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1:
[发明]
【中文】一种血样检测系统 【EN】Blood sample detection system
申请号:
201911283082.4
公开号:CN110927085A 主分类号:G01N21/31
申请人:
【中文】循证医疗科技(杭州)有限公司【EN】Evidence based medical technology (Hangzhou) Co., Ltd
申请日:2019.12.13 公开日:2020.03.27
发明人:
【中文】方磊【EN】
Fang Lei
摘要:【中文】本发明涉及一种血样检测系统,所述系统包括壳体和电极卡;所述壳体为一面开口的盒体,所述开口对应的底面的外侧设置有两个凸起,每个所述凸起内设置有通孔;所述通孔穿过所述凸起和底面;所述底面的内侧面上,设置有从一个凸起到另外一个凸起的流道;在所述流道的起点端设置有第一圆形槽部,结束端设置有第二圆形槽部,所述第一圆形槽部的直径大于所述流道的其余部分的最大宽度;所述第一圆形槽部通过流道与一个所述凸起的通孔连接。 【EN】The invention relates to a blood sample detection system, which comprises a shell and an electrode card; the shell is a box body with an opening on one surface, two bulges are arranged on the outer side of the bottom surface corresponding to the opening, and a through hole is formed in each bulge; the through hole penetrates through the protrusion and the bottom surface; a flow channel from one bulge to the other bulge is arranged on the inner side surface of the bottom surface; a first circular groove part is arranged at the starting end of the flow channel, a second circular groove part is arranged at the ending end of the flow channel, and the diameter of the first circular groove part is larger than the maximum width of the rest part of the flow channel; the first circular groove portion is connected with one of the raised through holes through a flow channel.
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2:
[发明]
【中文】一种血样检测方法 【EN】Blood sample detection method
申请号:
201911283112.1
公开号:CN110927086A 主分类号:G01N21/31
申请人:
【中文】循证医疗科技(杭州)有限公司【EN】Evidence based medical technology (Hangzhou) Co., Ltd
申请日:2019.12.13 公开日:2020.03.27
发明人:
【中文】方磊【EN】
Fang Lei
摘要:【中文】本发明涉及一种血样检测方法,所述方法包括:加热电极卡至预设温度;当血样流经第一检测道时,设置多对气泡检测单元对其进行检测;当任一所述第一检测道两侧的气泡检测单元检测到气泡时,计数器增加1;当血样流过所述第一检测道后,使其转动至少60°流入到再分布道;当血样流过所述再分布道后,使其转动至少60°流入道第二检测道;在血样流经第二检测道时,设置与所述第一检测道两侧数量一致的对数的气泡检测单元对其进行检测;当任一所述第二检测道两侧的气泡检测单元检测道气泡时,计数器减少1;当计数器的数值等于0后的第一时间阈值内,0值不变化,控制电极对位于所述再分布道中的血样进行检测。 【EN】The invention relates to a blood sample detection method, which comprises the following steps: heating the electrode card to a preset temperature; when the blood sample flows through the first detection channel, a plurality of pairs of bubble detection units are arranged to detect the blood sample; when the bubble detection units on two sides of any one first detection channel detect bubbles, the counter is increased by 1; after flowing through the first detection channel, rotating the blood sample by at least 60 degrees to flow into the redistribution channel; after the blood sample flows through the redistribution trace, the blood sample is rotated by at least 60 degrees and flows into a second detection trace of the trace; when the blood sample flows through the second detection channel, the bubble detection units with the number of the logarithm consistent with that of the number of the two sides of the first detection channel are arranged to detect the blood sample; when the bubble detection units on two sides of any one second detection channel detect bubbles, the counter is decreased by 1; and when the value of the counter is equal to 0 and within a first time threshold value, the value of 0 is unchanged, and the control electrode detects the blood sample in the redistribution channel.
