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申请号:201911366970.2 公开号:CN111000839A 主分类号:A61K31/198
申请人:【中文】广州医科大学【EN】GUANGZHOU MEDICAL University 申请日:2019.12.26 公开日:2020.04.14
摘要:【中文】本发明属于免疫治疗技术领域,首先发现二甲基精氨酸能够有效抑制T、B细胞的体外增殖,在此发现下,研究了ADMA和SDMA体内抑制T、B细胞增殖的机制,研究发现ADMA和SDMA诱导线粒体ROS生成是通过激活AGXT2酶,通过该酶它们被转化为新物质二甲基胍戊酸(DMGV)。因此ADMA、SDMA、DMGV可有效抑制T、B细胞增殖;另外,ADMA被二甲胺水解酶(DDAH)转化为L‑瓜氨酸,因此可以减少进入线粒体被转化为DMGV并发挥作用的ADMA的量,特异性DDAH抑制剂PD404182和ADMA一样,也可以抑制T细胞增殖。因此,二甲基精氨酸及其衍生物和,特异性抑制二甲基精氨酸被降解的物质有望通过抑制T、B细胞的异常增殖为治疗T、B细胞介导的疾病提供新方向。 【EN】The invention belongs to the technical field of immunotherapy, and firstly, dimethyl arginine is found to be capable of effectively inhibiting T, B cell proliferation in vitro, under the discovery, the mechanism of inhibiting T, B cell proliferation in vivo by ADMA and SDMA is researched, and the ADMA and SDMA are found to induce mitochondrial ROS generation through activating AGXT2 enzyme, and the ADMA and SDMA are converted into a new substance, namely dimethyl guanidine pentanoate (DMGV). Therefore, ADMA, SDMA and DMGV can effectively inhibit T, B cell proliferation; in addition, ADMA is converted to L-citrulline by dimethylamine hydrolase (DDAH), and therefore the amount of ADMA that enters mitochondria and is converted to DMGV and acts can be reduced, and the specific DDAH inhibitor PD404182, like ADMA, can also inhibit T cell proliferation. Therefore, the dimethylarginine and the derivative thereof and the substance which specifically inhibits the degradation of the dimethylarginine are expected to provide a new direction for treating T, B cell-mediated diseases by inhibiting the abnormal proliferation of T, B cells.
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申请号:202010069416.4 公开号:CN111258058A 主分类号:G02B27/00
摘要:【中文】本发明提供一种柔性遥感卫星光学镜片,包括柔性衬底和设于柔性衬底的至少一个表面上的微纳结构超表面,所述微纳结构超表面为微纳结构单元的周期性阵列,不同的微纳结构单元具有相同的高度、相同的指向角度和不同的横截面尺寸,各微纳结构单元的横截面尺寸根据所需的电磁波通过各微纳结构单元后的相位累积以及电磁波通过微纳结构单元的相位累积与微纳结构单元的横截面尺寸的对应关系相应确定。本发明还提供该遥感卫星光学镜片的制作方法。本发明的遥感卫星光学镜片不仅能实现光学聚焦功能,还能折叠运输、使用时展开,以满足遥感卫星光学镜片的大口径和轻量化需求。 【EN】The invention provides a flexible remote sensing satellite optical lens which comprises a flexible substrate and a micro-nano structure super surface arranged on at least one surface of the flexible substrate, wherein the micro-nano structure super surface is a periodic array of micro-nano structure units, different micro-nano structure units have the same height, the same pointing angle and different cross section sizes, and the cross section size of each micro-nano structure unit is correspondingly determined according to the phase accumulation of required electromagnetic waves after passing through each micro-nano structure unit and the corresponding relation between the phase accumulation of the electromagnetic waves after passing through the micro-nano structure units and the cross section size of the micro-nano structure units. The invention also provides a manufacturing method of the remote sensing satellite optical lens. The remote sensing satellite optical lens disclosed by the invention not only can realize an optical focusing function, but also can be folded, transported and unfolded in use so as to meet the requirements of large caliber and light weight of the remote sensing satellite optical lens.
