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申请号:202010129983.4 公开号:CN111233955A 主分类号:C07H19/073
摘要:【中文】一类噻唑酮甲酰胞嘧啶衍生物及其药物用途,其化学结构符合通式(I):其中:R1为CH、CF、C(CF3)或N,R2、R3为‑H或‑OH,R4、R5为‑H、‑OH或‑F。本发明所述的噻唑酮甲酰胞嘧啶衍生物,在肿瘤高自由基环境下能够释放出嘧啶类抗肿瘤活性成分,产生较强的细胞毒性。具有优异的抗肿瘤作用和良好的安全性,可用于治疗肿瘤药物的制备。 【EN】Thiazole ketone formyl cellPyrimidine derivatives and their pharmaceutical use, the chemical structure of which corresponds to the general formula (I):wherein: r1Is CH, CF, C (CF)3) Or N, R2、R3is-H or-OH, R4、R5is-H, -OH or-F. The thiazolone formyl cytosine derivative can release pyrimidine anti-tumor active ingredients under the environment of high free radicals of tumors, and generates stronger cytotoxicity. Has excellent antitumor effect and good safety, and can be used for preparing medicine for treating tumor.
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申请号:201911211355.4 公开号:CN110887824A 主分类号:G01N21/64
摘要:【中文】本发明公开了一种可集成模块化过氧化物检测装置及其检测方法。本发明将各个子单元进行整合模块化集成,完成对过氧化物的检测;当无被检物质时,检测装置处于待机状态;当被检物质靠近检测装置时,检测装置完全启动,并对被检物质进行检测,通过对检测晶片反应前后光信号的变化进行分析处理,判断其是否含有过氧化物,并给出相应的警示信号,本发明可单独使用,也可集成与安检门或安检机等安检设备上,实现对过氧化物的实时、快速、准确的检测,为实现新型过氧化物检测提供新的途径。 【EN】The invention discloses an integratable modular peroxide detection device and a detection method thereof. According to the invention, each subunit is integrated in an integrated and modularized manner, so that the detection of peroxide is completed; when no detected substance exists, the detection device is in a standby state; when the detected substance approaches the detection device, the detection device is completely started, the detected substance is detected, whether the detected substance contains peroxide or not is judged by analyzing and processing the change of optical signals before and after the reaction of the detection wafer, and a corresponding warning signal is given.
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申请号:202010202159.7 公开号:CN111230608A 主分类号:B24B1/04
摘要:【中文】本发明公开了螺旋管技术领域的一种螺旋管管端修磨装置及方法,包括主板,主板的右侧安装设置有电推杆,电推杆的左侧贯穿主板并固接有侧板,主板上开设有两组前后对称的限位槽,限位槽内滑动连接有限位杆,两组限位杆均固接于侧板上,主板的底部固接有弧形座,侧板的左侧安装设置有电机,电机的右侧动力输出端固接有转杆,转杆通过轴承与侧板转动连接,侧板的右侧开设有振动槽,转杆的侧壁固接有摆板,摆板上开设有振动腔,振动腔内设置有修磨板,修磨板的左侧固接有振动电机,且振动电机设置于振动槽内。本发明无需人工操作,省时省力;提高装置稳定性,提高修磨效率,便于对不同尺寸的螺旋管进行修磨,适用范围广。 【EN】The invention discloses a spiral pipe end grinding device and a spiral pipe end grinding method in the technical field of spiral pipes, and the spiral pipe end grinding device comprises a main board, wherein an electric push rod is arranged on the right side of the main board, the left side of the electric push rod penetrates through the main board and is fixedly connected with a side board, two sets of front and back symmetrical limiting grooves are formed in the main board, limiting rods are connected in the limiting grooves in a sliding mode, the two sets of limiting rods are fixedly connected onto the side board, an arc-shaped seat is fixedly connected to the bottom of the main board, a motor is arranged on the left side of the side board, a rotating rod is fixedly connected to the power output end of the right side of the motor and is rotatably connected with the side board through a bearing, a vibration groove is formed in the right side of the side board, a swing plate is fixedly connected to the side. The invention does not need manual operation, and saves time and labor; the stability of the device is improved, the grinding efficiency is improved, the grinding of spiral pipes with different sizes is facilitated, and the application range is wide.
