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申请号:201880067863.7 公开号:CN111225916A 主分类号:C07D471/04
申请人:【中文】加拉帕戈斯股份有限公司【EN】GALAPAGOS N.V. 申请日:2018.10.11 公开日:2020.06.02
摘要:【中文】本发明公开了式I的化合物:其中R1、L1、R2、L2、R3、Cy及下标n如本文所定义。本发明涉及化合物、用于其制备的方法、包含其的药物组合物及使用其的治疗方法,通过施用本发明的化合物用于预防和/或治疗过敏性疾病、炎性疾病、代谢疾病、自身炎性疾病、自身免疫疾病、增殖性疾病、移植排斥、涉及软骨转换障碍的疾病、先天性软骨畸形和/或与IFNα、IL12和/或IL23分泌过多相关的疾病。 【EN】The present invention discloses compounds of formula I:wherein R is1、L1、R2、L2、R3Cy and subscript n are as defined herein. The present invention relates to compounds for preventing and/or treating allergic diseases, inflammatory diseases, metabolic diseases, autoinflammatory diseases, and the like, by administering the compounds, methods for preparing the same, pharmaceutical compositions comprising the same, and methods of treatment using the samediseases, autoimmune diseases, proliferative diseases, transplant rejection, diseases involving cartilage turnover disorders, congenital cartilage malformations, and/or diseases associated with hypersecretion of IFN α, IL12, and/or IL 23.
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