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申请号:202010069442.7 公开号:CN111258059A 主分类号:G02B27/00
摘要:【中文】本发明提供了一种柔性手机摄像头光学镜片,包括柔性衬底、设于其表面上的微纳结构超表面和设于其后端的偏振片,微纳结构超表面为微纳结构单元的周期性阵列,不同微纳结构单元具有相同的尺寸和不同的指向角度,指向角度根据所需的电磁波通过各微纳结构单元后的相位累积以及相位累积与指向角度的对应关系相应确定。本发明还提供该光学镜片的制作方法。本发明的光学镜片通过将微纳结构超表面与柔性衬底结合,不仅能实现光学聚焦功能,还能弯曲折叠,且展开后不影响其光学性能,解决了手机摄像头传统光学镜片依赖于表面形状的问题,为手机摄像头光学镜片不可折叠的问题提供了一种解决方案,以满足柔性屏手机对可弯曲折叠的手机摄像头光学镜片的需求。 【EN】The invention provides a flexible mobile phone camera optical lens, which comprises a flexible substrate, a micro-nano structure super surface arranged on the surface of the flexible substrate and a polaroid arranged at the rear end of the flexible substrate, wherein the micro-nano structure super surface is a periodic array of micro-nano structure units, different micro-nano structure units have the same size and different pointing angles, and the pointing angles are correspondingly determined according to phase accumulation of required electromagnetic waves after passing through each micro-nano structure unit and the corresponding relation between the phase accumulation and the pointing angles. The invention also provides a manufacturing method of the optical lens. According to the optical lens, the micro-nano structure super-surface is combined with the flexible substrate, so that the optical focusing function can be realized, the optical lens can be bent and folded, the optical performance of the optical lens is not influenced after the optical lens is unfolded, the problem that the traditional optical lens of a mobile phone camera depends on the surface shape is solved, a solution is provided for the problem that the optical lens of the mobile phone camera is not foldable, and the requirement of a flexible screen mobile phone on the bendable and foldable optical lens of the mobile phone camera is met.
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申请号:202010199594.9 公开号:CN111255684A 主分类号:F04C18/16
申请人:【中文】福州市虚谷技术有限公司【EN】Fuzhou Xugu Technology Co., Ltd 申请日:2020.03.20 公开日:2020.06.09
摘要:【中文】本发明涉及一种半封闭螺杆压缩机,包括壳体、电机、阴阳转子、油流调节装置、自感应内容积比自动调节装置、立式油分离器、能调滑阀结构和保护控制系统,具有油流量自动调节的功能,能防止过多的油进入压缩腔,降低功耗;自感应内容积比自动调节,消除过压缩与欠压缩,提高压缩效率;实现高效的立式油分,为制冷系统提供一个含油率非常低的排气气体,提高系统的整体效率。 【EN】The invention relates to a semi-closed screw compressor, which comprises a shell, a motor, a male rotor, a female rotor, an oil flow adjusting device, a self-induction internal volume ratio automatic adjusting device, a vertical oil separator, a valve adjusting structure and a protection control system, wherein the oil flow adjusting device has the function of automatically adjusting oil flow, can prevent excessive oil from entering a compression cavity and reduce power consumption; the self-induction internal volume ratio is automatically adjusted, over-compression and under-compression are eliminated, and the compression efficiency is improved; the high-efficiency vertical oil separation is realized, the exhaust gas with very low oil content is provided for the refrigerating system, and the overall efficiency of the system is improved.
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申请号:201911396619.8 公开号:CN111222550A 主分类号:G06K9/62
摘要:【中文】本发明提供一种用户用电行为确定方法和装置,基于用户用电功率以及预先确定的聚类有效性指标确定最优聚类维度;基于最优聚类维度确定最优聚类种类数;基于最优聚类维度和最优聚类种类数,对用户用电功率进行集成聚类,得到各类用户用电行为模式,可靠性高,且能够确定用户用电行为模式;基于多种单一聚类算法,并采用多数投票法对用户用电功率进行集成聚类,针对随机性负荷具有鲁棒性,聚类误差范围小,聚类结果受噪声、孤立点、采样方法及敏感参数等因素影响较小,保证了用电用户行为聚类的有效性,为后续用户电价制定,需求响应等政策的制定提供了基础。 【EN】The invention provides a method and a device for determining user power utilization behaviors, which are used for determining an optimal clustering dimension based on user power utilization power and a predetermined clustering effectiveness index; determining the optimal clustering type number based on the optimal clustering dimension; based on the optimal clustering dimension and the optimal clustering type number, the power utilization power of the users is subjected to integrated clustering to obtain various power utilization behavior patterns of the users, the reliability is high, and the power utilization behavior patterns of the users can be determined; based on various single clustering algorithms, the power utilization power of the users is subjected to integrated clustering by adopting a majority voting method, the clustering method has robustness for random loads, the clustering error range is small, the clustering result is less influenced by factors such as noise, isolated points, sampling methods and sensitive parameters, the effectiveness of power utilization user behavior clustering is ensured, and a foundation is provided for subsequent user power price formulation, demand response and other policies.
