摘要：【中文】本发明涉及气雾剂领域，具体公开了一种呋塞米气雾剂，可用于急性心力衰竭发作时的快速给药。本发明中的呋塞米气雾剂成分如下：呋塞米、水、乙醇、丙二醇、辅酶Q及抛射剂为四氟乙烷、七氟丙烷。本发明制备的气雾剂具有良好的喷射效果及放置稳定性，每喷药物含量稳定，60％以上的液滴尺寸可达到1‑5μm，心肺吸收效果更好。同时，本发明中气雾剂的制备方法简单，放大生产难度低，具有重要的经济意义。 【EN】The invention relates to the field of aerosols, and particularly discloses a furosemide aerosol which can be used for rapid administration during acute heart failure attack. The furosemide aerosol comprises the following components: the furosemide, water, ethanol, propylene glycol, coenzyme Q and propellant are tetrafluoroethane and heptafluoropropane. The aerosol prepared by the invention has good spraying effect and placement stability, the content of each sprayed medicine is stable, more than 60 percent of liquid drops can reach 1-5 mu m, and the cardiopulmonary absorption effect is better. Meanwhile, the preparation method of the aerosol is simple, the amplification production difficulty is low, and the preparation method has important economic significance.

摘要：【中文】本发明公开了一种调压变压器，包括变压器铁心，所述变压器铁心上由内向外依次设有上下排列的低压绕组L1和低压绕组L2、上下排列的高压绕组H1和高压绕组H2以及上下排列的调压绕组T1和调压绕组T2，所述低压绕组L1首、尾端和低压绕组L2的首、尾端以及高压绕组H1的首尾端和高压绕组H2的首尾端可通过开关联结，并可通过该开关调节低压绕组L1首、尾端和低压绕组L2的首、尾端以及高压绕组H1的首尾端和高压绕组H2的首尾端的联结关系，完成高、低压绕组串或并联。本发明可实现在低压电压不变的前提下，改变高压额定电压，并增大调压范围的目的。 【EN】The invention discloses a voltage regulating transformer which comprises a transformer iron core, wherein a low-voltage winding L1 and a low-voltage winding L2 which are arranged up and down, a high-voltage winding H1 and a high-voltage winding H2 which are arranged up and down, and a voltage regulating winding T1 and a voltage regulating winding T2 which are arranged up and down are sequentially arranged on the transformer iron core from inside to outside, the head and the tail ends of the low-voltage winding L1 and the head and the tail ends of the low-voltage winding L2 as well as the head and the tail ends of the high-voltage winding H1 and the head and the tail ends of the high-voltage winding H2 can be connected through a switch, and the connection relationship between the head and the tail ends of the low-voltage winding L1 and the head and the tail ends of the low-voltage winding L2 as well as between the head and the. The invention can realize the purposes of changing the high-voltage rated voltage and enlarging the voltage regulation range on the premise of keeping the low-voltage unchanged.

摘要：【中文】本发明一种L‑半胱氨酸的基因工程菌及构建方法，以及该基因工程菌在微生物发酵制备L‑半胱氨酸中的应用。本发明通过(1)强化大肠杆菌L‑半胱氨酸合成途径的丝氨酸模块，增强大肠杆菌对丝氨酸的利用能力，(2)减弱丝氨酸的转运，减弱副产物对L‑半胱氨酸合成的影响，(3)增加硫模块合成基因的表达(4)质粒上异源表达Corynebacterium glutamicum的serC基因，得到L‑半胱氨酸高产的大肠杆菌基因工程菌株，L‑半胱氨酸产量从2.7g/L提高到3.83g/L。 【EN】The invention relates to a gene engineering bacterium of L-cysteine, a construction method and application of the gene engineering bacterium in preparing L-cysteine by microbial fermentation. According to the invention, the serine utilization capacity of escherichia coli to serine is enhanced by (1) strengthening a serine module of an escherichia coli L-cysteine synthesis way, (2) weakening the transfer of serine and weakening the influence of byproducts on L-cysteine synthesis, (3) increasing the expression of a sulfur module synthetic gene, (4) heterologously expressing the serC gene of Corynebacterium glutamicum on a plasmid, and obtaining the escherichia coli genetic engineering strain with high L-cysteine yield, wherein the L-cysteine yield is increased from 2.7g/L to 3.83 g/L.

