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申请号:201911214112.6 公开号:CN110850834A 主分类号:G05B19/418
申请人:【中文】合肥工业大学【EN】Hefei University of Technology 申请日:2019.12.02 公开日:2020.02.28
摘要:【中文】本发明公开一种并联机器人的建模方法、建模系统、控制方法及控制系统,其中,所述并联机器人的建模方法包括建立并联机器人的无约束系统模型;将物理约束转换为特定数据形式引入,以获取满足给定物理约束的约束力解析数据;以及将所述约束力解析数据附加到所述无约束系统模型中,以获取所述并联机器人的动力学模型。利用本发明建立的动力学模型中约束力是解析解的表达式,并且建模的过程步骤清晰简洁,具有普遍性、系统性和简单性,而且经过仿真模拟分析,该通过该方法建立的动力学模型具有有效性和准确性。 【EN】The invention discloses a modeling method, a modeling system, a control method and a control system of a parallel robot, wherein the modeling method of the parallel robot comprises the steps of establishing an unconstrained system model of the parallel robot; converting the physical constraints into a specific data form and introducing the specific data form to obtain constraint force analysis data meeting the given physical constraints; and adding the constraint force analysis data to the unconstrained system model to obtain a dynamic model of the parallel robot. The constraint force in the dynamic model established by the method is an expression of an analytic solution, the steps of the modeling process are clear and concise, and the method has universality, systematicness and simplicity, and the dynamic model established by the method has effectiveness and accuracy through simulation analysis.
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申请号:201911130081.6 公开号:CN111017513A 主分类号:B65G45/12
摘要:【中文】本发明公开了一种回程皮带清洗装置,包括顶部为开口设置的矩形箱,所述矩形箱的顶部内壁为倾斜面,所述矩形箱的底部内壁上开设有出料孔,所述矩形箱的四侧内壁上粘接固定有同一个弹性矩形胶圈,且弹性矩形胶圈的顶部延伸至矩形箱的上方,所述矩形箱的后侧内壁上固定连接有喷水管,且喷水管的顶部内壁上开设有多个喷水孔,所述矩形箱的前侧螺纹固定有水泵,喷水管的一端延伸至矩形箱外并与水泵的出水口连通并固定。本发明设计合理,使用方便,通过冲洗和两个刮除的方式,便于自动稳定的对回程皮带进行清理,避免带煤现象,配合弹性矩形胶圈的设置能够避免清理中水冲出,满足使用需求,有利于使用。 【EN】The invention discloses a return belt cleaning device which comprises a rectangular box with an opening at the top, wherein the inner wall of the top of the rectangular box is an inclined plane, the inner wall of the bottom of the rectangular box is provided with a discharge hole, the inner walls of four sides of the rectangular box are fixedly bonded with the same elastic rectangular rubber ring, the top of the elastic rectangular rubber ring extends to the upper part of the rectangular box, the inner wall of the rear side of the rectangular box is fixedly connected with a water spray pipe, the inner wall of the top of the water spray pipe is provided with a plurality of water spray holes, the front side of the rectangular box is fixedly provided with a water pump in a threaded manner, and one end of the water spray pipe extends out of the rectangular box and is communicated and fixed with a water outlet of the. The cleaning device is reasonable in design and convenient to use, automatically and stably cleans a return belt conveniently in a flushing and two scraping mode, the coal carrying phenomenon is avoided, water in cleaning can be prevented from being flushed out by matching with the elastic rectangular rubber ring, the use requirement is met, and the cleaning device is beneficial to use.