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3:
[发明]
【中文】一种电化学传感器的制作方法 【EN】Method for manufacturing electrochemical sensor
申请号:
202010013021.2
公开号:CN111077197A 主分类号:G01N27/26
申请人:
【中文】循证医疗科技(杭州)有限公司【EN】Evidence based medical technology (Hangzhou) Co., Ltd
申请日:2020.01.07 公开日:2020.04.28
发明人:
【中文】方磊【EN】
Fang Lei
摘要:【中文】本发明涉及电化学传感器的制作方法,提供一种快速,高品质,价格有竞争力,工艺控制简便并且适合大规模生产的电化学传感器制作方法。制作方法是采用PCB或者其他塑料基底,或者是其他陶瓷基底,或者是其他金属陶瓷基底,使用混合的电镀,厚膜网印,和基于硅片加工的微制造工艺进行电化学传感器的制作。不同的金属材料厚度/精度要求和在传感器上的相对添加顺序会决定工艺的选择。 【EN】The invention relates to a manufacturing method of an electrochemical sensor, and provides a manufacturing method of an electrochemical sensor which is rapid, high in quality, competitive in price, simple and convenient in process control and suitable for large-scale production. The manufacturing method is to adopt a PCB or other plastic substrate, or other ceramic substrate, or other metal ceramic substrate, and use mixed electroplating, thick film screen printing and a micro-manufacturing process based on silicon chip processing to manufacture the electrochemical sensor. The different metal material thickness/accuracy requirements and the relative order of addition on the sensor will determine the process choice.
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4:
[发明]
【中文】基于时间轴的数据展示方法及装置 【EN】Data display method and device based on time axis
申请号:
202010067743.6
公开号:CN111274514A 主分类号:G06F16/957
申请人:
【中文】北京市天元网络技术股份有限公司【EN】METARNET TECHNOLOGIES Co.,Ltd.
申请日:2020.01.20 公开日:2020.06.12
发明人:
【中文】房磊【EN】
Fang Lei
摘要:【中文】本发明实施例提供一种基于时间轴的数据展示方法及装置,所述方法包括:接收上传的配置参数,所述配置参数包含数据参数和告警参数;获取所述告警参数中的数据展示时间,并根据所述数据展示时间创建所述数据参数对应的时间轴;根据预设的告警规则获取所述告警参数对应的告警等级,并根据所述告警等级确定所述时间轴中数据参数的显示效果;将所述时间轴的数据参数以对应的显示效果在web页面进行展示。采用本方法提供了一种灵活的以时间轴形式在web页面展示数据的方法。 【EN】The embodiment of the invention provides a data display method and device based on a time axis, wherein the method comprises the following steps: receiving uploaded configuration parameters, wherein the configuration parameters comprise data parameters and alarm parameters; acquiring data display time in the alarm parameters, and creating a time axis corresponding to the data parameters according to the data display time; acquiring an alarm grade corresponding to the alarm parameter according to a preset alarm rule, and determining the display effect of the data parameter in the time axis according to the alarm grade; and displaying the data parameters of the time axis on a web page with a corresponding display effect. The method provides a flexible method for displaying data on the web page in a time axis form.
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5:
[发明]
【中文】一种线粒体靶向光敏剂Sarm1-mtKR及其制备方法和应用 【EN】Mitochondrial targeting photosensitizer Sarm1-mtKR and preparation method and application thereof
申请号:
202010057161.X
公开号:CN111234030A 主分类号:C07K19/00
申请人:
【中文】吉林大学【EN】Jilin University
申请日:2020.01.19 公开日:2020.06.05
发明人:
【中文】王志成
;
于雷
;
方芳
;
李鑫【EN】Wang Zhicheng
;
Yu Lei
;
Fang Fang
;
Li Xin
摘要:【中文】本发明提供了一种线粒体靶向光敏剂Sarm1‑mtKR及其制备方法和应用,其特征在于:所述线粒体靶向光敏剂Sarm1‑mtKR的融合蛋白序列大小为810bp,序列如SEQ ID NO 1所示;所述制备方法为将Sarm1线粒体定位信号序列构建到KillerRed(KR)序列的上游,形成融合蛋白表达载体Sarm1‑mtKR。本发明的有益之处在于:本发明提供的一种线粒体靶向光敏剂Sarm1‑mtKR具有在线粒体内定位,并表达蛋白的功能,而且在光照后导致活性氧ROS的爆发式生成,增强辐射诱导的线粒体失能以及凋亡和自噬,从而发挥光敏剂的作用,增强了肿瘤的光动力治疗和放疗的联合应用效果。 【EN】The invention provides a mitochondrion targeting photosensitizer Sarm1-mtKR and a preparation method and application thereof, and is characterized in that: the size of the fusion protein sequence of the mitochondrion targeted photosensitizer Sarm1-mtKR is 810bp, and the sequence is shown as SEQ ID NO 1; the preparation method comprises the step of constructing a Sarm1 mitochondrion positioning signal sequence to the upstream of a KillerRed (KR) sequence to form a fusion protein expression vector Sarm 1-mtKR. The invention has the advantages that: the mitochondrial targeting photosensitizer Sarm1-mtKR provided by the invention has the functions of positioning in mitochondria and expressing protein, and can cause the explosive generation of Reactive Oxygen Species (ROS) after illumination, and enhance the mitochondrial incapability induced by radiation, apoptosis and autophagy, thereby playing the role of the photosensitizer and enhancing the combined application effect of photodynamic therapy and radiotherapy of tumors.