摘要：【中文】本发明提供一种基于随机策略与多目标优化算法的施工场地平面布置方法，以待布置设施对应的矩形的左上顶点的位置坐标为决策变量，进行随机策略布置，并对随机生成的布置方案进行防重叠约束，形成多目标优化算法的初始种群；以实数编码的形式将随机生成的设施的布置位置坐标作为染色体基因座上的基因参与多目标优化算法的迭代运算，并在交叉、变异操作上进行自适应算法改进，最终得到最优的施工场地布置方案。本发明的有益效果：解决了现有施工场地布置策略存在的易丢解和局部最优解弊端，充分发挥了智能算法的全局寻优特点；从多个工程实际需求出发，最终的场地布置方案不再单一满足某一方面的需求，从整体上提高了场地布置方案的各项功能需求。 【EN】The invention provides a construction site plane arrangement method based on a random strategy and a multi-objective optimization algorithm, which comprises the steps of carrying out random strategy arrangement by taking the position coordinates of the upper left vertex of a rectangle corresponding to facilities to be arranged as a decision variable, and carrying out anti-overlapping constraint on a randomly generated arrangement scheme to form an initial population of the multi-objective optimization algorithm; and taking the randomly generated arrangement position coordinates of the facilities as genes on the chromosome gene loci in a real number coding mode to participate in iterative operation of a multi-objective optimization algorithm, and performing adaptive algorithm improvement on intersection and variation operations to finally obtain an optimal construction site arrangement scheme. The invention has the beneficial effects that: the defects of easy solution loss and local optimal solution existing in the conventional construction site arrangement strategy are overcome, and the global optimization characteristic of an intelligent algorithm is fully exerted; starting from a plurality of actual engineering requirements, the final site layout scheme does not singly meet the requirements of a certain aspect any more, and all functional requirements of the site layout scheme are improved on the whole.

摘要：【中文】本发明涉及一种适用于静脉溶栓禁忌症的局部溶栓取栓装置及其使用方法。包括主导管，主导管的两端分别为前端和后端，后端设置若干接口，前端封闭；主导管设置溶栓段，溶栓段的两端各设置若干球囊，溶栓段设置若干溶栓通道开口，若干球囊分别通过球囊管腔与一个接口连通；主导管的溶栓段与后端之间设置小循环管腔入口，溶栓段与前端之间设置小循环管腔出口；小循环管腔入口和小循环管腔出口通过主导管内部的血流管腔连通；若干溶栓通道开口分别与一个接口通过主导管内部的溶栓管腔连通。通过建立局部溶栓循环，把血栓逐步溶解带走，避免血栓碎片化和脱落流向下游毛细血管造成次生性组织损伤甚至死亡。 【EN】The invention relates to a local thrombolysis thrombus extraction device suitable for venous thrombolysis contraindication and a use method thereof. The device comprises a main duct, wherein the two ends of the main duct are respectively a front end and a rear end, the rear end is provided with a plurality of interfaces, and the front end is closed; the main catheter is provided with a thrombolysis section, two ends of the thrombolysis section are respectively provided with a plurality of balloons, the thrombolysis section is provided with a plurality of thrombolysis channel openings, and the balloons are respectively communicated with one interface through balloon lumens; a small circulation tube cavity inlet is arranged between the thrombolysis section and the rear end of the main catheter, and a small circulation tube cavity outlet is arranged between the thrombolysis section and the front end; the inlet of the small circulation lumen is communicated with the outlet of the small circulation lumen through a blood flow lumen inside the main catheter; the openings of the plurality of thrombolysis channels are respectively communicated with one interface through a thrombolysis tube cavity in the main tube. By establishing local thrombolysis circulation, thrombus is gradually dissolved and taken away, and secondary tissue damage and even death caused by thrombus fragmentation and falling to flow to downstream capillary vessels are avoided.

