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1:
[发明]
【中文】一种基于CD19和CD30的双重嵌合抗原受体基因修饰的免疫细胞及其应用 【EN】CD19 and CD30 based double chimeric antigen receptor gene modified immune cell and application thereof
申请号:
201811458441.0
公开号:CN110951689A 主分类号:C12N5/10
申请人:
【中文】北京美康基免生物科技有限公司【EN】BEIJING MEIKANG GENO-IMMUNE BIOTECHNOLOGY Co.,Ltd.
申请日:2018.11.30 公开日:2020.04.03
发明人:
【中文】李昱琛【EN】
Li Yuchen
摘要:【中文】本发明涉及一种基于CD19和CD30的双重嵌合抗原受体基因修饰的免疫细胞及其应用,所述双重嵌合抗原受体包括嵌合抗原受体CD19和嵌合抗原受体CD30。所述嵌合抗原受体包括抗原结合结构域、跨膜结构域、共刺激信号传导区和CD3ζ信号传导结构域以及可诱导自杀融合结构域串联而成。本发明的嵌合抗原受体能特异性的识别肿瘤表面抗原CD19和CD30,相比于使用其他单一嵌合抗原受体T细胞,联合使用两种抗原靶向CAR‑T细胞针对CD19阴性复发,以及CD19低表达的B细胞肿瘤使得治疗效果更好,更容易让疾病缓解。 【EN】The invention relates to a CD19 and CD 30-based double chimeric antigen receptor gene modified immune cell and application thereof, wherein the double chimeric antigen receptor comprises a chimeric antigen receptor CD19 and a chimeric antigen receptor CD 30. The chimeric antigen receptor comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, in tandem with an inducible suicide fusion domain. The chimeric antigen receptor can specifically recognize tumor surface antigens CD19 and CD30, and compared with other single chimeric antigen receptor T cells, two antigens are combined to target CAR-T cells to negative relapse of CD19, and B cell tumors with low expression of CD19 have better treatment effect and are easier to relieve diseases.
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2:
[发明]
【中文】一种多频段指示方法和通信设备 【EN】Multi-frequency band indication method and communication equipment
申请号:
201811320739.5
公开号:CN111162885A 主分类号:H04L5/00
申请人:
【中文】华为技术有限公司【EN】HUAWEI TECHNOLOGIES Co.,Ltd.
申请日:2018.11.07 公开日:2020.05.15
发明人:
【中文】郭宇宸
;
李云波【EN】Guo Yuchen
;
Li Yunbo
摘要:【中文】本申请实施例公开了一种多频段指示方法和通信设备,用于实现在多频段聚合场景下的频段指示,提高资源使用效率。本申请实施例提供一种多频段指示方法,包括:第一通信设备生成第一帧,所述第一帧包括:第一操作等级字段,其中,当所述第一通信设备建立的基本服务集BSS同时工作在第一频段和第二频段时,所述第一操作等级字段用于指示所述第二频段的起始频点,所述第一频段是包括主信道的频段,第二频段是不包括所述主信道的频段;所述第一通信设备发送所述第一帧。 【EN】The embodiment of the application discloses a multi-band indication method and communication equipment, which are used for realizing frequency band indication in a multi-band polymerization scene and improving the resource utilization efficiency. The embodiment of the application provides a multi-band indication method, which comprises the following steps: a first communication device generates a first frame, the first frame comprising: a first operation level field, where when a basic service set BSS established by the first communication device operates in a first frequency band and a second frequency band simultaneously, the first operation level field is used to indicate a start frequency point of the second frequency band, the first frequency band is a frequency band including a main channel, and the second frequency band is a frequency band not including the main channel; the first communication device transmits the first frame.
