当前查询到11条专利与查询词 "Jiang Shengfu"相关,搜索用时0.3437046秒!排序方式:
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申请号:201911160129.8 公开号:CN110862448A 主分类号:C07K14/605
申请人:【中文】浙江大学【EN】ZHEJIANG University 申请日:2019.11.21 公开日:2020.03.06
摘要:【中文】本发明公开了一种两性离子多肽修饰的GLP‑1衍生物及其制备方法和应用。它是在GLP‑1衍生物的反应位点连接有两性离子多肽。特别的,在GLP‑1衍生物中的点击反应位点与两性离子多肽连接,两性离子多肽含有聚(L‑谷氨酰基‑L‑赖氨酸),聚(L‑谷氨酰基‑L‑赖氨酸)含有与所述点击反应位点连接的反应基团。本发明两性离子多肽修饰的GLP‑1衍生物可用于制备Ⅱ型糖尿病人长效控血糖药物,相比已上市的GLP‑1类药物,具有更平稳的体内缓释,更优秀的血液长循环能力,更低的组织排异性,低免疫原性,优秀的组织相容性、体内酶降解和正常代谢能力,不易引发低血糖和不良肠胃反应,可避免注射位置结节等特点。 【EN】The invention discloses a GLP-1 derivative modified by zwitterionic polypeptide and a preparation method and application thereof. It is formed by connecting zwitter-ion polypeptide at the reaction site of GLP-1 derivative. In particular, the click reaction site in the GLP-1 derivative is linked to a zwitterionic polypeptide comprising poly (L-glutamyl-L-lysine) which comprises a reactive group linked to said click reaction site. Compared with the GLP-1 medicines on the market, the GLP-1 derivative modified by the zwitterionic polypeptide can be used for preparing the long-acting blood sugar control medicines for the type II diabetics, and has the characteristics of more stable in-vivo slow release, more excellent blood long circulation capability, lower tissue rejection, low immunogenicity, excellent histocompatibility, in-vivo enzyme degradation and normal metabolic capability, difficulty in causing hypoglycemia and adverse gastrointestinal reaction, avoidance of injection position nodules and the like.
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申请号:201911187775.3 公开号:CN110861512A 主分类号:B60L53/14
摘要:【中文】本发明提供了一种充电控制装置、充电机和车辆,该装置包括信号处理电路、控制器、定时唤醒模块和电源模块;该信号处理电路外接有充电设备;该信号处理电路用于,当从充电设备接收到控制导引信号时,将控制导引信号转换为单个上升沿的输出信号;该控制器用于,当从信号处理电路接收到该输出信号时,判断当前充电模式是否为预约充电模式,如果是,控制充电控制装置进入休眠状态;该定时唤醒模块用于,在预约充电模式下,当预设的充电时间到达时,唤醒该充电控制装置,以向上述充电设备发起充电握手请求;该电源模块用于给上述信号处理电路、控制器和定时唤醒模块提供电源。本发明可以降低预约充电等待过程中充电控制装置的低压功耗,更加节能。 【EN】The invention provides a charging control device, a charger and a vehicle, wherein the device comprises a signal processing circuit, a controller, a timing awakening module and a power supply module; the signal processing circuit is externally connected with a charging device; the signal processing circuit is used for converting the control pilot signal into an output signal of a single rising edge when the control pilot signal is received from the charging equipment; the controller is used for judging whether the current charging mode is the reserved charging mode or not when the output signal is received from the signal processing circuit, and controlling the charging control device to enter a dormant state if the current charging mode is the reserved charging mode; the timing awakening module is used for awakening the charging control device to initiate a charging handshake request to the charging equipment when preset charging time is reached in a reserved charging mode; the power module is used for providing power for the signal processing circuit, the controller and the timing wake-up module. The invention can reduce the low-voltage power consumption of the charging control device in the process of reserving charging waiting and save more energy.
