摘要：【中文】本发明提供一种组织工程皮肤支架材料，所述组织工程皮肤支架材料由透明质酸支架和纳米纤维膜组成；所述透明质酸支架由超氧化物歧化酶脂质体负载于透明质酸多孔支架上制得；所述纳米纤维膜由壳聚糖/角蛋白混合溶液制得。本发明还提供组织工程皮肤支架材料的制备方法，采用静电纺丝技术与冷冻干燥技术结合的方法制备的双层皮肤支架材料，解决了皮肤支架材料的生物相容性差和孔径大小不合适的问题以及创面皮肤受有害代谢物影响的问题，且制备方法简单，绿色环保。 【EN】The invention provides a tissue engineering skin scaffold material, which consists of a hyaluronic acid scaffold and a nanofiber membrane; the hyaluronic acid scaffold is prepared by loading superoxide dismutase liposome on a hyaluronic acid porous scaffold; the nanofiber membrane is prepared from a chitosan/keratin mixed solution. The invention also provides a preparation method of the tissue engineering skin scaffold material, the double-layer skin scaffold material prepared by adopting the method of combining the electrostatic spinning technology and the freeze drying technology solves the problems of poor biocompatibility and improper pore size of the skin scaffold material and the problem that wound skin is influenced by harmful metabolites, and the preparation method is simple, green and environment-friendly.

摘要：【中文】本发明公开了一种抗菌型胶原基骨修复材料，包括氧化锌/羟基磷灰石晶须、Ⅰ型胶原、聚乙烯醇、交联剂构成的骨修复材料主体以及氧化石墨烯、聚多巴胺、掺杂磺基水杨酸的聚吡咯自组装层和固载于自组装层的骨形态发生蛋白‑2。本发明材料表面及内部均具有良好的抗菌功效，能够最大程度避免骨移植过程中的炎症、感染，所用原料均无毒无害，具有良好的生物相容性，材料的降解速度与骨缺损修复速度相对一致，通过在骨修复材料表面自组装聚吡咯‑聚多巴胺涂层，能够牢固负载骨形态发生蛋白‑2和稳定释放，提高了骨形态发生蛋白‑2的利用率，同时也极大地避免骨形态发生蛋白‑2浓度过高引发的并发症。 【EN】The invention discloses an antibacterial collagen-based bone repair material which comprises a bone repair material main body, a graphene oxide, polydopamine, a polypyrrole self-assembly layer doped with sulfosalicylic acid and bone morphogenetic protein-2 fixedly carried in the self-assembly layer, wherein the bone repair material main body is composed of zinc oxide/hydroxyapatite whiskers, type I collagen, polyvinyl alcohol and a cross-linking agent. The surface and the interior of the material have good antibacterial effect, inflammation and infection in the bone grafting process can be avoided to the maximum extent, the used raw materials are nontoxic and harmless, the material has good biocompatibility, the degradation speed of the material is relatively consistent with the bone defect repair speed, the polypyrrole-polydopamine coating is self-assembled on the surface of the bone repair material, the bone morphogenetic protein-2 can be firmly loaded and stably released, the utilization rate of the bone morphogenetic protein-2 is improved, and complications caused by overhigh concentration of the bone morphogenetic protein-2 are greatly avoided.

摘要：【中文】本发明公开了一种含蛋白质胶原基骨修复材料，包括介孔羟基磷灰石、改性麦饭石、聚乳酸乙醇酸共聚物、Ⅰ型胶原构成的骨修复材料主体以及氧化石墨烯‑聚吡咯自组装层和固载于自组装层的骨形态发生蛋白‑2。本发明所用原料均无毒无害，具有良好的生物相容性，机械性能优异，材料的降解速度与骨缺损修复速度相对一致，具有较强的成骨活性，形成了骨形态发生蛋白‑2可控释放体系，不会发生突释或无法释放的情况，提高了骨形态发生蛋白‑2的利用率，同时也极大地避免骨形态发生蛋白‑2浓度过高引发的并发症。 【EN】The invention discloses a collagen-based bone repair material containing protein, which comprises a bone repair material main body consisting of mesoporous hydroxyapatite, modified medical stone, polylactic acid-glycolic acid copolymer and collagen I, a graphene oxide-polypyrrole self-assembly layer and bone morphogenetic protein-2 immobilized on the self-assembly layer. The raw materials used in the invention are nontoxic and harmless, have good biocompatibility and excellent mechanical property, the degradation speed of the materials is relatively consistent with the bone defect repair speed, and the materials have strong osteogenic activity, form a bone morphogenetic protein-2 controllable release system, do not generate the condition of burst release or incapability of release, improve the utilization rate of the bone morphogenetic protein-2, and simultaneously greatly avoid complications caused by overhigh concentration of the bone morphogenetic protein-2.