摘要：【中文】本发明公开了一种多绕组分裂变压器，包括变压器铁心，所述变压器铁心上由内向外依次设置有低压分裂绕组d1、调压绕组T、高压绕组G、低压分裂绕组d2、平衡绕组p；所述所有绕组的上、下两端分别设有上压板和下托板；所述调压绕组T的上、下两端分别设置成型角环I,所述高压绕组G的上、下两端分别设置有成型角环II、成型角环III、成型角环IV和出线角环V，低压分裂绕组d2的上、下两端分别设置成型角环VI。本发明结构更加简单、排列更加紧密、套装方便，能够有效减小变压器器身的尺寸，缩减变压器体积，节约原材料消耗，降低成本。 【EN】The invention discloses a multi-winding split transformer, which comprises a transformer iron core, wherein a low-voltage split winding d1, a voltage regulating winding T, a high-voltage winding G, a low-voltage split winding d2 and a balance winding p are sequentially arranged on the transformer iron core from inside to outside; the upper end and the lower end of each winding are respectively provided with an upper pressing plate and a lower supporting plate; the upper and lower both ends of voltage regulating winding T set up shaping angle ring I respectively, the upper and lower both ends of high-voltage winding G are provided with shaping angle ring II, shaping angle ring III, shaping angle ring IV and the angle ring V of being qualified for the next round of competitions respectively, and the upper and lower both ends of low pressure split winding d2 set up shaping angle ring VI respectively. The transformer body is simpler in structure, more compact in arrangement and convenient to assemble, the size of the transformer body can be effectively reduced, the size of the transformer is reduced, the consumption of raw materials is saved, and the cost is reduced.

摘要：【中文】本发明公开了一种自耦变压器，包括铁心柱I和铁心柱II，其特征在于：所述铁心柱I和铁心柱II上分别设有若干绕组，所述铁心柱I上的绕组包括绕组B2、绕组A1和绕组B3，且绕组B2、绕组A1和绕组B3在铁芯柱I上由内向外依次排列，所述铁心柱II上的绕组包括绕组A2、绕组B1、绕组A3，且绕组A2、绕组B1、绕组A3在铁心柱II上由内向外依次排列，所述铁心柱I和铁心柱II上绕组的上下两端分别设有带有出线通道的上压板和带有出线通道的下托板。本发明结构更加简单、排列更加紧密、套装方便，能够有效减小自耦变压器的体积，并且提高了电气及机械强度。 【EN】The invention discloses an autotransformer, which comprises a core limb I and a core limb II, and is characterized in that: be equipped with a plurality of windings on core limb I and the core limb II respectively, the winding on the core limb I includes winding B2, winding A1 and winding B3, and winding B2, winding A1 and winding B3 arrange in proper order from inside to outside on core limb I, the last winding of core limb II includes winding A2, winding B1, winding A3, and winding A2, winding B1, winding A3 arrange in proper order from inside to outside on core limb II, the upper and lower both ends of winding are equipped with the top board that has outlet channel and the bottom plate that has outlet channel respectively on core limb I and the core limb II. The invention has simpler structure, more compact arrangement and convenient assembly, can effectively reduce the volume of the autotransformer and improves the electrical and mechanical strength.

摘要：【中文】本发明涉及一种提高两性霉素B产量的补料控制发酵方法，通过控制发酵体系pH、温度、DO值、葡萄糖浓度和添加外源添加物达到提高提高两性霉素B产量的目的。本发明分阶段发酵调控策略能够提供结节链霉菌一个最佳的菌体生长和产物合成的外部环境，有利于两性霉素B的积累；同时补料调控则通过补料培养基和外源化合物的补料，避免了营养物质在发酵过程中的消耗，后期得不到必要的补充的问题。采用本发明发酵方法，两性霉素B放罐单位可以达到16g/L以上，生产成本较目前的先进水平降低15％左右，所得两性霉素B发酵液中，副产物两性霉素A下降了30％以上，降低了后期分离纯化的难度。 【EN】The invention relates to a feeding control fermentation method for improving the yield of amphotericin B, which achieves the purpose of improving the yield of amphotericin B by controlling the pH, the temperature, the DO value and the glucose concentration of a fermentation system and adding exogenous additives. The staged fermentation regulation strategy can provide an optimal external environment for growth of the streptomyces tubercle and synthesis of the product, and is beneficial to accumulation of amphotericin B; meanwhile, the feeding regulation and control avoids the problems that nutrient substances are consumed in the fermentation process and necessary supplement cannot be obtained in the later period through feeding of the feeding culture medium and the exogenous compound. By adopting the fermentation method, the amphotericin B can be put in a tank unit of more than 16g/L, the production cost is reduced by about 15 percent compared with the current advanced level, the by-product amphotericin A in the obtained amphotericin B fermentation liquor is reduced by more than 30 percent, and the difficulty of later-stage separation and purification is reduced.