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3:
[发明]
【中文】一种环保型净水剂 【EN】Environment-friendly water purifying agent
申请号:
202010148118.4
公开号:CN111186894A 主分类号:C02F1/52
申请人:
【中文】南通佳烁环保科技有限公司【EN】Nantong jiashuo Environmental Protection Technology Co., Ltd
申请日:2020.03.05 公开日:2020.05.22
发明人:
【中文】黄靓
;
李蔚
;
刘昱辰【EN】Huang Jing
;
Li Wei
;
Liu Yuchen
摘要:【中文】本发明提供了一种环保型净水剂,按质量份数计包括以下组分,硫酸铝5~8%、硫酸亚铁5~8%、次氯酸钠10~12%、电气石粉末8~13%、活性硅酸8~10%、氧化锌8~12%、聚丙烯酰胺4~6%及pH值调整剂3~5%,余量为去离子水。本发明制成的净水剂不仅能够处理色度、浓度均较高的废水,同时使该净水剂处理后的废水达到无色、无味且悬浮物、色度值明显降低。此外,使用该净水剂处理废水过程中不产生二次污染,且成本低,操作简单,便于推广。 【EN】The invention provides an environment-friendly water purifying agent which comprises, by mass, 5-8% of aluminum sulfate, 5-8% of ferrous sulfate, 10-12% of sodium hypochlorite, 8-13% of tourmaline powder, 8-10% of active silicic acid, 8-12% of zinc oxide, 4-6% of polyacrylamide, 3-5% of a pH value regulator and the balance deionized water. The water purifying agent prepared by the invention can treat wastewater with high chroma and concentration, and simultaneously, the wastewater treated by the water purifying agent is colorless and tasteless, and suspended matters and chroma values are obviously reduced. In addition, the water purifying agent does not produce secondary pollution in the process of treating wastewater, and has the advantages of low cost, simple operation and convenient popularization.
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4:
[发明]
【中文】一种西那卡塞杂质的制备方法 【EN】Preparation method of cinacalcet impurity
申请号:
202010063503.9
公开号:CN111153832A 主分类号:C07C269/00
申请人:
【中文】广州九植医药科技有限公司【EN】Guangzhou Jiuzhi Pharmaceutical Technology Co., Ltd
申请日:2020.01.20 公开日:2020.05.15
发明人:
【中文】陈卫
;
李宁
;
周宇晨【EN】Chen Wei
;
Li Ning
;
Zhou Yuchen
摘要:【中文】本发明涉及化合物制备技术领域,具体涉及一种西那卡塞杂质的制备方法,该方法是先将三光气溶于二氯甲烷中,搅拌降温至‑5‑0℃,加入碱,然后加入R‑(+)‑1‑(1‑萘基)乙胺,升温至室温18‑23℃,搅拌反应一段时间,得到中间产物II;接着,将该中间产物II溶解于二氯甲烷中,搅拌降温至‑5‑0℃,同时加入碱和3‑(3‑三氟甲基苯基)丙醇,升温至室温18‑23℃,搅拌反应一段时间,得到最终产物。本发明的制备工艺设计合理,操作简单、原料易得、纯度高、反应过程可控,所用的碱单一,所制备的西那卡塞杂质为全面分析西那卡塞的临床、药理、药代动力学和毒理提供分析研究的基准物质。 【EN】The invention relates to the technical field of compound preparation, in particular to a preparation method of cinacalcet impurity, which comprises the steps of dissolving triphosgene in dichloromethane, stirring and cooling to-5-0 ℃, adding alkali, then adding R- (+) -1- (1-naphthyl) ethylamine, heating to room temperature of 18-23 ℃, stirring and reacting for a period of time to obtain an intermediate product II; and then, dissolving the intermediate product II in dichloromethane, stirring and cooling to-5-0 ℃, simultaneously adding alkali and 3- (3-trifluoromethylphenyl) propanol, heating to room temperature of 18-23 ℃, and stirring and reacting for a period of time to obtain a final product. The preparation process disclosed by the invention is reasonable in design, simple to operate, easily available in raw materials, high in purity, controllable in reaction process and single in used alkali, and the prepared cinacalcet impurity provides a reference substance for analysis and research for comprehensively analyzing the clinical, pharmacological, pharmacokinetic and toxicological properties of cinacalcet.
