摘要：【中文】本发明涉及一种降低AD患者脑内淀粉沉积斑块的药物。本发明提供了一种治疗阿尔兹海默症的多肽类药物，所述药物包括VGF蛋白的C端多肽片段TLQP‑21和医学上可用的载体，其氨基酸序列如SEQ ID NO：1或SEQ ID NO：2所示。本发明开发的多肽TLQP‑21具有降低阿尔兹海默症患者脑内的蛋白沉积斑块，增加小胶质细胞吞噬和迁移能力，提高神经元的功能，改善患者的病理发展进程。为治疗阿尔兹海默症提供一种新药。 【EN】The invention relates to a medicine for reducing starch deposition plaques in brains of AD patients. The invention provides a polypeptide drug for treating Alzheimer's disease, which comprises a C-terminal polypeptide fragment TLQP-21 of VGF protein and a medically available carrier, wherein the amino acid sequence of the polypeptide drug is shown as SEQ ID NO: 1 or SEQ ID NO: 2, respectively. The polypeptide TLQP-21 developed by the invention has the functions of reducing protein deposition plaques in the brain of a patient with Alzheimer's disease, increasing the phagocytosis and migration capability of microglia, improving the function of neurons and improving the pathological development process of the patient. Provides a new medicine for treating the Alzheimer disease.

摘要：【中文】用于选择用于免疫疗法的癌症患者的方法包括：从癌症患者的肿瘤确定总过客基因突变负荷，对于肿瘤的突变负荷生成背景分布，针对背景分布归一化总过客基因突变负荷，并且当总过客基因突变负荷大于背景分布平均值时，将癌症患者分类为免疫疗法响应者。当癌症患者是免疫疗法响应者时，可以向患者施用包含T细胞受体的活化/抑制的免疫治疗方案，其促进T细胞活化和/或延长免疫细胞溶解活性。 【EN】A method for selecting a cancer patient for immunotherapy comprises: determining a total passenger gene mutation burden from a tumor of a cancer patient, generating a background distribution for the mutation burden of the tumor, normalizing the total passenger gene mutation burden against the background distribution, and classifying the cancer patient as an immunotherapy responder when the total passenger gene mutation burden is greater than the background distribution mean. When the cancer patient is an immunotherapy responder, an immunotherapy regimen comprising activation/inhibition of T cell receptors, which promotes T cell activation and/or prolongs immune cytolytic activity, may be administered to the patient.

摘要：【中文】本发明实施例涉及电池管理中的故障检测，公开了一种故障诊断的优化方法及装置、电池管理系统和存储介质。该故障诊断的优化方法应用于电池管理系统BMS，包括：获取检测数据；根据检测数据确定电池管理系统处于失效状态；获取失效状态下的失效监测数据，根据所述失效监测数据判断故障是否真正发生，并获得判断结果；根据所述判断结果更新故障统计参数的数值；根据所述故障统计参数的数值优化故障诊断策略。本发明中，在失效发生时获取检测数据，使得故障检测更准确进而优化故障诊断的方法。 【EN】The embodiment of the invention relates to fault detection in battery management, and discloses a fault diagnosis optimization method and device, a battery management system and a storage medium. The optimization method for fault diagnosis is applied to a battery management system BMS and comprises the following steps: acquiring detection data; determining that the battery management system is in a failure state according to the detection data; acquiring failure monitoring data in a failure state, judging whether a fault really occurs according to the failure monitoring data, and acquiring a judgment result; updating the numerical value of the fault statistical parameter according to the judgment result; and optimizing a fault diagnosis strategy according to the numerical value of the fault statistical parameter. In the invention, the detection data is acquired when the failure occurs, so that the fault detection is more accurate and the fault diagnosis method is further optimized.

