摘要：【中文】本发明提出了一种基于级联U型波导嵌套微环的硅基折射率传感器，自下而上依次由层叠的硅衬底层、二氧化硅下包层、单晶硅芯层、二氧化硅上包层构成，所述的单晶硅芯层中的第一直波导的输出与第一U型波导的输入相连，第一U型波导的输出与第二直波导的输入相连，第二直波导的输出与第二U型波导的输入相连，第二U型波导的输出与第三直波导的输入相连；第一微环谐振腔位于第一U型波导内侧的第一直波导与第二直波导之间，第二微环谐振腔位于第二U型波导内侧的第二直波导与第三直波导之间。与同尺寸级联微环型传感器相比，所述结构能够在提高传感灵敏度的基础上，将传感检测范围提高一倍。具有灵敏度高，传感范围大，利于片上集成等优点。 【EN】The invention provides a silicon-based refractive index sensor based on a cascading U-shaped waveguide nested micro-ring, which consists of a silicon substrate layer, a silicon dioxide lower cladding, a monocrystalline silicon core layer and a silicon dioxide upper cladding which are stacked from bottom to top in sequence, wherein the output of a first straight waveguide in the monocrystalline silicon core layer is connected with the input of a first U-shaped waveguide, the output of the first U-shaped waveguide is connected with the input of a second straight waveguide, the output of the second straight waveguide is connected with the input of a second U-shaped waveguide, and the output of the second U-shaped waveguide is connected with the input of a third straight waveguide; the first micro-ring resonant cavity is positioned between the first straight waveguide and the second straight waveguide on the inner side of the first U-shaped waveguide, and the second micro-ring resonant cavity is positioned between the second straight waveguide and the third straight waveguide on the inner side of the second U-shaped waveguide. Compared with the cascade micro-ring sensor with the same size, the structure can double the sensing detection range on the basis of improving the sensing sensitivity. The sensor has the advantages of high sensitivity, wide sensing range, contribution to on-chip integration and the like.

摘要：【中文】本发明公开了用于手性粒子光学检测和分选的装置及方法,装置由激光器、非偏振分光棱镜、反射镜、矢量光场生成系统、计算机和高数值孔径物镜组成；方法通过计算机控制矢量光场生成系统，将激光器发出的激光裁剪为具有特定空间分布的矢量光场，并利用高数值孔径物镜将其聚焦，在物镜焦场区域生成横向自旋横向光针焦场。当手性粒子与横向自旋横向光针焦场相互作用时，作用在粒子上的非手性梯度力被光针焦场抑制，且不同手性的粒子将在手性梯度力的作用下被捕获在光针焦场的不同位置，并以不同的频率在捕获位置发生自转。本发明不仅可以实现对分子手性的探测，而且能够无损伤地对手性粒子进行分选，在一系列涉及手性光学的领域都有着广阔的应用前景。 【EN】The invention discloses a device and a method for optical detection and sorting of chiral particles, wherein the device consists of a laser, a non-polarizing beam splitter prism, a reflector, a vector light field generating system, a computer and an objective lens with a high numerical aperture; the method cuts laser emitted by a laser into a vector light field with specific spatial distribution by controlling a vector light field generating system through a computer, focuses the vector light field by using an objective lens with a high numerical aperture, and generates a transverse spinning transverse optical needle focal field in an objective lens focal field area. When the chiral particles interact with the transverse spinning transverse optical needle focal field, the achiral gradient force acting on the particles is inhibited by the optical needle focal field, and the particles with different chiralities are captured at different positions of the optical needle focal field under the action of the chiral gradient force and rotate at different frequencies at the captured positions. The invention can not only realize the detection of the chirality of the molecule, but also can sort the chiral particles without damage, and has wide application prospect in a series of fields relating to chiral optics.