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5:
[发明]
【中文】对古汉语进行断句的方法、装置以及存储介质 【EN】Method, device and storage medium for punctuating ancient Chinese
申请号:
201911084236.7
公开号:CN110909549A 主分类号:G06F40/30
申请人:
【中文】北京师范大学【EN】BEIJING NORMAL University
申请日:2019.11.07 公开日:2020.03.24
发明人:
【中文】胡韧奋
;
李绅
;
诸雨辰【EN】Hu Renfen
;
Li Shen
;
Zhu Yuchen
摘要:【中文】本申请公开了一种对古汉语进行断句的方法、装置以及存储介质。其中,该方法包括:接收与待断句的古汉语文本对应的古汉语信息;根据古汉语信息,生成第一向量集合,其中第一向量集合中的向量与古汉语文本中的汉字对应,并且与汉字在古汉语文本的语境中的含义关联;以及根据第一向量集合,利用预先设置的计算模型,生成用于对古汉语文本进行断句的标记信息。 【EN】The application discloses a method, a device and a storage medium for sentence breaking of ancient Chinese. Wherein, the method comprises the following steps: receiving ancient Chinese information corresponding to the ancient Chinese text of the sentence to be disconnected; generating a first vector set according to the ancient Chinese information, wherein vectors in the first vector set correspond to Chinese characters in the ancient Chinese text and are associated with meanings of the Chinese characters in the context of the ancient Chinese text; and generating marking information for punctuating the ancient Chinese text by utilizing a preset calculation model according to the first vector set.
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6:
[发明]
【中文】一种倍捻机废纱吸尘装置 【EN】Two-for-one twister yarn waste dust extraction
申请号:
201911412083.4
公开号:CN110983519A 主分类号:D01H11/00
申请人:
【中文】杭州观爱科技有限公司【EN】Hangzhou guanai Technology Co., Ltd
申请日:2019.12.31 公开日:2020.04.10
发明人:
【中文】温在墙
;
夏雨辰
;
李欢【EN】Wen Zaiqiang
;
Xia Yuchen
;
Li Huan
摘要:【中文】本发明公开了一种倍捻机废纱吸尘装置,包括箱体,所述箱体底部的四角均固定连接有支撑脚,所述箱体的顶部固定连接有倍捻机本体,所述箱体内壁的两侧均固定连接有水箱,所述水箱外侧的顶部连通有加水管,所述加水管的外侧贯穿至箱体的外侧,所述加水管外侧的底部连通有换水管,所述换水管的外侧贯穿至箱体的外部。本发明达到了自动吸除废纱的优点,能够自动的对废纱进行吸除,降低了工人的劳动强度,且能够吸除空气中飘洒的废纱,防止工人吸入废纱,保证了工人的身体健康,方便工人使用。 【EN】The invention discloses a waste yarn dust collection device of a two-for-one twister, which comprises a box body, wherein four corners of the bottom of the box body are fixedly connected with supporting legs, the top of the box body is fixedly connected with a two-for-one twister body, two sides of the inner wall of the box body are fixedly connected with water tanks, the top of the outer side of each water tank is communicated with a water adding pipe, the outer side of each water adding pipe penetrates through the outer side of the box body, the bottom of the outer side of each water adding pipe is communicated with a water changing pipe, and the outer side of each water changing. The waste yarn suction device has the advantages of automatically sucking and removing waste yarns, can automatically suck and remove the waste yarns, reduces the labor intensity of workers, can suck and remove the waste yarns floating in the air, prevents the workers from sucking the waste yarns, ensures the health of the workers, and is convenient for the workers to use.