摘要：【中文】本发明公开一种ETC车载终端、ETC车载终端管理系统及其应用方法，该终端包括主控单元、NB‑IoT通信单元、第三耦合天线、卫星定位单元、RFID识别模块、LCD显示器。该系统包括上述的终端。本发明的方法采用上述的系统进行管理缴费。本发明基于车辆GPS定位和无线通信，同时能随时随地清楚车辆的位置，方便车辆管理，既可以进行车辆路旁停车和露天停车管理收费，又可以进行高速公路收费站不停车缴费管理。 【EN】The invention discloses an ETC vehicle-mounted terminal, an ETC vehicle-mounted terminal management system and an application method thereof. The system comprises the terminal. The method of the invention adopts the system to manage and pay. The invention is based on vehicle GPS positioning and wireless communication, can clear the position of the vehicle at any time and any place, is convenient for vehicle management, and can not only carry out vehicle roadside parking and open parking management charging, but also carry out non-stop payment management of a highway toll station.

摘要：【中文】本发明公开一类通式(1)所示的含氮多环化合物、包含该含氮多环化合物的高聚物、混合物、组合物及有机电子器件，其中，本发明的含氮多环化合物中，通过平面三苯胺和扭曲结构螺环结构稠合为核心单元，再与其他功能单元进行搭配，对分子结构和功能方面进行了调节，使其既具有较好的能量传输能力，又能实现较好的激子分散作用，从而有利于提高化合物及相关器件的性能。 【EN】The invention discloses a nitrogen-containing polycyclic compound shown in a general formula (1), a high polymer, a mixture, a composition and an organic electronic device containing the nitrogen-containing polycyclic compound,in the nitrogen-containing polycyclic compound, the planar triphenylamine and the twisted structure spiro structure are fused to form a core unit, and the core unit is matched with other functional units to adjust the molecular structure and function, so that the nitrogen-containing polycyclic compound has better energy transmission capability and can realize better exciton dispersion effect, thereby being beneficial to improving the performances of the compound and related devices.

摘要：【中文】本发明涉及一种变温环境下扭矩校准连接系统，包括加载端连接法兰、加载端传动轴、温控箱、被校扭矩传感器、平衡端传动轴、平衡端连接法兰；所述加载端连接法兰和平衡端连接法兰分别固定连接在加载端和平衡端上；所述加载端连接法兰与加载端传动轴固定连接，所述平衡端连接法兰与平衡端传动轴固定连接，所述加载端传动轴与平衡端传动轴之间固定连接被校扭矩传感器，并安置在温控箱中；所述加载端连接法兰与加载端传动轴之间固定连接加载端隔热垫圈和加载端隔热盘；所述平衡端连接法兰与平衡端传动轴之间固定连接平衡端隔热垫圈与平衡端隔热盘；所述加载端传动轴上固定加载端散热环，所述平衡端传动轴上固定连接平衡端散热环，从而实现变温环境下的扭矩校准。 【EN】The invention relates to a torque calibration connecting system in a variable temperature environment, which comprises a loading end connecting flange, a loading end transmission shaft, a temperature control box, a calibrated torque sensor, a balance end transmission shaft and a balance end connecting flange, wherein the loading end connecting flange is arranged on the loading end; the loading end connecting flange and the balance end connecting flange are fixedly connected to the loading end and the balance end respectively; the loading end connecting flange is fixedly connected with the loading end transmission shaft, the balance end connecting flange is fixedly connected with the balance end transmission shaft, and the loading end transmission shaft and the balance end transmission shaft are fixedly connected with a torque-corrected sensor and are arranged in the temperature control box; a loading end heat insulation gasket and a loading end heat insulation disc are fixedly connected between the loading end connecting flange and the loading end transmission shaft; a balance end heat insulation gasket and a balance end heat insulation disc are fixedly connected between the balance end connecting flange and the balance end transmission shaft; the loading end transmission shaft is fixedly provided with a loading end heat dissipation ring, and the balance end transmission shaft is fixedly connected with a balance end heat dissipation ring, so that torque calibration under a variable temperature environment is realized.