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申请号:202010202162.9 公开号:CN111266922A 主分类号:B23Q11/10
摘要:【中文】本发明公开了一种具有降温功能的钢板加工工装,涉及钢板加工技术领域,包括底座、工作台、X型升降台、L型的第一支架和第二支架,工作台的后端设有降温装置,降温装置包括设在工作台上方的上降温总管和下方的下降温总管,上降温总管、工作台、下降温总管之间为交错安装,冷风机将风吹至工作台上;第二电动机上的齿形圆切刀通延伸托架前端的红外定位感应器定位后进行切割。本发明通过利用螺杆和横梁以及滑块之间的相互运动带动切割滑板滑动;设定红外定位感应器便于快速精确的定位要切割钢板的位置,通过在工作台的上下方设置降温总管,并通过倾斜设置的出风嘴将冷风至切割区域,能够及时并且有效的达到降温的效果。 【EN】The invention discloses a steel plate processing tool with a cooling function, which relates to the technical field of steel plate processing and comprises a base, a workbench, an X-shaped lifting table, an L-shaped first support and a second support, wherein the rear end of the workbench is provided with a cooling device, the cooling device comprises an upper cooling main pipe arranged above the workbench and a lower cooling main pipe arranged below the workbench, the upper cooling main pipe, the workbench and the lower cooling main pipes are installed in a staggered manner, and an air cooler blows air onto the workbench; the tooth-shaped circular cutter on the second motor cuts after being positioned by the infrared positioning sensor at the front end of the extension bracket. The cutting slide plate is driven to slide by utilizing the mutual motion among the screw rod, the cross beam and the slide block; set for the position that infrared positioning sensor is convenient for quick accurate location and will cuts the steel sheet, set up the cooling house steward through the upper and lower side at the workstation to the air outlet nozzle that sets up through the slope will cool wind to cutting region, can be in time and the effectual effect that reaches the cooling.
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申请号:201911157117.X 公开号:CN110882583A 主分类号:B01D45/08
申请人:【中文】华中科技大学【EN】HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY 申请日:2019.11.22 公开日:2020.03.17
摘要:【中文】本发明属于脱硫装置领域,并公开了一种烟气脱硫系统中的多孔除雾器。该除雾器包括壳体、多个叶片和设置在叶片上的多孔板,其中,叶片和多孔板设置在壳体中,该叶片呈波纹状,叶片和叶片之间形成烟气通道,待处理的烟气在该烟气通道中流通,多孔板设置在烟气通道中液体聚集区域,多孔板上设置有多个均匀分布的通孔,该多孔板一方面用于拦截待处理烟气中的液体,使得液体在该多孔板上聚集,另一方面通孔避免烟气通道中气流压降的损失。通过本发明,结构简单,稳定可靠,压降较低,除雾效率高,且不易结垢堵塞。 【EN】The invention belongs to the field of desulfurization devices, and discloses a porous demister in a flue gas desulfurization system. This defroster includes the casing, a plurality of blades and the perforated plate of setting on the blade, wherein, blade and perforated plate setting are in the casing, this blade is the corrugate, form the flue gas passageway between blade and the blade, pending flue gas circulates in this flue gas passageway, the perforated plate setting is regional in liquid gathering in the flue gas passageway, be provided with a plurality of evenly distributed's through-hole on the perforated plate, this perforated plate is arranged in intercepting the liquid in the pending flue gas on the one hand, make liquid gather on this perforated plate, on the other hand through-hole avoids the loss of air current pressure drop in the flue gas passageway. The invention has the advantages of simple structure, stability, reliability, lower pressure drop, high demisting efficiency and difficult scaling and blockage.
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申请号:201911283110.2 公开号:CN111014893A 主分类号:B23K9/133
摘要:【中文】本发明提供一种成型气氛室外连续送丝装置,包括:成型气氛室和送丝机构,还包括气氛过渡室,所述气氛过渡室设置在所述成型气氛室的外侧壁上,所述送丝机构设置在气氛过渡室远离成型气氛室的一侧,并通过所述气氛过渡室向所述成型气氛室送丝。本发明还提供一种成型气氛室外连续送丝方法,进行大型钛合金、不锈钢等零件的增材制造。本发明提供的成型气氛室外连续送丝装置及其方法,在成型过程中更换新丝时无需打开成型气氛室,在成型气氛室外完成接丝操作,避免打开成型气氛室后需重新置换成型气氛室内的空气,可大幅提高大型钛合金、不锈钢等零件的成型效率,大幅降低大型金属零件电弧增材制造的生产周期、惰性气体消耗和开裂风险。 【EN】The invention provides an outdoor continuous wire feeding device for forming atmosphere, which comprises: forming atmosphere room and thread feeding mechanism still include atmosphere transition room, atmosphere transition room sets up on the lateral wall of forming atmosphere room, thread feeding mechanism sets up the one side of keeping away from forming atmosphere room in atmosphere transition room, and passes through atmosphere transition room to forming atmosphere room send a silk. The invention also provides an outdoor continuous wire feeding method under the forming atmosphere, which is used for additive manufacturing of parts such as large titanium alloy, stainless steel and the like. According to the forming atmosphere outdoor continuous wire feeding device and the forming atmosphere outdoor continuous wire feeding method, the forming atmosphere chamber does not need to be opened when a new wire is replaced in the forming process, wire splicing operation is completed outside the forming atmosphere chamber, the situation that air in the forming atmosphere chamber needs to be replaced again after the forming atmosphere chamber is opened is avoided, the forming efficiency of parts such as large titanium alloy and stainless steel can be greatly improved, and the production period, inert gas consumption and cracking risk of electric arc additive manufacturing of large metal parts are greatly reduced.