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申请号:201811442182.2 公开号:CN111228406A 主分类号:A61K36/8984
摘要:【中文】本发明公开了一种治疗慢性萎缩性胃炎的药物及制备方法,属于中药技术领域。所涉及的药物由石斛、知母、黄连、苦参、茯苓、白术、黄芪、白及、马齿苋、枳壳、威灵仙、地榆、射干、连翘十四味药材组成,取白术、枳壳、连翘提取挥发油,药渣与其余茯苓等十一味水提,滤过,滤液与蒸馏后水溶液合并浓缩后加适量辅料一步制粒,加入白术等挥发油混匀,即得。用于治疗慢性萎缩性胃炎属郁热蕴胃,伤及气阴证。经药效学及临床评价,证实通过上述方法制备的药物治疗慢性萎缩性胃炎安全且疗效确切。而且该中药复方制法简单,易于规模化生产。 【EN】The invention discloses a medicine for treating chronic atrophic gastritis and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. The related medicine is prepared from fourteen medicinal materials of dendrobium, rhizoma anemarrhenae, coptis chinensis, radix sophorae flavescentis, poria cocos, bighead atractylodes rhizome, astragalus mongholicus, rhizoma bletillae, purslane, fructus aurantii, radix clematidis, garden burnet, blackberry lily and fructus forsythiae, volatile oil is extracted from the bighead atractylodes rhizome, the fructus aurantii and the fructus forsythiae, dregs of a decoction and the rest eleven medicinal materials of the poria cocos and the like are extracted by water, the filtrate and the distilled water solution are mixed and concentrated, then a proper amount of auxiliary materials. Can be used for treating chronic atrophic gastritis with syndrome of stagnated heat in stomach and impairment of qi and yin. Pharmacodynamics and clinical evaluation prove that the medicine prepared by the method is safe and has definite curative effect on the chronic atrophic gastritis. And the preparation method of the traditional Chinese medicine compound is simple and is easy for large-scale production.
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申请号:201911381699.X 公开号:CN111121083A 主分类号:F23M5/00
申请人:【中文】合肥恒力装备有限公司【EN】HENGLI ELETEK Co.,Ltd. 申请日:2019.12.27 公开日:2020.05.08
摘要:【中文】本发明公开了一种活性炭材料连续炭化推板炉的炉膛制作方法,包括炉膛,所述炉膛的内底壁对称固定连接有两个侧滑条轨道,所述炉膛的内顶壁还固定连接有多个底滑条轨道,且多个底滑条轨道设置在两个侧滑条轨道内,所述炉膛内设有推板,且推板贴合在多个底滑条轨道与两个侧滑条轨道的上方,所述炉膛的外侧壁上开设有多个安装孔,其中两个相邻的所述安装孔内分别安装有热电偶与氧含量检测管。优点在于:炉膛采用重质材料砌筑为圆弧拱顶结构,加热元件使用保护管保护,避免物料烧结产生的焦油及废气以及碳粉腐蚀及侵蚀陶瓷纤维保温材料及加热元件。 【EN】The invention discloses a hearth manufacturing method of an active carbon material continuous carbonization push plate furnace, which comprises a hearth, wherein two side slide bar tracks are symmetrically and fixedly connected to the inner bottom wall of the hearth, a plurality of bottom slide bar tracks are also fixedly connected to the inner top wall of the hearth, the bottom slide bar tracks are arranged in the two side slide bar tracks, a push plate is arranged in the hearth and is attached above the bottom slide bar tracks and the two side slide bar tracks, a plurality of mounting holes are formed in the outer side wall of the hearth, and a thermocouple and an oxygen content detection tube are respectively mounted in two adjacent mounting holes. Has the advantages that: the hearth is built by heavy materials into an arc vault structure, and the heating element is protected by a protective pipe, so that tar and waste gas generated by material sintering and carbon powder are prevented from corroding and eroding ceramic fiber heat-insulating materials and the heating element.
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申请号:201911123985.6 公开号:CN110867230A 主分类号:G16H10/60
摘要:【中文】本发明涉了血液透析综合管理,具体为一种血透室智能化信息识别及管理系统,其特征在于:包括患者信息收录、中央数据处理系统、APP系统、医护人员使用系统、患者及家属查询系统,所述患者信息收录接珍综合信息录入中央数据处理系统,所述的中央数据处理系统有公知数据服务器提供服务,所述APP系统属手机程序软件提供服务,分别设置医护人员、患者及家属使用权限APP系统,所述的医护人员使用系统,分别设置PC机的医护人员不同工作内容的相对应的使用权限,所述的患者及家属查询系统,分别设置对应患者及家属相对应的使用权限,通过综合设置并数据分析采集,实现了质量管理控制系统的数据收集的流程完善,保障患者治疗过程中的安全系数。 【EN】The invention relates to hemodialysis integrated management, in particular to an intelligent hemodialysis room information identification and management system, which is characterized in that: including patient information collection, central data processing system, APP system, medical personnel use system, patient and family members inquiry system, patient information collection connects precious comprehensive information to enter central data processing system, central data processing system have well-known data server to provide service, APP system belongs to cell-phone program software and provides service, sets up medical personnel, patient and family members respectively and uses the authority APP system, medical personnel use system, set up the corresponding permission of the different work content of medical personnel of PC respectively, patient and family members inquiry system, set up corresponding patient and the corresponding permission of family members respectively, through comprehensive setting and data analysis collection, the flow that has realized quality management control system's data collection is perfect, ensures the factor of safety of patient's treatment in-process.