摘要：【中文】本发明公布了一种频率可调谐倍频三角波、方波的产生装置及方法，所述装置包括激光器，第一偏振控制器，第一强度调制器（MZM1），微波源，微波功分器，第一电压源，第二偏振控制器，偏振分束器，第二强度调制器（MZM2），微波放大器，第二电压源，偏振合束器，光电探测器，90°移相器。所述方法如下：激光经MZM1调制产生±1阶光边带，此信号经偏振分束器分成两束偏振态相互垂直的光，一路进入MZM2调制后产生±3阶光边带。两路光信号经偏振合束器后送入光电探测器，分别拍频得二次、六次谐波，通过调节二者幅度比，即可产生倍频三角波、方波。本发明不需要滤波器、倍频器等复杂器件，具有系统复杂度低、成本低、可调性好、可调谐范围大、易于实现等优点。 【EN】The invention discloses a device and a method for generating frequency-tunable frequency-doubled triangular waves and square waves, wherein the device comprises a laser, a first polarization controller, a first intensity modulator (MZM 1), a microwave source, a microwave power divider, a first voltage source, a second polarization controller, a polarization beam splitter, a second intensity modulator (MZM 2), a microwave amplifier, a second voltage source, a polarization beam combiner, a photoelectric detector and a 90-degree phase shifter. The method comprises the following steps: laser is modulated by MZM1 to generate +/-1 order light sidebands, the signal is divided into two beams of light with mutually vertical polarization states by a polarization beam splitter, and one beam enters MZM2 to be modulated to generate +/-3 order light sidebands. The two optical signals are sent into the photoelectric detector after passing through the polarization beam combiner, the second harmonic and the sixth harmonic are obtained by beating frequency respectively, and the frequency multiplication triangular wave and the frequency multiplication square wave can be generated by adjusting the amplitude ratio of the two. The invention does not need complex devices such as a filter, a frequency multiplier and the like, and has the advantages of low system complexity, low cost, good adjustability, large tunable range, easy realization and the like.

摘要：【中文】本发明提供了一种适用于仿生叶片泵几何参数的低噪声优化方法，包括如下步骤：确定优化变量为：凹坑直径、凹坑流向间距、凹坑展向间距；确定优化目标为：总声压级；确定优化变量的取值范围；确定样本水平数，将优化变量作为因素，制作因素水平的均匀设计表；根据均匀设计表，随机确定测试样本；根据测试样本进行数值模拟与声学计算，确定凹坑布置位置；根据均匀设计表建立样本数据库，获得预测模型；基于神经网络预测模型利用粒子群优化算法进行寻优求解，将总声压级值作为适应度值，计算得到总声压级最小时优化变量的取值。本发明可以获得合理的优化变量，并提出了合适的取值范围确定方法，实现了现代优化算法在仿生叶片泵中的应用。 【EN】The invention provides a low-noise optimization method suitable for geometric parameters of a bionic vane pump, which comprises the following steps of: determining the optimization variables as follows: the diameter of the pits, the flow direction spacing of the pits and the spanwise spacing of the pits; determining an optimization objective as follows: a total sound pressure level; determining the value range of the optimization variable; determining the level number of samples, taking the optimized variables as factors, and making a uniform design table of the factor level; randomly determining a test sample according to the uniform design table; carrying out numerical simulation and acoustic calculation according to the test sample, and determining the arrangement position of the pits; establishing a sample database according to the uniform design table to obtain a prediction model; and performing optimization solution by utilizing a particle swarm optimization algorithm based on a neural network prediction model, taking the total sound pressure level value as a fitness value, and calculating to obtain the value of the optimization variable when the total sound pressure level is minimum. The invention can obtain reasonable optimization variables, provides a proper value range determination method and realizes the application of the modern optimization algorithm in the bionic vane pump.