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申请号:201911265199.X 公开号:CN110920454A 主分类号:B60L53/60
摘要:【中文】本发明提供了一种充电过压监控系统,该系统包括依次相连的充电控制模块、过压监控模块和运行状态监控模块;该充电控制模块,用于响应指定充电模式下的充电请求,控制相应的充电设备对动力电池进行充电;该过压监控模块,用于监控该充电设备输出的实时充电参数值是否满足预设充电要求,如果否,执行预设的充电过压保护措施;该运行状态监控模块,用于监控该充电过压监控系统的运行状态是否满足预设运行要求,如果否,执行预设的系统安全措施。本发明通过监控充电过程中的实时充电参数值,可以有效预防过压情况的发生;并通过对监控系统自身所运行的硬件环境,以及监控程序的运行状态进行监控,可以进一步提高动力电池在充电过程中的安全性。 【EN】The invention provides a charging overvoltage monitoring system, which comprises a charging control module, an overvoltage monitoring module and an operation state monitoring module which are sequentially connected; the charging control module is used for responding to a charging request in a designated charging mode and controlling corresponding charging equipment to charge the power battery; the overvoltage monitoring module is used for monitoring whether a real-time charging parameter value output by the charging equipment meets a preset charging requirement, and if not, executing a preset charging overvoltage protection measure; the running state monitoring module is used for monitoring whether the running state of the charging overvoltage monitoring system meets the preset running requirement or not, and if not, executing the preset system safety measure. According to the invention, the occurrence of overvoltage can be effectively prevented by monitoring the real-time charging parameter value in the charging process; and the safety of the power battery in the charging process can be further improved by monitoring the hardware environment of the monitoring system and the running state of the monitoring program.
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申请号:201910970593.7 公开号:CN110855082A 主分类号:H02K9/19
摘要:【中文】本发明公开了一种水冷管,它包括管体、连接部,所述管体下部呈流线型,其两端有贯穿的风孔,风孔内壁和管体外部均涂有纳米级不沾涂料,在管体接近连接部的侧面,装有微型电机,其轴端穿过轴封结构带动伸入管体内部的扇叶进行搅流,所述连接部有内丝口,通过直通等管路连接电动汽车的电机水冷外壳,管体上部有固定结构可将管体固定于车辆底盘或后备箱侧面,能利用车辆运行时产生的高速气流迅速冷却内部的冷却水,并由扇叶将冷却水带入电机的水冷外壳,大大提高了冷却效率,从而提高电机效率和寿命。 【EN】The invention discloses a water-cooled tube, which comprises a tube body and a connecting part, wherein the lower part of the tube body is streamline, two ends of the tube body are provided with air holes which penetrate through the tube body, the inner wall of each air hole and the outer part of the tube body are coated with nanoscale non-stick coating, a micro motor is arranged on the side surface of the tube body close to the connecting part, the shaft end of the micro motor penetrates through a shaft seal structure to drive a fan blade which extends into the tube body to stir, the connecting part is provided with an inner thread opening, the connecting part is connected with a motor water-cooled shell of an electric automobile through a straight-through pipeline and the like, the tube body can be fixed on the side surface of a chassis or a trunk of the automobile by a fixing structure on the upper part of the tube body, the cooling water in the tube body can be.