摘要：【中文】本发明提供一种基于级联拓扑的多电机立体展示装置，包括装置本体，装置本体包括电机组件、级联板以及主控组件，级联板包括若干安装孔，若干电机组件固定安装于安装孔内；主控组件根据输入的图像像素发送指令给若干电机组件，以使得输入的图像通过若干电机组件不同的运动方式获得立体展示。本发明通过微型电机带动展示面板前后移动，进而模拟输入图像的一个像素点的运动，将多个电机进行级联并固定在一个大的级联板上，通过对输入图像像素点灰度值的解析进而控制对应像素电机组件的前后移动来模拟整幅图像的立体展示效果，具有冲击感的立体效果，创造性的颠覆了传统的平面展示宣传的效果。 【EN】The invention provides a multi-motor three-dimensional display device based on a cascade topology, which comprises a device body, wherein the device body comprises motor components, a cascade plate and a main control component, the cascade plate comprises a plurality of mounting holes, and the motor components are fixedly arranged in the mounting holes; the main control assembly sends instructions to the motor assemblies according to the input image pixels so that the input images can be displayed in a three-dimensional mode through different movement modes of the motor assemblies. The display panel is driven by the micro motor to move back and forth, so that the motion of one pixel point of an input image is simulated, the motors are cascaded and fixed on a large cascade plate, the gray value of the pixel point of the input image is analyzed, and the back and forth movement of the corresponding pixel motor component is controlled to simulate the three-dimensional display effect of the whole image, so that the display panel has the three-dimensional effect of impact feeling, and the traditional effect of plane display propaganda is subverted creatively.

摘要：【中文】本发明涉及一种重组R‑ω‑转氨酶及突变体，以及其在不对称合成西他列汀中的应用。本发明筛选新型R‑ω‑转氨酶，并与现有的高效转氨酶重组，获得的重组体的氨基酸序列如SEQ ID:15所示，其突变体是将SEQ ID:15所示的氨基酸序列的第71、135、或292中的一个或者多个进行单位点突变或多位点突变获得的，最佳的R‑ω‑转氨酶突变株的氨基酸序列如SEQ ID:17所示，对应的核苷酸序列如SEQ ID:18所示。本发明提供了具有更高活性(582.4U/g)和立体选择性(e.e.值99.9％)的R‑ω‑TA突变体，可催化500mM底物转化为西他列汀，转化率高达99％，对于提升西他列汀生物催化制备技术具有重要意义。 【EN】The invention relates to a recombinant R-omega-transaminase and a mutant thereof, and application of the recombinant R-omega-transaminase and the mutant in asymmetric synthesis of sitagliptin. The invention screens novel R-omega-transaminase and recombines with the prior high-efficiency transaminase, the obtained recombinant has an amino acid sequence shown in SEQ ID:15, the mutant is obtained by carrying out single-site mutation or multi-site mutation on one or more of 71 th, 135 th or 292 th amino acid sequences shown in the SEQ ID:15, the optimal amino acid sequence of the R-omega-transaminase mutant is shown in the SEQ ID:17, and the corresponding nucleotide sequence is shown in the SEQ ID: 18. The invention provides the R-omega-TA mutant with higher activity (582.4U/g) and stereoselectivity (e.e. value 99.9%), which can catalyze 500mM substrate to be converted into sitagliptin, the conversion rate is up to 99%, and the R-omega-TA mutant has important significance for improving the sitagliptin biocatalytic preparation technology.