摘要：【中文】本发明公开了一种检测肺动脉高压病的ALK1基因探针组，所述基因探针组是用于检测激活素受体样激酶1(ALK1)基因突变的基因探针组合物，所述基因探针组合物由265条探针组成，本发明还公开了上述ALK1基因探针组在制备肺动脉高压病的诊断试剂盒方面的应用以及利用上述ALK1基因探针组进行的非疾病诊断治疗目的的肺动脉高压病的基因突变体外检测方法。 【EN】The invention discloses an ALK1 gene probe set for detecting pulmonary hypertension, which is a gene probe composition for detecting gene mutation of activin receptor-like kinase 1(ALK1), wherein the gene probe composition consists of 265 probes, the invention also discloses application of the ALK1 gene probe set in preparing a diagnostic kit for pulmonary hypertension and an in-vitro detection method for the gene mutation of pulmonary hypertension for non-disease diagnosis and treatment purposes by using the ALK1 gene probe set.

摘要：【中文】本发明公开了一种检测肺动脉高压病的KCNK3基因探针组，所述基因探针组是用于检测内向整流钾离子通道3(potassium channel subfamily K member 3，KCNK3)基因突变的基因探针组合物，所述基因探针组合物由175条探针组成，本发明还公开了上述KCNK3基因探针组在制备肺动脉高压病的诊断试剂盒方面的应用以及利用上述KCNK3基因探针组进行的非疾病诊断治疗目的的肺动脉高压病的基因突变体外检测方法。 【EN】The invention discloses a KCNK3 gene probe set for detecting pulmonary hypertension, which is a gene probe composition for detecting gene mutation of inward rectifying potassium ion channel 3(KCNK3), wherein the gene probe composition consists of 175 probes, the invention also discloses an application of the KCNK3 gene probe set in the preparation of a diagnostic kit for pulmonary hypertension and an in-vitro detection method for the gene mutation of the pulmonary hypertension for non-disease diagnosis and treatment purposes by using the KCNK3 gene probe set.

摘要：【中文】本发明公开了一种检测肺动脉高压病的ENG基因探针组，所述基因探针组是用于检测内皮因子(Endoglin，ENG)基因突变的基因探针组合物，所述基因探针组合物由324条探针组成，本发明还公开了上述ENG基因探针组在制备肺动脉高压病的诊断试剂盒方面的应用以及利用上述ENG基因探针组进行的非疾病诊断治疗目的的肺动脉高压病的基因突变体外检测方法。 【EN】The invention discloses an ENG gene probe group for detecting pulmonary hypertension, which is a gene probe composition for detecting endothelial factor (Endoglin, ENG) gene mutation, and the gene probe composition consists of 324 probes.

摘要：【中文】本发明公开了一种检测肺动脉高压病的SMAD9基因探针组，所述基因探针组是用于检测母亲抗十肽同系物9(Mothers against decapentaplegic homolog 9，SMAD9)基因突变的基因探针组合物，所述基因探针组合物由202条探针组成，本发明还公开了上述SMAD9基因探针组在制备肺动脉高压病的诊断试剂盒方面的应用以及利用上述SMAD9基因探针组进行的非疾病诊断治疗目的的肺动脉高压病的基因突变体外检测方法。 【EN】The invention discloses an SMAD9 gene probe set for detecting pulmonary hypertension, which is a gene probe composition for detecting maternal decapeptide homolog 9(SMAD9) gene mutation, wherein the gene probe composition consists of 202 probes, the invention also discloses an application of the SMAD9 gene probe set in preparing a diagnostic kit for pulmonary hypertension and an in-vitro detection method for the gene mutation of the pulmonary hypertension for non-disease diagnosis and treatment purposes by using the SMAD9 gene probe set.