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申请号:201910970594.1 公开号:CN110843504A 主分类号:B60K11/02
摘要:【中文】本发明公开了一种电机水冷外壳,它包括壳体、水冷管、水冷装置;所述水冷管包括管体、连接部,所述水冷装置包括管道、冷却液、水泵;所述管道连接壳体;所述管体下部呈流线型,其两端有贯穿的风孔,风孔内壁和管体外部均涂有纳米级不沾涂料,在管体接近连接部的侧面,装有微型电机,其轴端穿过轴封结构带动伸入管体内部的扇叶进行搅流,所述连接部有内丝口,通过三通管路连接管道,管体上部有固定结构可将管体固定于车辆底盘或后备箱侧面,能利用车辆运行时产生的高速气流迅速冷却内部的冷却水,并由扇叶将冷却水带入管道并经过水冷外壳,大大提高了冷却效率,从而提高电机效率和寿命。 【EN】The invention discloses a water-cooling shell of a motor, which comprises a shell, a water-cooling pipe and a water-cooling device, wherein the shell is provided with a water-cooling pipe; the water cooling pipe comprises a pipe body and a connecting part, and the water cooling device comprises a pipeline, cooling liquid and a water pump; the pipeline is connected with the shell; the lower part of the tube body is streamline, the two ends of the tube body are provided with air holes which penetrate through the air holes, the inner wall of each air hole and the outer part of the tube body are coated with nanoscale non-stick coating, the side face of the tube body, which is close to the connecting part, is provided with a micro motor, the shaft end of the micro motor penetrates through a shaft seal structure to drive a fan blade which stretches into the tube body to stir, the connecting part is provided with an inner screw hole, the tube body is fixed on the side face of a vehicle chassis or a trunk through a three-way pipeline connecting pipeline, the upper part of the tube body is provided with a fixing structure, the cooling water in the tube body can be rapidly cooled by utilizing high-speed airflow generated during vehicle operation, the.
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申请号:201910970622.X 公开号:CN110855060A 主分类号:H02K5/20
摘要:【中文】本发明公开了一种水冷永磁电机,它包括永磁电机、水冷外壳;所述水冷外壳装于所述永磁电机外;水冷外壳包括:壳体、水冷管、水冷装置;水冷管包括管体、连接部,水冷装置包括管道、水泵;管道连接壳体;管体下部呈流线型,其两端有贯穿的风孔,风孔内壁和管体外部均涂有纳米级不沾涂料,在管体接近连接部的侧面,装有微型电机,其轴端穿过轴封结构带动伸入管体内部的扇叶进行搅流,所述连接部有内丝口,通过三通管路连接管道,管体上部有固定结构可将管体固定于车辆底盘或后备箱侧面,能利用车辆运行时产生的高速气流迅速冷却内部的冷却水,并由扇叶将冷却水带入管道并经过水冷外壳,大大提高了冷却效率,从而提高电机效率和寿命。 【EN】The invention discloses a water-cooling permanent magnet motor, which comprises a permanent magnet motor and a water-cooling shell; the water-cooling shell is arranged outside the permanent magnet motor; the water-cooled housing includes: the device comprises a shell, a water-cooling pipe and a water-cooling device; the water cooling pipe comprises a pipe body and a connecting part, and the water cooling device comprises a pipeline and a water pump; the pipeline is connected with the shell; the lower part of the tube body is streamline, the two ends of the tube body are provided with air holes which penetrate through the air holes, the inner wall of the air hole and the outer part of the tube body are coated with nanoscale non-stick coating, the side face of the tube body, which is close to the connecting part, is provided with a micro motor, the shaft end of the micro motor penetrates through a shaft seal structure to drive a fan blade which extends into the tube body to stir, the connecting part is provided with an internal thread, the tube body is fixed on the side face of a vehicle chassis or a trunk through a tee pipeline connecting pipeline, the upper part of the tube body is provided with a fixing structure, the cooling water in the tube body can be rapidly cooled by utilizing high-speed airflow generated during the running of a vehicle.
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申请号:201911227378.4 公开号:CN110865216A 主分类号:G01R1/28
摘要:【中文】一种±800kV输变电主设备空载试验用陷波装置,涉及电气试验设备技术领域,其结构为:由3次谐波滤波器和5次谐波滤波器并联组成;3次谐波滤波器和5次谐波滤波器均由电容器组和电抗器串联组成。本发明的有益效果在于:本发明的使用,电压波形校正因素d的绝对值和电压波形畸变率THD均会大幅度减小,能够满足标准要求使得电压波形校正因素d小于等于±3%,3次谐波滤波器和5次谐波滤波器并联使用,能够很明显的减少试验电源的容量,对于现场试验有很大的辅助作用。 【EN】The utility model provides a +/-800 kV power transmission and transformation main equipment is trapped wave device for no-load test, relates to electrical test equipment technical field, and its structure is: the filter is formed by connecting a 3-order harmonic filter and a 5-order harmonic filter in parallel; the 3 rd harmonic filter and the 5 th harmonic filter are both formed by connecting a capacitor bank and a reactor in series. The invention has the beneficial effects that: when the voltage waveform correction factor d is used, the absolute value of the voltage waveform correction factor d and the voltage waveform distortion rate THD are both greatly reduced, the standard requirement can be met, the voltage waveform correction factor d is less than or equal to +/-3%, the 3-order harmonic filter and the 5-order harmonic filter are used in parallel, the capacity of a test power supply can be obviously reduced, and the auxiliary effect on a field test is realized.