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申请号:201911082989.4 公开号:CN110882515A 主分类号:A62D3/02
申请人:【中文】桂林理工大学【EN】Guilin University of Technology 申请日:2019.11.07 公开日:2020.03.17
摘要:【中文】本发明公开了一种使用乙酰丁香酮提高漆酶降解己烯雌酚降解率的方法及应用,属于环境污染处理技术领域,具体为先将乙酰丁香酮和漆酶组成乙酰丁香酮‑漆酶介质缓冲溶液,然后与已烯雌酚溶液混合,在震荡培养箱中反应至结束后利用乙酸乙酯淬灭反应,从而实现对己烯雌酚的降解。本发明利用乙酰丁香酮作为氧化还原介质,使其作为漆酶和底物之间的电子穿梭,从而克服漆酶的空间位阻,使漆酶能够更好地实现与己烯雌酚结合,显著提高漆酶的降解效率。同时,本发明的操作方法简单、高效,在环境污染处理中具有极高的应用价值。 【EN】The invention discloses a method for improving the degradation rate of diethylstilbestrol degraded by laccase and application thereof, belonging to the technical field of environmental pollution treatment. According to the invention, acetosyringone is used as an oxidation-reduction medium and is used as an electron shuttle between laccase and a substrate, so that the steric hindrance of laccase is overcome, the laccase can be better combined with diethylstilbestrol, and the degradation efficiency of the laccase is remarkably improved. Meanwhile, the operation method is simple and efficient, and has extremely high application value in environmental pollution treatment.
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申请号:201911120073.3 公开号:CN110909214A 主分类号:G06F16/903
摘要:【中文】本发明公开了基于KMP匹配算法的字符串快速匹配方法,涉及数据处理技术领域。本发明包括将模式串最后一个字符x与文本串进行匹配;若字符x匹配失败;采用坏字符规则移动;若字符x匹配时;采用模式串前缀与文本串比较,若模式串前缀与文本串同配,则字符串找到;若失配,则根据KMP算法得到模式串右移的距离使模式串在新位置进行一下轮的匹配。本发明通过将模式串最后一个字符x与文本串进行匹配;若字符x匹配失败;采用坏字符规则移动;若字符x匹配时;采用模式串前缀与文本串比较;降低字符匹配时间复杂度,提高匹配效率。 【EN】The invention discloses a KMP (K Markov model) matching algorithm-based character string fast matching method, and relates to the technical field of data processing. Matching the last character x of the pattern string with the text string; if the character x fails to match; moving regularly by adopting bad characters; if the character x matches; comparing the mode string prefix with the text string, and if the mode string prefix is matched with the text string, finding the character string; and if the pattern string is mismatched, obtaining the distance of right shift of the pattern string according to the KMP algorithm so as to enable the pattern string to be matched at a new position for the next round. The method matches the last character x of the pattern string with the text string; if the character x fails to match; moving regularly by adopting bad characters; if the character x matches; comparing the mode string prefix with the text string; the complexity of character matching time is reduced, and the matching efficiency is improved.
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申请号:201911282242.3 公开号:CN110974953A 主分类号:A61K39/39
摘要:【中文】本发明公开了一种免疫佐剂,所述免疫佐剂包含选自盐类壳聚糖溶液、季铵化壳聚糖溶液或羟基化壳聚糖溶液中的一种或几种;其中,所述盐类壳聚糖溶液的pH值为4.5~5.5,所述季铵化壳聚糖溶液的pH值为5.8~8,所述羟基化壳聚糖溶液的pH值为5.8~8。本发明筛选出的特定壳聚糖衍生物能够增强不同抗原体液免疫应答及黏膜免疫应答反应,具有良好的佐剂作用,为壳聚糖衍生物佐剂作用机理的研究奠定基础,有望替代壳聚糖用于黏膜佐剂的开发。 【EN】The invention discloses an immunologic adjuvant which comprises one or more selected from salt chitosan solution, quaternized chitosan solution or hydroxylated chitosan solution; the pH value of the salt chitosan solution is 4.5-5.5, the pH value of the quaternized chitosan solution is 5.8-8, and the pH value of the hydroxylated chitosan solution is 5.8-8. The specific chitosan derivative screened by the invention can enhance humoral immune response and mucosal immune response reaction of different antigens, has good adjuvant effect, lays a foundation for the research of the action mechanism of the chitosan derivative adjuvant, and is expected to replace chitosan to be used for the development of mucosal adjuvants.
