摘要：【中文】本申请公开了同位素富集的乐伐替尼、其药学上可接受的盐形式，以及使用其的治疗方法。具体地，本申请涉及一种式I的同位素富集的化合物或其药学上可接受的盐，其中，R₁～R₁₉独立地选自氢或氘；X_a～X_d独立地选自¹⁶O、¹⁷O或¹⁸O；Y_a和Y_b独立地选自¹²C或¹³C；Z_a～Z_d选自¹⁴N或¹⁵N；条件是R‑基团(R₁～R₁₉)、X‑基团(X_a～X_d)、Y‑基团(Y_a和Y_b)和Z‑基团(Z_a～Z_d)中的至少一个是同位素富集的原子或基团。通过同位素富集来改善药代动力学、药效学、药物代谢和清除途径，进而改善药物治疗疾病的功效和/或范围。此外本申请还涉及包括同位素富集的化合物的组合物以及其在治疗疾病中的用途。 【EN】Isotopically enriched lenvatinib, pharmaceutically acceptable salt forms thereof, and methods of treatment using the same are disclosed. In particular, the application relates to an isotopically enriched compound of formula I or a pharmaceutically acceptable salt thereof, wherein R₁～R₁₉Independently selected from hydrogen or deuterium; x_a～X_dIs independently selected from¹⁶O、¹⁷O or¹⁸O；Y_aAnd Y_bIs independently selected from¹²C or¹³C；Z_a～Z_dIs selected from¹⁴N or¹⁵N; with the proviso that R-group (R)₁～R₁₉) X-radical (X)_a～X_d) Y-group (Y)_aAnd Y_b) And Z-group (Z)_a～Z_d) Is an isotopically enriched atom or group. By the same tokenSite-directed enrichment improves pharmacokinetics, pharmacodynamics, drug metabolism, and clearance pathways, thereby improving the efficacy and/or extent of drug therapy for disease. The application further relates to compositions comprising isotopically enriched compounds and their use in the treatment of disease.

摘要：【中文】本发明涉及化合物3‑((L‑缬氨酰基)氨基)‑1‑丙磺酸的晶型、其制备方法及其用途。 【EN】The present invention relates to a crystalline form of the compound 3- ((L-valyl) amino) -1-propanesulfonic acid, processes for its preparation and its use.

摘要：【中文】本发明公开了鼠李糖乳杆菌(Lactobacillus rhamnosus)ZFM231，保藏编号为：CCTCC NO:M 2019883。该菌株在葡萄糖为碳源的M RS培养基中培养，培养后的粗多糖经DEAE‑52柱层析以及Sephadex G‑100凝胶柱分离纯化后得到四种不同的胞外多糖组分EPS‑0M,EPS‑0.1M,EPS‑0.3M和EPS‑0.5M。本发明鼠李糖乳杆菌胞外多糖及其四个组分具有较强的抗氧化能力；四个组分具有显著的脂肪酶抑制活性，且有较强的降低胆固醇及甘油三酯的效果。通过构建肠道微生物体外发酵模型实验表明各组分均对肠道菌群有较好的调节作用。 【EN】The invention discloses Lactobacillus rhamnosus (Lactobacillus rhamnosus) ZFM231, which has a preservation number of: CCTCC NO: M2019883. The strain is cultured in an M RS culture medium with glucose as a carbon source, and four different extracellular polysaccharide components of EPS-0M, EPS-0.1M, EPS-0.3M and EPS-0.5M are obtained after the cultured crude polysaccharide is separated and purified by DEAE-52 column chromatography and Sephadex G-100 gel column. The lactobacillus rhamnosus exopolysaccharide and the four components thereof have stronger antioxidant capacity; the four components have obvious lipase inhibition activity and stronger effect of reducing cholesterol and triglyceride. Experiments for constructing an in-vitro fermentation model of the intestinal microorganisms show that all the components have better regulation effect on the intestinal flora.