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6:
[发明]
【中文】一种基于文本信息的辅助说话人分离方法及相关装置 【EN】Text information-based auxiliary speaker separation method and related device
申请号:
201911424875.3
公开号:CN111128223A 主分类号:G10L21/0272
申请人:
【中文】科大讯飞股份有限公司【EN】IFLYTEK Co.,Ltd.
申请日:2019.12.30 公开日:2020.05.08
发明人:
【中文】方昕
;
柳林
;
刘海波
;
方磊【EN】Fang Xin
;
Liu Lin
;
Liu Haibo
;
Fang Lei
摘要:【中文】本申请实施例公开了一种基于文本信息的辅助说话人分离方法及相关装置,方法包括:获取待分离的第一语音信息;对待分离的第一语音信息进行第一分离处理,得到第一分离结果,第一分离处理是指对第一语音信息中的不同说话人进行初步分割和聚类;对第一分离结果进行语音处理,得到第二语音信息,语音处理包括语音识别或语音表征信息采集;将第二语音信息输入预先训练好的说话人转变点识别模型,确定第二语音信息中的说话人的转变点;根据说话人的转变点和第一分离结果得到目标分离结果。可见,本申请通过获取的第一语音信息获取文本信息,融合底层声学特征与文本信息进行说话人分离,提高说话人分离的准确性。 【EN】The embodiment of the application discloses a method for assisting speaker separation based on text information and a related device, wherein the method comprises the following steps: acquiring first voice information to be separated; carrying out first separation processing on first voice information to be separated to obtain a first separation result, wherein the first separation processing refers to primary segmentation and clustering of different speakers in the first voice information; performing voice processing on the first separation result to obtain second voice information, wherein the voice processing comprises voice recognition or voice representation information acquisition; inputting the second voice information into a pre-trained speaker transition point identification model, and determining the speaker transition point in the second voice information; a target separation result is obtained based on the transition point of the speaker and the first separation result. Therefore, the text information is obtained through the obtained first voice information, the bottom acoustic characteristics and the text information are fused to separate the speaker, and accuracy of speaker separation is improved.
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7:
[发明]
【中文】获得讯询问话题分类模型、讯询问话题分类的方法和装置 【EN】Method and device for obtaining query topic classification model and query topic classification
申请号:
201911422174.6
公开号:CN111159360A 主分类号:G06F16/33
申请人:
【中文】合肥讯飞数码科技有限公司【EN】HEFEI USTC IFLYTEK Co.,Ltd.
