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Gao Jinke
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1:
[发明]
【中文】一种基于基因干扰载体和铁纳米粒子用于杀灭癌细胞的组合物及其应用 【EN】Composition for killing cancer cells based on gene interference vector and iron nanoparticles and application thereof
申请号:
202010173472.2
公开号:CN111249477A 主分类号:A61K48/00
申请人:
【中文】东南大学【EN】SOUTHEAST University
申请日:2020.03.12 公开日:2020.06.09
发明人:
【中文】王进科
;
高金良
;
罗涛【EN】Wang Jinke
;
Gao Jinliang
;
Luo Tao
摘要:【中文】本发明公开了一种基于基因干扰载体和铁纳米粒子用于杀灭癌细胞的组合物及其应用,该组合物包括基因干扰载体和铁纳米粒子,所述基因干扰载体为癌细胞特异性启动子DMP控制的CRISPR/Cas13a表达载体或microRNA表达载体,该载体所表达的Cas13a‑gRNA或microRNA可靶向抑制细胞内铁代谢及活性氧相关基因的表达,其中铁纳米粒子进入细胞后可降解产生铁离子、升高活性氧水平。本发明在基因干扰载体和铁纳米粒子共同作用下,可导致癌细胞内铁离子及活性氧水平急剧升高,诱发癌细胞发生显著的铁凋亡,本发明的提出的基因干扰载体和铁纳米粒子组合可用于制备新型癌症治疗试剂。 【EN】The invention discloses a composition for killing cancer cells based on a gene interference vector and iron nanoparticles and application thereof, wherein the composition comprises the gene interference vector and the iron nanoparticles, the gene interference vector is a CRISPR/Cas13a expression vector or a microRNA expression vector controlled by a cancer cell specific promoter DMP, Cas13a-gRNA or microRNA expressed by the vector can target and inhibit iron metabolism in cells and expression of active oxygen related genes, and the iron nanoparticles can be degraded to generate iron ions and increase the level of active oxygen after entering the cells. Under the combined action of the gene interference vector and the iron nanoparticles, the invention can lead the iron ion and reactive oxygen level in cancer cells to be increased rapidly and induce the cancer cells to generate obvious iron apoptosis.
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2:
[发明]
【中文】一种管道式组合型污水自动过滤装置及方法 【EN】Pipeline type combined automatic sewage filtering device and method
申请号:
201911327274.0
公开号:CN111013247A 主分类号:B01D36/02
申请人:
【中文】中国石油化工股份有限公司
;
中国石油化工股份有限公司胜利油田分公司石油工程技术研究院【EN】China Petroleum & Chemical Corp.
;
RESEARCH INSTITUTE OF PETROLEUM ENGINEERING, SINOPEC SHENGLI OILFIELD BRANCH
申请日:2019.12.20 公开日:2020.04.17
发明人:
【中文】安申法
;
于滨
;
高生伟
;
杨斌
;
王刚
;
王玉江
;
郝金克
;
马继良
;
朱秀娟
;
刘文胜【EN】An Shenfa
;
Yu Bin
;
Gao Shengwei
;
Yang Bin
;
Wang Gang
;
Wang Yujiang
;
Hao Jinke
;
Ma Jiliang
;
Zhu Xiujuan
;
Liu Wensheng
摘要:【中文】本发明属于污水处理技术领域,具体涉及油田采出水处理系统,特别涉及一种管道式组合型污水自动过滤装置及方法。该装置包括过滤单元、过滤进水单元、过滤出水单元、反洗进水单元、反洗出水单元、排污单元、控制单元;所述的过滤进水单元、过滤出水单元、反洗进水单元、反洗出水单元和排污单元与过滤单元相连接,控制器控制过滤单元、过滤进水单元、过滤出水单元、反洗进水单元、反洗出水单元和排污单元。本发明过滤单元的数量与布局以及过滤器的数量可以根据试验场地的大小和形状确定,解决了过滤器现场安装和布局受到限制的问题;本发明过滤单元的反冲洗以及滤网和滤料更换独立进行,且不影响其它过滤单元的过滤,保证了整个污水处理的连续性。 【EN】The invention belongs to the technical field of sewage treatment, particularly relates to an oilfield produced water treatment system, and particularly relates to a pipeline type combined automatic sewage filtering device and method. The device comprises a filtering unit, a filtering water inlet unit, a filtering water outlet unit, a backwashing water inlet unit, a backwashing water outlet unit, a sewage discharge unit and a control unit; the filter water inlet unit, the filter water outlet unit, the backwashing water inlet unit, the backwashing water outlet unit and the sewage discharge unit are connected with the filter unit, and the controller controls the filter unit, the filter water inlet unit, the filter water outlet unit, the backwashing water inlet unit, the backwashing water outlet unit and the sewage discharge unit. The number and the layout of the filter units and the number of the filters can be determined according to the size and the shape of a test site, so that the problem that the field installation and the layout of the filters are limited is solved; the back washing of the filtering unit and the replacement of the filter screen and the filter material are independently carried out, the filtering of other filtering units is not influenced, and the continuity of the whole sewage treatment is ensured.