摘要：【中文】本发明公开了智能化展示信息模型系统，包括展示一体计算机、底座、逐级转动调节组件、高度调节组件、轴承、云储存平台、PLC控制器、信息上传模块、WIFI传输模块、信息调用模块、储存器、信息互联模块、信息交互模块、智能管理模块和显示模块，所述展示一体计算机的底端外壁上设置有底座，所述底座的底端内壁上设置有逐级转动调节组件；该发明，具体是展馆智能化展览用的计算机，以技术创新增强科普宣教手段，优化游客体验，提高展馆管理水平，实现展馆的智能化管理和运行，从传统服务业向现代服务业升级，其中逐级转动调节组件和高度调节组件的设置，能实现展览用计算机浏览方向和高度的逐级调节，利于后期人们浏览。 【EN】The invention discloses an intelligent information display model system which comprises a display integrated computer, a base, a step-by-step rotation adjusting assembly, a height adjusting assembly, a bearing, a cloud storage platform, a PLC (programmable logic controller), an information uploading module, a WIFI (wireless fidelity) transmission module, an information calling module, a storage, an information interconnection module, an information interaction module, an intelligent management module and a display module, wherein the base is arranged on the outer wall of the bottom end of the display integrated computer, and the step-by-step rotation adjusting assembly is arranged on the inner wall of the bottom end of the base; the invention relates to a computer for intelligent exhibition of an exhibition hall, which enhances science popularization and education means by technical innovation, optimizes tourist experience, improves the management level of the exhibition hall, realizes intelligent management and operation of the exhibition hall, and is upgraded from the traditional service industry to the modern service industry, wherein the arrangement of an adjusting component and a height adjusting component is rotated step by step, so that the browsing direction and the height of the computer for exhibition can be adjusted step by step, and the computer is beneficial to browsing of people at the later stage.

摘要：【中文】本发明提供式(I)化合物及其药学上可接受的盐和酯，以及其药物组合物，所述化合物及其药物组合物在用于治疗和/或预防CD73相关的疾病、失调和病症(包括癌症相关和免疫相关失调)的用途。 【EN】The present invention provides compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, as well as pharmaceutical compositions thereof, the use of the compounds and pharmaceutical compositions thereof for the treatment and/or prevention of CD 73-related diseases, disorders, and conditions, including cancer-related and immune-related disorders.

摘要：【中文】本发明公开了一种基于地下水水文地质试验的数值模拟检测方法，所述方法包括如下步骤：步骤1：采集模拟区场地实际抽水试验中的水位变化数据；步骤2：基于所述水位变化数据，建立地下水流概念模型；步骤3：基于地下水流概念模型，正演模拟并初步确定缺陷情形；以及步骤4：根据所述缺陷情形进行反演计算以得出渗透系数，调整所述渗透系数，并且基于所述渗透系数来定量评估垂直防渗墙的完整性。该方法既可以定量检测垂直防渗墙的整体防渗性能，又能够精确模拟分析垂直防渗墙结构缺陷处的具体位置及规模大小等，在很大程度上弥补了垂直反射法、弹性波CT法等检测技术的不足之处，对于完善垂直防渗墙质量检测体系至关重要。 【EN】The invention discloses a numerical simulation detection method based on a groundwater hydrogeological test, which comprises the following steps: step 1: collecting water level change data in an actual pumping test of a simulation area site; step 2: establishing an underground water flow conceptual model based on the water level change data; and step 3: based on the underground water flow conceptual model, forward modeling and preliminarily determining the defect situation; and step 4: performing an inversion calculation based on the defect condition to derive a permeability coefficient, adjusting the permeability coefficient, and quantitatively evaluating the integrity of the vertical cut-off wall based on the permeability coefficient. The method can quantitatively detect the whole anti-seepage performance of the vertical anti-seepage wall, can accurately simulate and analyze the specific position, the scale and the like of the structural defect of the vertical anti-seepage wall, makes up for the defects of detection technologies such as a vertical reflection method, an elastic wave CT method and the like to a great extent, and is vital to the improvement of a quality detection system of the vertical anti-seepage wall.