申请日:2019.12.31 公开日:2020.05.15
发明人:
【中文】杨帆
;
方磊
;
方四安
;
方昕
;
徐承【EN】Yang Fan
;
Fang Lei
;
Fang Sian
;
Fang Xin
;
Xu Cheng
摘要:【中文】本申请公开了一种获得讯询问话题分类模型、讯询问话题分类的方法和装置,该方法包括:首先,对样本讯询问笔录中样本问答对进行自然语言预处理,获得各个样本问句分词和各个样本答句分词;然后,根据各个样本问句分词及其对应的各个贡献度得分、各个样本答句分词及其对应的各个贡献度得分和样本问答对的标记话题类别,训练基于注意力机制的卷积神经网络获得讯询问话题分类模型。由此可见,通过贡献度得分增加样本问答对的话题类别信息,加强讯询问话题分类的训练;且利用基于注意力机制的卷积神经网络,能够充分学习“强话题”分词与话题类别之间的关系,使得讯询问话题分类模型的话题分类效果更好,提高后续讯询问话题分类的正确率。 【EN】The application discloses a method and a device for obtaining a news query topic classification model and a news query topic classification, wherein the method comprises the following steps: firstly, carrying out natural language preprocessing on sample question-answer pairs in a sample news inquiry record to obtain each sample question sentence participle and each sample answer sentence participle; then, training a convolutional neural network based on an attention mechanism to obtain a signal query topic classification model according to each sample question word and each corresponding contribution degree score thereof, each sample answer sentence word and each corresponding contribution degree score thereof and the labeled topic category of the sample question-answer pair. Therefore, the topic category information of the sample question-answer pair is increased through the contribution degree score, and the training of the news inquiry topic classification is enhanced; and the convolutional neural network based on the attention mechanism can fully learn the relationship between the word segmentation of the 'strong topic' and the topic category, so that the topic classification effect of the topic classification model for the inquiry signal is better, and the accuracy of the subsequent topic classification for the inquiry signal is improved.
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8:
[发明]
【中文】训练数据选择方法、装置、电子设备及计算机存储介质 【EN】Training data selection method and device, electronic equipment and computer storage medium
申请号:
201911342455.0
公开号:CN111081221A 主分类号:G10L15/06
申请人:
【中文】合肥讯飞数码科技有限公司【EN】HEFEI USTC IFLYTEK Co.,Ltd.
申请日:2019.12.23 公开日:2020.04.28
发明人:
【中文】方磊
;
夏静雯
;
杨军
;
方昕
;
方四安【EN】
Fang Lei
;
Xia Jingwen
;
Yang Jun
;
Fang Xin
;
Fang Sian
摘要:【中文】本申请提供了一种训练数据选择方法、装置、电子设备及计算机存储介质,首先将备选语料库中的备选声学特征数据输入基础声学模型,根据所述基础声学模型的输出确定所述备选声学特征数据对应的后验概率数据;接着,根据所述后验概率数据计算所述备选声学特征数据对应的信息熵数据;然后,根据所述信息熵数据确定所述备选声学特征数据对应的相对熵数据;最后,根据所述相对熵数据从所述备选声学特征数据中选取训练数据。可以根据信息熵数据和相对熵数据来选取对模型而言信息量较大的训练数据,从而实现少量优选的训练数据的训练效果也能满足模型的训练需求,减少对无用训练数据的重复标注,大大节省了人力物力。 【EN】The application provides a training data selection method, a training data selection device, electronic equipment and a computer storage medium, wherein firstly, alternative acoustic feature data in an alternative corpus are input into a basic acoustic model, and posterior probability data corresponding to the alternative acoustic feature data are determined according to the output of the basic acoustic model; then, calculating information entropy data corresponding to the alternative acoustic characteristic data according to the posterior probability data; then, determining relative entropy data corresponding to the alternative acoustic characteristic data according to the information entropy data; and finally, selecting training data from the alternative acoustic feature data according to the relative entropy data. Training data with large information quantity for the model can be selected according to the information entropy data and the relative entropy data, so that the training effect of a small amount of optimized training data can meet the training requirement of the model, repeated marking of useless training data is reduced, and manpower and material resources are greatly saved.
