摘要：【中文】提供了抑制TIGIT介导的信号传导的抗TIGIT抗体及其抗原结合片段，以及包含所述抗体或其抗原结合片段的组合及它们的使用方法。 【EN】anti-TIGIT antibodies and antigen-binding fragments thereof that inhibit TIGIT-mediated signaling are provided, as well as combinations comprising the antibodies or antigen-binding fragments thereof and methods of their use.