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3:
[发明]
【中文】一种小尺寸轴瓦高效焊接平台 【EN】High-efficient welded platform of small-size axle bush
申请号:
201911395691.9
公开号:CN111015068A 主分类号:B23K37/047
申请人:
【中文】张家港江苏科技大学产业技术研究院【EN】Jiangsu University Of Science And Technology Industrial Technology Research Institute Of
申请日:2019.12.30 公开日:2020.04.17
发明人:
【中文】张德义
;
高进可
;
方海峰
;
范纪华
;
王琪
;
穆开洪
;
李长征
;
戴昕哲
;
徐海浩【EN】Zhang Deyi
;
Gao Jinke
;
Fang Haifeng
;
Fan Jihua
;
Wang Qi
;
Mu Kaihong
;
Li Changzheng
;
Dai Xinzhe
;
Xu Haihao
摘要:【中文】本发明公开了一种小尺寸轴瓦高效焊接平台,包括:支撑架;轴瓦夹持装置,安装在支撑架上,包括第一转盘、多个转动安装在第一转盘上的卡盘、以及用于驱动第一转盘转动的第一驱动模块,多个卡盘成圆周阵列分布在第一转盘上;以及焊接摩刷装置,安装在支撑架上,与轴瓦夹持装置相对设置,包括第二转盘,多个安装在第二转盘靠近卡盘一侧上的焊枪和焊刷,以及用于驱动第二转盘转动、并能带动第二转盘沿第一转盘轴向靠近或远离第一转盘以使得焊枪和焊刷靠近或远离卡盘的第二驱动模块,焊枪和焊刷分别均匀分布在第二转盘的圆周两侧,并与卡盘一一对应设置。采用转盘式焊刷,一次能同时加工多个轴瓦,有利于小尺寸轴瓦的大规模、批量化生产,以满足需求。 【EN】The invention discloses a small-size efficient bearing bush welding platform, which comprises a support frame, a welding rod and a welding rod, wherein the support frame is provided with a plurality of welding holes; the bearing bush clamping device is arranged on the supporting frame and comprises a first rotary table, a plurality of chucks rotationally arranged on the first rotary table and a first driving module used for driving the first rotary table to rotate, wherein the plurality of chucks are distributed on the first rotary table in a circumferential array; and the welding friction brush device is arranged on the support frame and is arranged opposite to the bearing bush clamping device, and comprises a second turntable, a plurality of welding guns and welding brushes which are arranged on one side, close to the chuck, of the second turntable, and a second driving module which is used for driving the second turntable to rotate and can drive the second turntable to be close to or far away from the first turntable along the axial direction of the first turntable so as to enable the welding guns and the welding brushes to be close to or far away from the chuck, and the welding guns and the welding brushes are respectively and uniformly distributed on two sides of the circumference of the second turntable and are arranged in a one-to-one correspondence manner with the. The rotary disc type welding brush is adopted, a plurality of bearing bushes can be simultaneously processed at one time, and large-scale and batch production of small-size bearing bushes is facilitated, so that the requirements are met.
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4:
[发明]
【中文】一种转炉投掷料快补方法 【EN】Converter material throwing fast repairing method
申请号:
202010038938.8
公开号:CN111172350A 主分类号:C21C5/44
申请人:
【中文】山东钢铁股份有限公司【EN】SHANDONG IRON AND STEEL COMPANY Ltd.