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9:
[发明]
【中文】一种具有低马氏体含量的高强度和高塑性304奥氏体不锈钢的制备方法 【EN】Preparation method of high-strength and high-plasticity 304 austenitic stainless steel with low martensite content
申请号:
201911043937.6
公开号:CN110923430A 主分类号:C21D7/10
申请人:
【中文】中国科学院金属研究所【EN】INSTITUTE OF METAL RESEARCH CHINESE ACADEMY OF SCIENCES
申请日:2019.10.30 公开日:2020.03.27
发明人:
【中文】卢磊
;
潘庆松
;
崔方【EN】Lu Lei
;
Pan Qingsong
;
Cui Fang
摘要:【中文】本发明公开了一种具有低马氏体含量的高强度和高塑性304奥氏体不锈钢的制备方法,属于金属材料强化技术领域。该方法通过对粗晶304不锈钢棒材或管材进行小角度循环往复扭转变形处理,从而在304不锈钢的原始粗晶结构中引入梯度分布的位错和纳米孪晶变形微结构,同时在材料表层的马氏体组织含量低于7%;所述小角度循环扭转变形处理是指:将棒材或管材的一端固定,并施加力使棒材或管材的另一端绕其中心轴往复旋转,往复旋转一次为一个循环扭转周次。与相同成分的均匀粗晶结构相比,经过循环往复扭转工艺处理后的金属材料的屈服强度提高1.5倍以上,并且具有与粗晶相当的均匀塑性。 【EN】The invention discloses a preparation method of high-strength and high-plasticity 304 austenitic stainless steel with low martensite content, and belongs to the technical field of metal material strengthening. The method comprises the steps of performing small-angle circular reciprocating torsional deformation treatment on a coarse grain 304 stainless steel bar or pipe, so that a dislocation and nanometer twin deformation microstructure in gradient distribution is introduced into an original coarse grain structure of 304 stainless steel, and the martensite structure content on the surface layer of the material is lower than 7%; the small-angle cyclic torsional deformation treatment is as follows: one end of the bar or the pipe is fixed, force is applied to enable the other end of the bar or the pipe to rotate around the central axis in a reciprocating mode, and the cycle of the reciprocating rotation is one cycle of the twisting. Compared with a uniform coarse-grain structure with the same components, the yield strength of the metal material treated by the cyclic reciprocating torsion process is improved by more than 1.5 times, and the metal material has uniform plasticity equivalent to that of coarse grains.
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10:
[发明]
【中文】一种提高金属材料力学性能的循环扭转加工工艺 【EN】Circular torsion machining process for improving mechanical property of metal material
申请号:
201911044516.5
公开号:CN110923438A 主分类号:C21D10/00
申请人:
【中文】中国科学院金属研究所【EN】INSTITUTE OF METAL RESEARCH CHINESE ACADEMY OF SCIENCES
申请日:2019.10.30 公开日:2020.03.27
发明人:
【中文】卢磊
;
潘庆松
;
崔方【EN】Lu Lei
;
Pan Qingsong
;
Cui Fang
摘要:【中文】本发明公开了一种提高金属材料力学性能的循环扭转加工工艺,属于金属材料强化技术领域。具体是通过对金属棒材、管材或板材样品施加小角度循环往复扭转变形,通过在金属材料表面至内部产生梯度分布的剪切塑形应变,从而引入梯度分布的位错和纳米孪晶等变形微结构,并且保留原始态的粗晶结构。其中,扭转角振幅介于2度和30度之间,循环扭转周次介于2和200之间。与相同成分的均匀粗晶结构相比,经过循环往复扭转工艺处理后的金属材料的屈服强度提高1.5倍以上,并且具有与粗晶相当的均匀塑性。利用本发明在原始粗晶中获得具有梯度分布微结构具有高强度和良好塑性匹配。 【EN】The invention discloses a circular torsion processing technology for improving mechanical properties of a metal material, and belongs to the technical field of metal material reinforcement. Specifically, small-angle cyclic reciprocating torsional deformation is applied to a metal bar, pipe or plate sample, and gradient-distributed shear plastic strain is generated from the surface to the inside of a metal material, so that gradient-distributed deformation microstructures such as dislocation and nanometer twin crystal are introduced, and an original coarse crystal structure is retained. Wherein the torsion angle amplitude is between 2 degrees and 30 degrees, and the cycle torsion frequency is between 2 and 200. Compared with a uniform coarse-grain structure with the same components, the yield strength of the metal material treated by the cyclic reciprocating torsion process is improved by more than 1.5 times, and the metal material has uniform plasticity equivalent to that of coarse grains. The microstructure with gradient distribution obtained in the original coarse crystal by the method has high strength and good plasticity matching.
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