摘要：【中文】本发明公开了一种抗感染组织工程皮肤支架，支架为上下双层结构，层间通过戊二醛交联作用结合在一起，具有良好的机械强度。上层表皮支架聚己内酯‑聚乙二醇‑聚己内酯/纳米银/壳聚糖纳米纱层中纤维内部的纳米银与纤维表面的壳聚糖协同发挥抗菌功效，下层真皮支架丝素/透明质酸纤维中均匀分布有乙酸锌，能够抑制细菌聚集，发挥抗感染功效；下层为纳米纤维束编织支架，纤维束支架的结构、孔径大小及孔隙率可以通过编制自由调节，能够制备得到纤维束有序规则排列、孔径平均值与细胞尺寸接近的支架，使细胞能够进入，并引导组织定向生长。 【EN】The invention discloses an anti-infection tissue engineering skin scaffold, which is of an upper-lower double-layer structure, and layers are combined together through glutaraldehyde crosslinking, so that the scaffold has good mechanical strength. The nano silver inside the fiber in the upper-layer dermal scaffold polycaprolactone-polyethylene glycol-polycaprolactone/nano silver/chitosan nano yarn layer and the chitosan on the surface of the fiber cooperatively play an antibacterial role, and the zinc acetate is uniformly distributed in the lower-layer dermal scaffold fibroin/hyaluronic acid fiber, so that the bacterial aggregation can be inhibited, and the anti-infection function is played; the lower layer is a nano fiber bundle woven support, the structure, the pore size and the porosity of the fiber bundle support can be freely adjusted through weaving, and the support with orderly and regular arrangement of fiber bundles and the average pore size close to the cell size can be prepared, so that cells can enter and direct the tissue to grow directionally.

摘要：【中文】本发明提供一种抗炎抗菌复合皮肤支架材料，所述复合皮肤支架材料由透明质酸真皮层支架和聚己内酯表皮层支架组成；所述复合皮肤支架上负载有海藻酸钠凝胶微球，所述海藻酸钠凝胶微球包含有超氧化物歧化酶及没食子酸；所述透明质酸支架上络合有铜离子、锌离子；本发明采用两次冷冻干燥技术将透明质酸支架和聚己内酯支架结合得到复合皮肤支架材料，解决了创面皮肤易感染、发炎及产生瘢痕问题以及支架材料粘附性弱的问题，并且该皮肤支架材料不仅具有良好的生物相容性和粘附性，且机械性能好，无机体排异性，均可生物降解，降解的产物对生物组织没有毒性也没有异常反应，制备方法简单，绿色环保。 【EN】The invention provides an anti-inflammatory and antibacterial composite skin scaffold material, which consists of a hyaluronic acid dermal layer scaffold and a polycaprolactone epidermal layer scaffold; the composite skin stent is loaded with sodium alginate gel microspheres, and the sodium alginate gel microspheres contain superoxide dismutase and gallic acid; copper ions and zinc ions are complexed on the hyaluronic acid stent; the hyaluronic acid scaffold and the polycaprolactone scaffold are combined by adopting a freeze drying technology twice to obtain the composite skin scaffold material, so that the problems of wound skin infection, inflammation and scar generation and weak scaffold material adhesion are solved, the skin scaffold material has good biocompatibility and adhesion, good mechanical property and inorganic body rejection, and can be biodegraded, the degraded product has no toxicity or abnormal reaction to biological tissues, the preparation method is simple, and the composite skin scaffold material is green and environment-friendly.