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申请号:202010108351.X 公开号:CN111166170A 主分类号:A47J31/00
申请人:【中文】南京工程学院【EN】NANJING INSTITUTE OF TECHNOLOGY 申请日:2020.02.21 公开日:2020.05.19
摘要:【中文】本发明涉及一种智能可控水量与水温的饮水机,包括凹形打水台、集成有控制模块的显示及控制面板、冷水箱、热水箱、电位器和电机;所述的凹形打水台上方设有饮水机水嘴,所述饮水机水嘴的正下方对应的打水台台面上的位置为定位圆;所述的凹形打水台侧壁上设有竖向的刻度线,在凹形打水台后侧设有红外显像仪,所述的红外显像仪连接所述的显示及控制面板;所述的冷水箱与热水箱的阀门分别连接电位器,所述的冷水箱、热水箱内分别设有温度传感器,所述的电位器及温度传感器均与显示及控制面板连接。本发明的智能可控水量与水温的饮水机能够根据使用需要可灵活进行操作打水,使用方便、效率高、安全性好,适于推广普及。 【EN】The invention relates to an intelligent water dispenser capable of controlling water quantity and water temperature, which comprises a concave water pumping platform, a display and control panel integrated with a control module, a cold water tank, a hot water tank, a potentiometer and a motor, wherein the display and control panel is connected with the control module; a water nozzle of the water dispenser is arranged above the concave water fetching platform, and a positioning circle is arranged at a position on the platform surface of the water fetching platform corresponding to the position under the water nozzle of the water dispenser; the side wall of the concave water pumping platform is provided with vertical scale marks, the rear side of the concave water pumping platform is provided with an infrared imaging instrument, and the infrared imaging instrument is connected with the display and control panel; valves of the cold water tank and the hot water tank are respectively connected with a potentiometer, temperature sensors are respectively arranged in the cold water tank and the hot water tank, and the potentiometers and the temperature sensors are both connected with a display and control panel. The intelligent water dispenser with controllable water volume and water temperature can flexibly operate to pump water according to use requirements, is convenient to use, high in efficiency and good in safety, and is suitable for popularization.
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申请号:201911042191.7 公开号:CN111129303A 主分类号:H01L49/02
摘要:【中文】一种纠缠电感结构的纠缠载流结构。纠缠电感结构在结构中产生相反极性的内部磁场,以大致上降低或消除传播至纠缠电感结构外部的外部磁场。传播至纠缠电感结构外部的这些减少的外部磁场有效地减少纠缠电感结构与其他电气、机械及/或机电元件之间的避开区域。与产生更大外部磁场的已知电感相比,如此允许纠缠电感结构在集成电路之内更靠近这些其他电气、机械及/或机电元件定位。 【EN】An entanglement current-carrying structure of an entanglement inductance structure. The entanglement inductance structure generates internal magnetic fields of opposite polarity within the structure to substantially reduce or eliminate external magnetic fields propagating outside the entanglement inductance structure. These reduced external magnetic fields propagating outside the entanglement inductance structure effectively reduce the exclusion area between the entanglement inductance structure and other electrical, mechanical, and/or electromechanical elements. This allows the intertwined inductive structures to be positioned closer to these other electrical, mechanical and/or electromechanical elements within the integrated circuit than known inductors that generate larger external magnetic fields.