摘要：【中文】本发明公开了一种荧光可调的Mn掺杂CsPb₂Cl_xBr_5‑x纳米晶的制备方法，制备方法包括如下步骤：（1）PbBr₂前驱体和己胺溴配体溶液制备；（2）MnCl₂前驱体的制备；（3）CsBr前驱体的制备：（4）Mn掺杂的CsPb₂Cl_xBr_5‑x纳米晶的制备。本发明采用常温一锅法合成钙钛矿纳米晶，其制备工艺简单，光谱可调控，最终可得到具有白光发射能力的Mn掺杂的CsPb₂Cl_xBr_5‑x纳米晶材料。 【EN】The invention discloses a Mn-doped CsPb with adjustable fluorescence₂Cl_xBr_5‑xThe preparation method of the nanocrystalline comprises the following steps: (1) PbBr₂Preparing a precursor and a hexylamine bromine ligand solution; (2) MnCl₂Preparing a precursor; (3) preparation of CsBr precursor: (4) mn doped CsPb₂Cl_xBr_5‑xAnd (4) preparing the nano crystal. The invention adopts a normal temperature one-pot method to synthesize the perovskite nanocrystalline, the preparation process is simple, the spectrum can be regulated and controlled, and finally the Mn-doped CsPb with white light emission capability can be obtained₂Cl_xBr_5‑xA nanocrystalline material.

摘要：【中文】本发明公开了一种基于二氧化硅的超分辨成像探针及其制备方法和应用，该超分辨成像探针为连接了Alexa Fluor 647染料的二氧化硅纳米粒子，并且其表面偶联了HER2（人表皮生长因子受体‑2）核酸适配体；该探针能靶向识别过表达HER2的细胞外泌体，即对过表达HER2的细胞外泌体进行荧光标记；利用超高分辨率显微镜即可对特异性识别该探针的细胞外泌体进行超分辨光学成像；该探针粒径均一，尺寸较小，定位精度高，闪烁性能优良，适用于基于单分子定位法的超高分辨率光学成像；本发明实现了超分辨成像探针对于外泌体的标记，利用单分子定位显微镜，通过双通道共定位的方式，能够实现对细胞外泌体的准确标记。 【EN】The invention discloses a silicon dioxide-based super-resolution imaging probe and a preparation method and application thereof, wherein the super-resolution imaging probe is a silicon dioxide nano particle connected with Alexa Fluor647 dye, and the surface of the super-resolution imaging probe is coupled with HER2 (human epidermal growth factor receptor-2) aptamer; the probe can target and recognize cell exosomes over-expressing HER2, namely, the cell exosomes over-expressing HER2 are fluorescently labeled; the cell exosome of the probe can be specifically identified by using an ultrahigh resolution microscope to carry out super-resolution optical imaging; the probe has the advantages of uniform particle size, small size, high positioning precision and excellent scintillation performance, and is suitable for ultrahigh-resolution optical imaging based on a single-molecule positioning method; the invention realizes the marking of exosome by the super-resolution imaging probe, and can realize the accurate marking of the cell exosome by utilizing a single-molecule positioning microscope and a double-channel co-positioning mode.

摘要：【中文】本发明公开了一种Bcr‑Abl融合蛋白检测方法，该方法中捕获磁球和SERS探针分别与Bcr‑Abl融合蛋白发生特异性结合，再通过SERS光谱成像检测技术检测SERS信号，来检测Bcr‑Abl融合蛋白。该检测方法灵敏度大，精确度高。 【EN】The invention discloses a Bcr-Abl fusion protein detection method, wherein a capture magnetic sphere and an SERS probe are respectively specifically combined with Bcr-Abl fusion protein, and an SERS signal is detected by an SERS spectral imaging detection technology to detect the Bcr-Abl fusion protein. The detection method has high sensitivity and high accuracy.