摘要：【中文】本发明公开了一种可完全降解组织工程皮肤支架材料，包括细菌纤维素/壳聚糖纳米纤维层和大孔径阵列微米纤维支架两部分，细菌纤维素/壳聚糖纳米纤维层为上层，大孔径阵列微米纤维支架上方为下层，层间通过戊二醛交联结合；所述细菌纤维素/壳聚糖纳米纤维层由木葡糖酸醋杆菌原位合成，表面固定有纤维素酶；所述大孔径阵列微米纤维支架为静电纺乳酸/透明质酸/丝素微纳米纤维有序排列的支架，表面修饰有聚乳酸‑羟基乙酸生长因子缓释微球。本发明所用原料均无毒无害，纤维性质稳定，具有良好的生物相容性，能够在体内完全降解，下层支架的孔隙直径与细胞尺寸接近，使细胞能够进入，还能稳定释放生长因子，有利于皮肤组织再生。 【EN】The invention discloses a completely degradable tissue engineering skin scaffold material, which comprises a bacterial cellulose/chitosan nano fiber layer and a large-aperture array micrometer fiber scaffold, wherein the bacterial cellulose/chitosan nano fiber layer is an upper layer, a lower layer is arranged above the large-aperture array micrometer fiber scaffold, and the layers are combined by glutaraldehyde through crosslinking; the bacterial cellulose/chitosan nanofiber layer is synthesized in situ by gluconacetobacter xylinus, and cellulase is fixed on the surface of the bacterial cellulose/chitosan nanofiber layer; the large-aperture array micro-fiber scaffold is a scaffold with orderly arranged electrospun lactic acid/hyaluronic acid/fibroin micro-nano fibers, and polylactic acid-glycolic acid growth factor sustained-release microspheres are modified on the surface. The raw materials used in the invention are nontoxic and harmless, the fiber property is stable, the biocompatibility is good, the fiber can be completely degraded in vivo, the pore diameter of the lower layer bracket is close to the cell size, the cell can enter, the growth factor can be stably released, and the regeneration of skin tissues is facilitated.

摘要：【中文】本发明提供一种可吸收防黏连敷料，所述可吸收防黏连敷料从贴近皮肤侧起依次为疏水层、亲水层及保护层，所述疏水层为负载微球的聚己内酯/壳聚糖多孔薄膜，所述亲水层的材料为透明质酸、明胶、海藻酸钠或角蛋白中的一种或多种，所述保护层为蛋壳膜与改性聚氨酯薄膜复合而成，本发明还提供了可吸收防黏连敷料的制备方法，制得的可吸收防黏连敷料可降解吸收，不需频繁更换，保持了利于创口修复的湿润环境，力学性能优，抗菌作用强，可促进药物的单向吸收，提高敷料的利用率，且更换敷料时也不会出现黏连创面的问题，防止了二次损伤。 【EN】The invention provides an absorbable anti-adhesion dressing which sequentially comprises a hydrophobic layer, a hydrophilic layer and a protective layer from the side close to the skin, wherein the hydrophobic layer is a polycaprolactone/chitosan porous film loaded with microspheres, the hydrophilic layer is made of one or more of hyaluronic acid, gelatin, sodium alginate or keratin, and the protective layer is formed by compounding an eggshell film and a modified polyurethane film.