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申请号:201911175969.1 公开号:CN110871144A 主分类号:B03D1/008
摘要:【中文】本发明公开了一种基于煤焦油/沥青提取物的复合煤泥浮选药剂及其制备方法,所述浮选药剂由下述重量份的物质组成:非极性烃类油10‑85份,煤焦油/沥青提取物90‑10份,聚乙二醇0.1‑2份,丙三醇0.1‑1份,司盘0.1‑2份。其制备方法是:将煤焦油/沥青在200‑1050℃下在无氧或惰性气体气氛条件下热解,回收其热解溢出的产物,经过冷凝处理后,将这些产物与非极性烃类油、聚乙二醇、丙三醇和司盘按比例搅拌、混匀后,作为煤泥浮选药剂。本发明公开的煤泥浮选药剂,可以大幅提高煤泥浮选精煤中可燃体回收率,改善浮选效果。 【EN】The invention discloses a composite coal slime flotation reagent based on a coal tar/asphalt extract and a preparation method thereof, wherein the flotation reagent consists of the following substances in parts by weight: 10-85 parts of nonpolar hydrocarbon oil, 90-10 parts of coal tar/asphalt extract, 0.1-2 parts of polyethylene glycol, 0.1-1 part of glycerol and 0.1-2 parts of span. The preparation method comprises the following steps: pyrolyzing coal tar/asphalt at 200-1050 ℃ in an oxygen-free or inert gas atmosphere, recovering products overflowing from pyrolysis, and after condensation treatment, stirring and uniformly mixing the products with nonpolar hydrocarbon oil, polyethylene glycol, glycerol and span in proportion to obtain the coal slime flotation reagent. The coal slime flotation reagent disclosed by the invention can greatly improve the recovery rate of combustible substances in coal slime flotation clean coal and improve the flotation effect.
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申请号:201911174438.0 公开号:CN110898999A 主分类号:B03D1/016
摘要:【中文】本发明公开了一种煤焦油基煤泥浮选药剂,所述浮选药剂由下述重量份的物质组成:非极性烃类油10‑90份,煤焦油10‑85份,失水山梨醇脂肪酸酯0.5‑2份,聚乙二醇0.5‑2份,乙酸丙酯0.5‑1份。上述物质混合后经搅拌、加热、再搅拌,如此循环1‑10次后,静置0.5‑48小时获取上层稀液,制得煤泥浮选药剂。本发明通过将非极性烃类油与煤焦油混合,可以大幅提高煤泥中可燃体回收率,改善浮选效果。 【EN】The invention discloses a coal tar-based coal slime flotation reagent which comprises the following substances in parts by weight: 10-90 parts of nonpolar hydrocarbon oil, 10-85 parts of coal tar, 0.5-2 parts of sorbitan fatty acid ester, 0.5-2 parts of polyethylene glycol and 0.5-1 part of propyl acetate. The above-mentioned materials are mixed, stirred, heated and stirred again, and after the above-mentioned processes are circulated for 1-10 times, it is stood still for 0.5-48 hr to obtain upper layer dilute liquor so as to obtain the invented coal slime flotation agent. According to the invention, the nonpolar hydrocarbon oil and the coal tar are mixed, so that the recovery rate of combustible bodies in the coal slime can be greatly improved, and the flotation effect is improved.
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