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申请号:201910822596.6 公开号:CN110840907A 主分类号:A61K31/7072
申请人:【中文】南京医科大学【EN】NANJING MEDICAL University 申请日:2019.09.02 公开日:2020.02.28
摘要:【中文】一类自由基敏感的尿嘧啶类ProTide前药及其药物用途,其化学结构符合通式(I):其中:Ar为R为‑F或‑CF3。本发明所述的自由基敏感的尿嘧啶类ProTide前药在自由基条件下能够释放出尿嘧啶类抗肿瘤活性成分,产生较强的细胞毒性。具有优异的抗肿瘤作用和良好的安全性,可用于治疗肿瘤药物的制备。 【EN】A free radical sensitive uracil ProTide prodrug and its pharmaceutical use, its chemical structure conforms to the general formula (I):wherein: ar isR is-F or-CF3. The uracil ProTide prodrug sensitive to free radicals can release uracil antitumor active ingredients under the condition of free radicals, and generates stronger cytotoxicity. Has excellent antitumor effect and good safety, and can be used for preparing medicine for treating tumor.
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申请号:201911325116.1 公开号:CN111014883A 主分类号:B23K9/04
摘要:【中文】本发明提供一种电弧熔丝增材制造装置,包括:路径执行机构、变位机机构、平台机构和焊接机构,所述平台机构包括柔性平台、悬臂和装夹组件;所述柔性平台为具有一定厚度的八边形平台,所述悬臂为截面为U型的方箱,所述柔性平台和悬臂表面均分布有若干定位孔,所述悬臂通过锁紧件可拆卸地安装于柔性平台的四周。采用上述装置进行生产具有无需模具,直接成型的特点,能够同时满足大尺寸和复杂结构筋条的回转体类零件的成型。该装置成型质量好、效率高、构件力学性能好、制造成本低,具有广泛的应用前景。 【EN】The invention provides an arc fuse additive manufacturing device, which comprises: the device comprises a path executing mechanism, a positioner mechanism, a platform mechanism and a welding mechanism, wherein the platform mechanism comprises a flexible platform, a cantilever and a clamping assembly; the flexible platform is the octagon platform that has certain thickness, the cantilever is the square chest of cross-section for the U type, flexible platform and cantilever surface evenly distributed have a plurality of locating holes, the cantilever passes through retaining member detachably and installs around flexible platform. The device has the characteristics of direct molding without a mold during production, and can simultaneously meet the molding requirements of the revolving body parts with ribs of large sizes and complex structures. The device has the advantages of good forming quality, high efficiency, good mechanical property of the component, low manufacturing cost and wide application prospect.
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申请号:201911270781.5 公开号:CN111014881A 主分类号:B23K9/04
摘要:【中文】本申请公开了一种薄壁圆台类结构的制造方法,包括:将基板装夹于变位机平台上,确定基板的倾斜角度;确定焊枪的初始位置;使用所述焊枪,通过电弧熔丝在所述基板上增材成型;对所述成型过程进行角度校正。还包括对所述薄壁圆台类结构进行热处理;对完成所述热处理的所述薄壁圆台类结构进行机加工。本发明还公开了使用上述方法制造薄壁圆台类结构的装置。采用本发明的方法及装置,整个成型过程无需模具,相对于传统的锻造和铸造方法大大缩短了加工时间,成型的锥筒结构尺寸精确。 【EN】The application discloses a manufacturing method of a thin-wall round table structure, which comprises the following steps: clamping the substrate on a positioner platform, and determining the inclination angle of the substrate; determining an initial position of a welding gun; using the welding torch, performing additive forming on the substrate through an arc fuse; and correcting the angle of the forming process. The method also comprises the step of carrying out heat treatment on the thin-wall round platform type structure; and machining the thin-wall round table structure subjected to the heat treatment. The invention also discloses a device for manufacturing the thin-wall round table type structure by using the method. By adopting the method and the device, a die is not needed in the whole forming process, the processing time is greatly shortened compared with the traditional forging and casting method, and the formed conical cylinder structure has accurate size.
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申请号:202010046052.8 公开号:CN111193246A 主分类号:H02H7/26
摘要:【中文】本发明涉及一种计及运行方式与开关特性的故障切除方法,包括如下步骤:1)选取故障元件,2)计算故障电阻的大小,通过电气采集信息,还原出故障电阻的大小;3)选取免扩大动作的断路器;4)选取需考虑扩大动作的断路器;5)基于动作条件的形成断路器动作时序配合。本发明所述的计及运行方式与开关特性的故障切除方法,建立起断路器的动作时限,保障断路器能够动作于遮断电流以内,并能使得故障的切除范围与动作时间尽可能的减小。 【EN】The invention relates to a fault removal method considering an operation mode and switching characteristics, which comprises the following steps of: 1) selecting a fault element, 2) calculating the size of the fault resistor, and restoring the size of the fault resistor through electrically acquiring information; 3) selecting a breaker free of expansion action; 4) selecting a breaker needing to consider the expansion action; 5) and forming circuit breaker action timing coordination based on the action conditions. The fault removing method considering the operation mode and the switching characteristic establishes the action time limit of the breaker, ensures that the breaker can act within the breaking current, and can reduce the removing range and the action time of the fault as much as possible.
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