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申请号:201811125906.0 公开号:CN110950965A 主分类号:C07K19/00
摘要:【中文】本发明属于基因工程领域,具体涉及一种抗人CD123的嵌合抗原受体及其应用。本发明的识别CD123抗原的多肽包含如SEQ ID NO:4‑7所示的氨基酸序列,其作为(chimeric antigen receptor,CAR)结构中抗原识别区均能诱导CAR‑T细胞活化。抗CD123抗原的嵌合抗原受体在免疫细胞中表达后,不仅可以有效的清除表达CD123抗原的肿瘤靶细胞,而对阴性抗原(不表达CD123)的肿瘤细胞没有毒性作用;并且能够维持靶向CD123的CAR在病人细胞培养过程中的阳性率,在靶抗原刺激后能够长时间的进行增殖,能够用于肿瘤的靶向治疗。 【EN】The invention belongs to the field of genetic engineering, and particularly relates to an anti-human CD123 chimeric antigen receptor and application thereof. The polypeptide for recognizing the CD123 antigen comprises amino acid sequences shown as SEQ ID NO:4-7, and can be used as an antigen recognition region in a (CAR) structure to induce CAR-T cell activation. After the chimeric antigen receptor of the anti-CD 123 antigen is expressed in immune cells, not only can the tumor target cells expressing the CD123 antigen be effectively eliminated, but also the tumor target cells of negative antigen (not expressing CD123) have no toxic effect; and the CD 123-targeted CAR can maintain the positive rate in the cell culture process of a patient, can proliferate for a long time after being stimulated by a target antigen, and can be used for the targeted therapy of tumors.
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申请号:201811125919.8 公开号:CN110950954A 主分类号:C07K16/28
摘要:【中文】本发明属于基因工程领域,具体涉及一种抗CD123人源化单链抗体及其应用。本发明的识别CD123抗原的单链抗体的轻链氨基酸序列如SEQ ID NO:1,SEQ ID NO:3,SEQ ID NO:5,SEQ ID NO:7所示,所述单链抗体的重链氨基酸序列如SEQ ID NO:2,SEQ ID NO:4,SEQ ID NO:6,SEQ ID NO:8所示。本发明提供了稳定适合的抗CD123人源化单链抗体(scFv),其用于制备CAR结构,既保留了scFv的结合特异性和亲和力,又保证了CAR‑T在体内的的稳定性和安全性。在免疫细胞中表达后,不仅可以有效的清除表达CD123抗原的肿瘤靶细胞,而对阴性抗原(不表达CD123)的肿瘤细胞没有毒性作用;并且能够维持靶向CD123的CAR在病人细胞培养过程中的阳性率,在靶抗原刺激后能够长时间的进行增殖,能够用于肿瘤的靶向治疗。 【EN】The invention belongs to the field of genetic engineering, and particularly relates to an anti-CD 123 humanized single-chain antibody and application thereof. The light chain amino acid sequence of the single-chain antibody for identifying the CD123 antigen is shown as SEQ ID NO.1, SEQ ID NO. 3, SEQ ID NO. 5 and SEQ ID NO. 7, and the heavy chain amino acid sequence of the single-chain antibody is shown as SEQ ID NO. 2, SEQ ID NO. 4, SEQ ID NO. 6 and SEQ ID NO. 8. The invention provides a stable and suitable anti-CD 123 humanized single-chain antibody (scFv) for preparing a CAR structure, which not only retains the binding specificity and affinity of the scFv, but also ensures the stability and safety of CAR-T in vivo. After the expression in immune cells, the tumor target cells expressing the CD123 antigen can be effectively eliminated, and the tumor cells which do not express the CD123 antigen have toxic effect; and the CD 123-targeted CAR can maintain the positive rate in the cell culture process of a patient, can proliferate for a long time after being stimulated by a target antigen, and can be used for the targeted therapy of tumors.
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