摘要：【中文】本发明提供一种杀菌抗炎创面修复敷料，所述杀菌抗炎创面修复敷料由背衬层、复合抗菌层及疏水贴肤层组成，所述背衬层为生物可降解高分子材料制成的薄膜；所述复合抗菌层是以原花青素、尿囊素负载于疏水多孔薄膜上，并由缓冲性纳米纤维层包裹制成，所述缓冲性纳米纤维层由蜂蜜、柠檬酸及亲水性高分子材料制成，所述疏水贴肤层由疏水性材料聚乳酸、聚己内酯中的一种与壳聚糖混合制成；本发明还提供了杀菌抗炎创面修复敷料的制备方法，且本发明制备的杀菌抗炎创面修复敷料不仅可体内降解吸收，抗炎抗菌，同时确保了所含原花青素、尿囊素的稳定性及缓释性，为原花青素及尿囊素的应用拓展了范围。 【EN】The invention provides a sterilization and anti-inflammation wound repair dressing which consists of a back lining layer, a composite antibacterial layer and a hydrophobic skin-sticking layer, wherein the back lining layer is a thin film made of biodegradable high polymer materials; the composite antibacterial layer is prepared by loading procyanidine and allantoin on a hydrophobic porous film and wrapping a buffering nanofiber layer, wherein the buffering nanofiber layer is prepared from honey, citric acid and a hydrophilic high polymer material, and the hydrophobic skin-sticking layer is prepared by mixing one of a hydrophobic material polylactic acid and polycaprolactone with chitosan; the invention also provides a preparation method of the sterilizing and anti-inflammatory wound repair dressing, and the sterilizing and anti-inflammatory wound repair dressing prepared by the invention not only can be degraded and absorbed in vivo, is anti-inflammatory and antibacterial, but also ensures the stability and slow release of the contained procyanidin and allantoin, and expands the range of application of the procyanidin and the allantoin.

摘要：【中文】本发明公开了一种直流落地点近区电网一次调频分区协同控制的方法及系统，所述方法包括以下步骤：实时监测特高压直流线路的运行状态信号，并发送至直流落点近区参与一次调频协同控制的单元机组；对直流落地点近区进行一次调频补偿区域划分；生成直流落点近区单元机组一次调频控制指令，进行分区控制。本发明有效提升了电网的一次调频能力，缩短了电网频率恢复时间，保障了电网的安全稳定运行。 【EN】The invention discloses a method and a system for primary frequency modulation zone cooperative control of a direct current floor point near-zone power grid, wherein the method comprises the following steps: monitoring an operation state signal of an extra-high voltage direct current line in real time, and sending the operation state signal to a unit set participating in primary frequency modulation cooperative control in a direct current drop point near area; performing primary frequency modulation compensation area division on a near area of a direct current landing place; and generating a primary frequency modulation control instruction of the direct-current drop point near-zone unit set, and performing zone control. The invention effectively improves the primary frequency modulation capability of the power grid, shortens the frequency recovery time of the power grid and ensures the safe and stable operation of the power grid.

摘要：【中文】本发明提供一种网源协调互动的AGC运行机组负荷变化速率优化方法和系统，通过实时采集机组运行参数，确定机组调节性能指标和安全指标，根据所述指标计算机组的紧急调用允许/禁止信号和紧急负荷调节速率信号；电力调度控制中心接收所述信号，根据当前全网功率调节需求，输出紧急调用投入/退出信号；切换模块根据机组自身的紧急调用允许/禁止信号和调度下发的紧急调用投入/退出信号，在正常负荷调节速率和紧急负荷调节速率进行切换，输出最终的机组负荷变化速率信号。本发明考虑电网当前调节需求的紧迫程度和机组的真实调节性能，动态对机组负荷调节速率进行管理，实现了网源协调控制，提高了电网频率的稳定性。 【EN】The invention provides a method and a system for optimizing the load change rate of an AGC (automatic gain control) running unit with network source coordination interaction, wherein the method comprises the steps of determining a unit regulation performance index and a safety index by acquiring unit running parameters in real time, and calculating an emergency call permission/prohibition signal and an emergency load regulation rate signal of the unit according to the indexes; the power dispatching control center receives the signal and outputs an emergency call input/exit signal according to the current power regulation requirement of the whole network; and the switching module switches between the normal load regulation rate and the emergency load regulation rate according to the emergency call enable/disable signal of the unit and the emergency call input/exit signal issued by scheduling, and outputs a final unit load change rate signal. The invention dynamically manages the load regulation rate of the unit by considering the urgency degree of the current regulation requirement of the power grid and the real regulation performance of the unit, realizes the network source coordination control and improves the stability of the power grid frequency.