摘要：【中文】本发明涉及一种式(I)或(II)的化合物或其医药学上可接受的盐、溶剂合物、水合物、包含式(I)或(II)的化合物的医药组合物及其用途，其中各种马库什组如本文所描述。 【EN】The present invention relates to compounds of formula (I) or (II) or pharmaceutically acceptable salts, solvates, hydrates, pharmaceutical compositions comprising compounds of formula (I) or (II), and uses thereof, wherein the various markush groups are as described herein.

摘要：【中文】本发明提供式(I)化合物或其亚属结构或物质，或其医药学上可接受的盐、酯、溶剂合物及/或前药，及用于治疗或改善诸如癌症的异常细胞增生性病症的的方法及组合物，其中A、R²、R³、R¹⁰、E¹、E²、E³、Y及Z如本文中所定义。 【EN】The present invention provides compounds of formula (I) or subgeneric structures or materials thereof, or pharmaceutically acceptable salts, esters, solvates, and/or prodrugs thereof, and methods and compositions for treating or ameliorating an aberrant cell proliferative disorder, such as cancer, wherein A, R²、R³、R¹⁰、E¹、E²、E³Y and Z are as defined herein.