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7:
[发明]
【中文】一种旋风式燃烧火化炉 【EN】Cyclone combustion cremator
申请号:
202010005274.5
公开号:CN111140848A 主分类号:F23G1/00
申请人:
【中文】杭州止墨机械技术咨询有限公司【EN】Hangzhou Zhimo Machinery Technology Consulting Co., Ltd
申请日:2020.01.03 公开日:2020.05.12
发明人:
【中文】夏雨辰
;
李伯泉
;
戴桂兰【EN】Xia Yuchen
;
Li Boquan
;
Dai Guilan
摘要:【中文】本发明公开了一种旋风式燃烧火化炉,包括火化炉本体,所述火化炉本体顶部的右侧设置有转动盘,所述转动盘的底部固定连接有转动杆,所述转动杆的底部贯穿火化炉本体并延伸至火化炉本体的内部固定连接有第一斜齿轮,所述第一斜齿轮的底部设置有第二斜齿轮,所述第二斜齿轮与第一斜齿轮啮合。本发明通过设置火化炉本体、转动盘、转动杆、第一斜齿轮、第二斜齿轮、螺纹杆、螺纹套、移动板、电机、第一传动齿轮、第二传动齿轮、转动柱和风扇的配合,使风扇旋转,通过风扇吹出风,通过风力助燃,且防止水分流入燃烧室,保证充分燃烧,从而达到了可以充分燃烧的效果,解决了现有的燃烧火化炉不能充分燃烧的问题。 【EN】The invention discloses a cyclone combustion cremator, which comprises a cremator body, wherein a rotating disc is arranged on the right side of the top of the cremator body, a rotating rod is fixedly connected to the bottom of the rotating disc, a first helical gear is fixedly connected to the bottom of the rotating rod, penetrates through the cremator body and extends to the interior of the cremator body, a second helical gear is arranged at the bottom of the first helical gear, and the second helical gear is meshed with the first helical gear. According to the invention, the cremator body, the rotating disc, the rotating rod, the first helical gear, the second helical gear, the threaded rod, the threaded sleeve, the moving plate, the motor, the first transmission gear, the second transmission gear, the rotating column and the fan are matched, so that the fan rotates, air is blown out by the fan, combustion is supported by wind power, moisture is prevented from flowing into the combustion chamber, and sufficient combustion is ensured, thereby achieving the effect of sufficient combustion and solving the problem that the existing combustion cremator cannot sufficiently combust.
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8:
[发明]
【中文】一种分体式斜向配合燃烧器火盖的对称式锻造模具 【EN】Symmetrical forging die of split type slant cooperation combustor fire lid
申请号:
202010005301.9
公开号:CN111136207A 主分类号:B21J13/02
申请人:
【中文】杭州止距智能技术有限公司【EN】Hangzhou stop distance intelligent technology Co., Ltd
申请日:2020.01.03 公开日:2020.05.12
发明人:
【中文】夏雨辰
;
李欢
;
王沈跃【EN】Xia Yuchen
;
Li Huan
;
Wang Shenyue
摘要:【中文】本发明公开了一种分体式斜向配合燃烧器火盖的对称式锻造模具,包括锻造模具本体,所述锻造模具本体的内部活动连接有分离火盖,分离火盖左侧的底部固定连接有固定件,固定件正面的左侧设置有移动盘。本发明通过设置锻造模具本体、分离火盖、固定件、移动盘、传动柱、移动板、滑动块、滑动套、移动柱、卡杆和配套件的配合,使两个分离火盖可以相互连接形成火盖,在毁坏时只需要将毁坏的分离火盖进行更换便可,从而达到了生产出的火盖可以分离的效果,解决了现有的斜向配合燃烧器火盖的对称式锻造模具生产出的火盖不能分离的问题,该分体式斜向配合燃烧器火盖的对称式锻造模具,具备生产出的火盖可以分离的优点。 【EN】The invention discloses a symmetrical forging die of a split type inclined matching burner fire cover, which comprises a forging die body, wherein a separated fire cover is movably connected inside the forging die body, the bottom of the left side of the separated fire cover is fixedly connected with a fixing piece, and a movable disc is arranged on the left side of the front side of the fixing piece. According to the invention, through the matching of the forging die body, the separation fire covers, the fixing part, the moving plate, the transmission column, the moving plate, the sliding block, the sliding sleeve, the moving column, the clamping rod and the matching part, the two separation fire covers can be connected with each other to form the fire cover, and only the damaged separation fire cover needs to be replaced when damaged, so that the produced fire cover can be separated, and the problem that the fire cover produced by the existing symmetrical forging die obliquely matched with the burner fire cover cannot be separated is solved.