申请日:2020.01.14 公开日:2020.05.19
发明人:
【中文】胡滨
;
任科社
;
胡连军
;
张伟
;
杜金科
;
于亮涛
;
高志滨
;
薛志
;
王建峰
;
朱天奇
;
刘奚
;
尚游【EN】Hu Bin
;
Ren Keshe
;
Hu Lianjun
;
Zhang Wei
;
Du Jinke
;
Yu Liangtao
;
Gao Zhibin
;
Xue Zhi
;
Wang Jianfeng
;
Zhu Tianqi
;
Liu Xi
;
Shang You
摘要:【中文】本发明涉及一种转炉投掷料快补方法,主要技术方案为利用袋装补炉料对炉体内衬进行定点补炉,使用该方法进行补炉,节省了补炉时间,减少了补炉料的使用量,同时补炉烧结后的补料不易脱落,稳定性好。 【EN】The invention relates to a converter throwing material quick repairing method, which adopts the main technical scheme that a fixed-point furnace repairing is carried out on a lining of a furnace body by utilizing bagged repairing materials.
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5:
[发明]
【中文】一种转炉开吹助燃方法 【EN】Converter blowing combustion-supporting method
申请号:
202010038106.6
公开号:CN111139331A 主分类号:C21C5/46
申请人:
【中文】山东钢铁股份有限公司【EN】SHANDONG IRON AND STEEL COMPANY Ltd.
申请日:2020.01.14 公开日:2020.05.12
发明人:
【中文】胡滨
;
胡连军
;
王忠刚
;
任科社
;
张伟
;
高志滨
;
于亮涛
;
杜金科
;
薛志
;
朱天奇
;
尚游【EN】Hu Bin
;
Hu Lianjun
;
Wang Zhonggang
;
Ren Keshe
;
Zhang Wei
;
Gao Zhibin
;
Yu Liangtao
;
Du Jinke
;
Xue Zhi
;
Zhu Tianqi
;
Shang You
摘要:【中文】本发明涉及转炉炼钢领域的一种转炉开吹助燃方法,主要通过在打火异常时,添加一定量的焦末助燃,并且在打火正常后,控制氧枪距离及相应氧压完成冶炼过程,本发明涉及的技术方案操作简单,执行方便,使用效果好,可在较短的时间内,避免开吹打火不正常和烟道爆燃现象,较好的保障了设备安全及生产顺行。 【EN】The invention relates to a combustion-supporting method for blowing converter in the field of converter steelmaking, which mainly adds a certain amount of coke breeze to support combustion when the ignition is abnormal, and controls the distance of an oxygen lance and the corresponding oxygen pressure to finish the smelting process after the ignition is normal.
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6:
[发明]
【中文】一种改善转炉终渣泡沫化的方法 【EN】Method for improving foaming of converter final slag
申请号:
202010108030.X
公开号:CN111100964A 主分类号:C21C5/36
申请人:
【中文】山东钢铁股份有限公司【EN】SHANDONG IRON AND STEEL COMPANY Ltd.
申请日:2020.02.21 公开日:2020.05.05
发明人:
【中文】胡滨
;
王忠刚
;
胡连军
;
任科社
;
张伟
;
高志滨
;
杜金科
;
薛志
;
尚游【EN】Hu Bin
;
Wang Zhonggang
;
Hu Lianjun
;
Ren Keshe
;
Zhang Wei
;
Gao Zhibin
;
Du Jinke
;
Xue Zhi
;
Shang You
摘要:【中文】本发明涉及转炉炼钢领域,具体涉及一种改善转炉终渣泡沫化的方法。本发明方法是在出钢过程中,将转炉使用后的废旧探头再次利用,快速平抑泡沫渣,使泡沫渣趋于平稳,然后再辅以炉渣压制能够较好的抑制泡沫渣。本发明操作简单,执行方便,使用效果好,可在较短的时间内,迅速平抑泡沫渣,降低了因泡沫渣进入钢包带来的合金、脱氧剂消耗增加及钢中夹杂物增加等弊端,还可以节约成本,避免浪费。 【EN】The invention relates to the field of converter steelmaking, in particular to a method for improving foaming of converter final slag. In the method, the waste probe used by the converter is reused in the tapping process, so that the foam slag is quickly stabilized, and is stabilized, and then the slag pressing is assisted to better inhibit the foam slag. The invention has simple operation, convenient execution and good use effect, can quickly stabilize the foam slag in a shorter time, reduces the defects of alloy and deoxidizer consumption increase, inclusion increase in steel and the like caused by the foam slag entering the steel ladle, can save the cost and avoid waste.
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