摘要：【中文】本发明公开了一种免疫荧光共定位成像平台的制备方法和应用，该检测平台通过电子束光刻技术生成金纳米阵列图案，在其表面通过金硫键偶联带有荧光基团FAM的HER2（人表皮生长因子受体‑2）核酸适配体。该平台能够特异性捕获HER2高表达的肿瘤细胞分泌的外泌体；成像链为带有另一种荧光基团Cy5的HER2核酸适配体探针；两种探针均具有荧光闪烁特性，可用于超分辨单分子定位成像（SMLM）；通过SMLM成像技术，即可对捕获的外泌体进行超分辨光学成像；结合双色荧光共定位技术，可以在单分子水平上判断假阳性事件，提高三明治免疫检测技术的准确性。 【EN】The invention discloses a preparation method and application of an immunofluorescence co-localization imaging platform, wherein a gold nano array pattern is generated on the detection platform through an electron beam lithography technology, and a HER2 (human epidermal growth factor receptor-2) aptamer with a fluorescent group FAM is coupled on the surface of the gold nano array pattern through a gold-sulfur bond. The platform can specifically capture exosomes secreted by tumor cells with high expression of HER 2; the imaging chain is a HER2 aptamer probe with another fluorescent group Cy 5; both the two probes have the fluorescent scintillation characteristic and can be used for super-resolution single molecule positioning imaging (SMLM); the captured exosome can be subjected to super-resolution optical imaging by an SMLM imaging technology; by combining the double-color fluorescence co-localization technology, the false positive event can be judged on the single molecule level, and the accuracy of the sandwich immunoassay technology is improved.

摘要：【中文】一种3D打印个性化牙周组织再生材料的方法，利用术前锥形束计算机断层摄影CBCT设备获取牙周骨缺损患者的骨缺损形态数据，根据所述骨缺损形态数据确定植骨形态数据，并根据所述植骨形态数据确定其形态切片处理数据和用于3D打印的原料，然后利用所述形态切片处理数据和原料通过熔融沉积成型FDM三维打印机打印出个性化牙周组织再生材料，有利于方便医生操作并实现较为理想的手术效果。 【EN】A3D printing method of an individualized periodontal tissue regeneration material is characterized in that preoperative Cone Beam Computed Tomography (CBCT) equipment is used for obtaining bone defect shape data of a periodontal bone defect patient, bone grafting shape data are determined according to the bone defect shape data, shape slice processing data and raw materials for 3D printing are determined according to the bone grafting shape data, then the individualized periodontal tissue regeneration material is printed out through a Fused Deposition Modeling (FDM) three-dimensional printer by using the shape slice processing data and the raw materials, and the method is beneficial to facilitating operation of doctors and achieving ideal surgical effects.

摘要：【中文】本发明提供了利用飞秒光镊和光场调控表征微纳粒子双光子吸收效应的装置和方法，将待测粒子浸没在线性溶剂中,后置于载玻片上；激光器作为光源输出的线偏振光经光场调控装置生成涡旋光束，光束经分光棱镜后进入显微物镜，通过透镜紧聚焦在载玻片上，生成的特定光场与载玻片上粒子相互作用，使得粒子能够在捕获平面上内做圆周运动。根据被捕获粒子做圆周运动的频率与入射光功率之间的依赖关系，可以判断出微纳粒子是否具有双光子吸收效应。并可进一步从运动频率与入射光功率之间的非线性依赖关系，可以获得单个微纳粒子的双光子吸收系数。本发明实现双光子吸收效应的“可视化”鉴别以及粒子双光子吸收系数的测量，装置简单、操作方便，所需样品少。 【EN】The invention provides a device and a method for representing a two-photon absorption effect of micro-nano particles by utilizing femtosecond optical tweezers and optical field regulation, wherein the particles to be detected are immersed in a linear solvent and then placed on a glass slide; linearly polarized light output by a laser as a light source generates vortex light beams through a light field regulating device, the light beams enter a microscope objective after passing through a beam splitter prism, and are tightly focused on a glass slide through a lens, and the generated specific light field interacts with particles on the glass slide, so that the particles can do circular motion on a capture plane. And judging whether the micro-nano particles have a two-photon absorption effect or not according to the dependence relationship between the frequency of the captured particles performing circular motion and incident light power. And further, the two-photon absorption coefficient of a single micro-nano particle can be obtained from the nonlinear dependence relationship between the motion frequency and the incident light power. The invention realizes the visual identification of the two-photon absorption effect and the measurement of the two-photon absorption coefficient of the particles, and has the advantages of simple device, convenient operation and less required samples.