摘要：【中文】本发明公开了一种药物组合在制备治疗细菌感染性疾病合并乙型肝炎的药物中的应用，所述药物组合包含哌拉西林或其盐以及舒巴坦或其盐。哌拉西林和舒巴坦的比例可以为2:1或4:1。本发明提供的药物组合在治疗细菌感染特别是耐药细菌感染的同时，可明显增强乙肝患者的肝功能，减轻肝损伤，对抗乙肝病毒感染，并增强抗乙肝病毒药物的疗效。 【EN】The invention discloses application of a pharmaceutical composition in preparing a medicament for treating bacterial infectious diseases combined with hepatitis B, wherein the pharmaceutical composition comprises piperacillin or salt thereof and sulbactam or salt thereof. The ratio of piperacillin and sulbactam may be 2:1 or 4: 1. The medicine composition provided by the invention can obviously enhance the liver function of hepatitis B patients, relieve liver injury, resist hepatitis B virus infection and enhance the curative effect of anti-hepatitis B virus medicines while treating bacterial infection, particularly drug-resistant bacterial infection.