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申请号:201911188326.0 公开号:CN111244081A 主分类号:H01L25/18
摘要:【中文】一种集成电路装置,例如一计算机系统,包括一互连元件晶粒及至少两个附加集成晶片上系统(System on Integrated Chip,SOIC)晶粒以面朝面(Face to Face,F2F)堆叠于该互连元件晶粒上。该互连元件晶粒包括在一表面上的电连接器,以致能连接到和/或多个附加SOIC晶粒之间。该互连元件晶粒包括是一集成扇出结构(Integrated Fan Out,InFO)的至少一重布电路结构及至少一硅穿孔(Through‑Silicon Via,TSV)。该TSV致能于一信号线、电源线或地线之间,从该互连元件晶粒的一相对表面至该重布电路结构和/或电连接器的连结。该附加SOIC晶粒的至少一个堆叠成面朝背(Face to Back,F2B)的一个三维集成电路(Three‑Dimensional Integrated Circuit,3DIC)晶粒。 【EN】An Integrated circuit device, such as a computer System, includes an interconnection device die and at least two System On Integrated Chip (SOIC) dies stacked on the interconnection device die in a Face to Face (F2F) orientation. The interconnection device die includes electrical connectors on a surface that enable connection to and/or between a plurality of additional SOIC dies. The interconnection device die includes at least one redistribution circuit structure (redistribution-Via) that is an Integrated Fan-Out (InFO) structure and at least one Through-Silicon Via (TSV). The TSV enables a connection between a signal line, power line, or ground line from an opposite surface of the interconnection device die to the redistribution circuit structure and/or electrical connector. At least one of the additional SOIC dies is stacked as a Three-Dimensional Integrated Circuit (3DIC) die facing Back (Face to Back, F2B).
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申请号:202010003186.1 公开号:CN110951656A 主分类号:C12N1/20
申请人:【中文】山东农业大学【EN】Shandong Agricultural University 申请日:2020.01.02 公开日:2020.04.03
摘要:【中文】本发明公开了一株乙酰微小杆菌及其在防治根结线虫病中的应用,本发明提供的乙酰微小杆菌(Exiguobacterium acetylicum)AMCC 101217,保藏编号为CGMCC No.16305;该菌可有效地防治番茄根结线虫病,其卵囊数、根结数、虫口密度相比于空白对照分别下降了84.69%、65.86%和73.24%;该菌同时也有效地减轻了根结线虫病对番茄的危害,与空白对照相比,其地上部干鲜重及地下部干鲜重均差异极显著。 【EN】The invention discloses a micro-bacillus acetobacter and application thereof in preventing and treating root knot nematode disease, wherein the micro-bacillus acetobacter AMCC101217 has a preservation number of CGMCC No. 16305; the strain can effectively prevent and treat tomato root knot nematode disease, and the number of oocysts, the number of root knots and the density of insect population of the strain are respectively reduced by 84.69%, 65.86% and 73.24% compared with blank control; the strain also effectively reduces the harm of the root knot nematode disease to the tomatoes, and compared with a blank control, the difference between the dry and fresh weight of the overground part and the dry and fresh weight of the underground part is extremely obvious.
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申请号:202010001986.X 公开号:CN110964675A 主分类号:C12N1/20
申请人:【中文】山东农业大学【EN】Shandong Agricultural University 申请日:2020.01.02 公开日:2020.04.07
摘要:【中文】本发明公开了一株Sphingobacterium hotanense在防治寄生线虫病上的应用。本发明提供的Sphingobacterium hotanense AMCC 101218,保藏编号为CGMCC No.19217;该菌可有效地防治黄瓜根结线虫病,其卵囊数、根结数、虫口密度相比于空白对照分别下降了71.28%、75.86%和63.80%;AMCC101218基因组大小为4490254bp,GC含量为41.21%。 【EN】The invention discloses application of Sphingobacterium montanense in prevention and treatment of parasitic nematode. The preservation number of Sphingobacterium montanense AMCC101218 provided by the invention is CGMCC No. 19217; the strain can effectively prevent and treat cucumber root knot nematode disease, and the number of oocysts, the number of root knots and the density of insect population of the strain are respectively reduced by 71.28%, 75.86% and 63.80% compared with blank control; the AMCC101218 genome size is 4490254bp, and the GC content is 41.21%.
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