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9:
[发明]
【中文】一种致密偏铌酸铅压电陶瓷材料及其制备方法 【EN】Compact lead metaniobate piezoelectric ceramic material and preparation method thereof
申请号:
201911266838.4
公开号:CN111087243A 主分类号:C04B35/497
申请人:
【中文】中国科学院上海硅酸盐研究所【EN】SHANGHAI INSTITUTE OF CERAMICS, CHINESE ACADEMY OF SCIENCES
申请日:2019.12.11 公开日:2020.05.01
发明人:
【中文】周志勇
;
李玉臣
;
董显林【EN】Zhou Zhiyong
;
Li Yuchen
;
Dong Xianlin
摘要:【中文】本发明公开一种致密偏铌酸铅压电陶瓷材料及其制备方法。所述偏铌酸铅压电陶瓷材料的化学组成为Pb
1‑x
Nb
2
O
6
,其中,x表示钨青铜型晶体结构中A位Pb的缺位浓度,0.00<x≤0.20。 【EN】The invention discloses a compact lead metaniobate piezoelectric ceramic material and a preparation method thereof. The chemical composition of the lead meta-niobate piezoelectric ceramic material is Pb
1‑x
Nb
2
O
6
Wherein x represents the defect site concentration of A site Pb in the tungsten bronze crystal structure, and x is more than 0.00 and less than or equal to 0.20.
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10:
[发明]
【中文】一种差分带通式调频MEMS陀螺仪速率解析装置及方法 【EN】Differential band-pass type frequency modulation MEMS gyroscope rate analysis device and method
申请号:
202010108635.9
公开号:CN111256729A 主分类号:G01C25/00
申请人:
【中文】中国海洋大学【EN】OCEAN UNIVERSITY OF CHINA
申请日:2020.02.21 公开日:2020.06.09
发明人:
【中文】李崇
;
王雨晨
;
侯佳坤【EN】Li Chong
;
Wang Yuchen
;
Hou Jiakun
摘要:【中文】本发明属于陀螺仪信号处理技术领域,具体公开了一种差分带通式调频MEMS陀螺仪速率解析装置及方法。其中,装置包括模拟电路部分和数字电路部分。模拟电路部分用于实现MEMS陀螺仪的模拟信号采集。而数字电路部分包括数字信号测频电路、数字信号解调电路以及数字信号滤波电路。数字电路部分主要用于完成对MEMS陀螺仪信号的测频、解调以及滤波等处理。本发明中MEMS陀螺仪速率的解析工作均在数字电路中完成,因而能够有效避免在模拟电路区域大量引入晶体振荡器信号,从而保证装置拥有良好的电磁兼容性。同时由于数字电路不易受到环境影响的特性,因此,本发明在极端环境下仍能精准的解析陀螺角速率。另外,本发明中装置的信噪比得到提升。 【EN】The invention belongs to the technical field of gyroscope signal processing, and particularly discloses a differential band-pass type frequency modulation MEMS gyroscope rate analysis device and method. The device comprises an analog circuit part and a digital circuit part. The analog circuit part is used for realizing the analog signal acquisition of the MEMS gyroscope. And the digital circuit part comprises a digital signal frequency measuring circuit, a digital signal demodulating circuit and a digital signal filtering circuit. The digital circuit part is mainly used for completing the processing of frequency measurement, demodulation, filtering and the like of MEMS gyroscope signals. The MEMS gyroscope speed analysis work is completed in a digital circuit, so that a large number of crystal oscillator signals can be effectively prevented from being introduced into an analog circuit area, and the device is ensured to have good electromagnetic compatibility. Meanwhile, due to the characteristic that a digital circuit is not easily influenced by the environment, the gyroscope angular rate can be accurately analyzed under the extreme environment. In addition, the signal-to-noise ratio of the device is improved.
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