摘要：【中文】本发明涉及一种基于挠性支承的推力扭矩复合校准隔离结构，标准扭矩传感器一端连接驱动机构，另一端通过波纹管连接动力仪轴，所述标准扭矩传感器通过波纹管实现与动力仪主轴的推力部分计量级隔离，使动力仪主轴推力无法传递到标准扭矩传感器，并由驱动机构带动标准扭矩传感器、波纹管及动力仪主轴旋转，使标准扭矩传感器输出扭矩值，对动力仪轴系扭矩进行校准；所述动力仪主轴上通过两个安装在轴套内的高精度轴承与两个挠性支承连接，轴套下端通过传力杆连接标准推力传感器，由挠性支承座结合高精度轴承，将动力仪主轴的扭矩与推力校准部分隔离，从而实现计量级隔离，并由标准推力传感器输出数据对动力仪主轴轴向力进行校准。 【EN】The invention relates to a thrust and torque composite calibration isolation structure based on a flexible support.A standard torque sensor is connected with a driving mechanism at one end and is connected with a power instrument shaft at the other end through a corrugated pipe, the standard torque sensor realizes the measurement level isolation with the thrust part of a power instrument main shaft through the corrugated pipe, so that the thrust of the power instrument main shaft cannot be transmitted to the standard torque sensor, the driving mechanism drives the standard torque sensor, the corrugated pipe and the power instrument main shaft to rotate, the standard torque sensor outputs a torque value, and the torque of a power instrument shaft system is calibrated; the power meter main shaft is connected with the two flexible supports through the two high-precision bearings arranged in the shaft sleeve, the lower end of the shaft sleeve is connected with the standard thrust sensor through the dowel bar, the flexible support seat is combined with the high-precision bearings to isolate the torque and the thrust calibration part of the power meter main shaft, so that the metering magnitude isolation is realized, and the standard thrust sensor outputs data to calibrate the axial force of the power meter main shaft.

摘要：【中文】本发明涉及一种含硅螺环结构的化合物及其应用，该化合物具有如式(1)所示的结构通式。该化合物稳定性好、发光效率高、寿命长、合成简单。 【EN】The invention relates to a compound containing a silicon spiro structure and application thereof, wherein the compound has a structural general formula shown as a formula (1). The compound has good stability, high luminous efficiency, long service life and simple synthesis.

摘要：【中文】本发明属于化妆品组合物技术领域的一种组合物，尤其涉及一种新的抗痘组合物及其在化妆品中的应用。本发明公开的抗痘组合物包括组分赤松叶提取物、乳酸杆菌发酵产物。本发明的抗痘组合物基于群体效应，其优点是保持微生物群落平衡的同时进行治疗。安全无毒，抗痘效果显著。 【EN】The invention belongs to a composition in the technical field of cosmetic compositions, and particularly relates to a novel anti-acne composition and application thereof in cosmetics. The anti-acne composition disclosed by the invention comprises components of a red pine leaf extract and a lactobacillus fermentation product. The anti-acne composition of the present invention is based on a group effect, and has the advantage of treatment while maintaining the balance of microbial communities. Safe and nontoxic, and has remarkable anti-acne effect.

摘要：【中文】本发明关于一种环保人工皮革及其制造方法。该环保人工皮革的制造方法包括：熔喷一第一纤维网；设置一长纤维织物于所述第一纤维网上；熔喷一第二纤维网于所述长纤维织物上，以形成一多层纤维结构物；及热压所述多层纤维结构物，以制得环保人工皮革。 【EN】The invention relates to an environment-friendly artificial leather and a manufacturing method thereof. The manufacturing method of the environment-friendly artificial leather comprises the following steps: melt-blowing a first web; placing a long fiber fabric on the first web; melt-blowing a second web onto the long fiber fabric to form a multi-layer fiber structure; and hot-pressing the multilayer fiber structure to obtain the environment-friendly artificial leather.