摘要：【中文】本发明公开了一种检测肺动脉高压病的BMPR2基因探针组，所述基因探针组是用于检测骨形成蛋白Ⅱ型受体(Bone morphogenetic protein receptor 2，BMPR2)基因突变的基因探针组合物，所述基因探针组合物由164条探针组成，本发明还公开了上述BMPR2基因探针组在制备肺动脉高压病的诊断试剂盒方面的应用以及利用上述BMPR2基因探针组进行的非疾病诊断治疗目的的肺动脉高压病的基因突变体外检测方法。 【EN】The invention discloses a BMPR2 gene probe set for detecting pulmonary hypertension, which is a gene probe composition for detecting Bone morphogenetic protein II receptor (BMPR2) gene mutation, wherein the gene probe composition consists of 164 probes, the invention also discloses an application of the BMPR2 gene probe set in the aspect of preparing a diagnostic kit for pulmonary hypertension and an in-vitro detection method for the gene mutation of the pulmonary hypertension for non-disease diagnosis and treatment purposes by using the BMPR2 gene probe set.

摘要：【中文】本发明公开了一种改良CIK细胞培养基及其使用方法，包括下列原料制成：FBS100～200ml/L；谷氨酰胺1～2mmol/L；青霉素100μg/L；链霉素100μg/L；HEPES20～100mmol/L；丙酮酸钠8～15mmol/L；β‑巯基乙醇20～50μmol/L；适量核苷酸与脱氧核苷酸，本发明改良CIK培养基培养的CIK细胞增殖好、纯度高、细胞毒性极强，有明显的肿瘤细胞杀伤效应；本发明改良了传统CIK培养基的配方，并验证其抗瘤活性及安全性，能清除CIK细胞免疫治疗领域的一个重要障碍，为CIK细胞用作自体细胞治疗产品服务临床提供重要的理论支持。 【EN】The invention discloses an improved CIK cell culture medium and a using method thereof, and the improved CIK cell culture medium is prepared from the following raw materials of 100-200 ml/L of FBS, 1-2 mmol/L of glutamine, 100 mu g/L of penicillin, 100 mu g/L of streptomycin, 20-100 mmol/L of HEPES, 8-15 mmol/L of sodium pyruvate, 20-50 mu mol/L of β -mercaptoethanol, and appropriate amount of nucleotide and deoxynucleotide.

摘要：【中文】本发明实施例提供一种异常线路分析方法、装置及电子设备，其中，方法包括：获取物流对象的实际履行线路数据；获取所述物流对象对应的标准规划线路数据；将所述物流对象的实际履行线路数据与标准规划线路数据进行比对，获取所述物流对象的错分详情数据。本发明实施例的方案，能够对中的异常线路进行准确评价，并可实时对线路上快递车辆的实际履行线路进行异常监控和预判。 【EN】The embodiment of the invention provides an abnormal line analysis method, an abnormal line analysis device and electronic equipment, wherein the method comprises the following steps: acquiring actual fulfillment line data of the logistics object; acquiring standard planning line data corresponding to the logistics object; and comparing the actual fulfillment line data of the logistics object with standard planning line data to obtain the wrong score detail data of the logistics object. According to the scheme of the embodiment of the invention, the centered abnormal line can be accurately evaluated, and the actual fulfillment line of the express delivery vehicle on the line can be monitored and prejudged in real time.

摘要：【中文】本发明涉及夹具技术领域，尤其涉及一种自动化焊接夹具快换使用的横梁电动换模车，由电动叉车和换模机构组成。上述换模机构由左右滑移机构、导向机构、前后滑移机构、曲轴机构、夹具挂钩机构、推拉机构、曲轴限位机构、横梁挂钩机构装配构成。本横梁电动换模车，整体小巧，适合在工厂快速方便移动。通过四连杆机构的组合切换，针对不同质量差异和形状复杂程度不同的夹具进行更换，可以降低劳动强度，同时换模的安全隐患同样大幅度降低，效率相对传统换模大幅度提高，制作工艺简单，制造成本低廉，调整方便。因此可以说它具备了多种优点，特别适合于在本领域中推广应用，其市场前景十分广阔。 【EN】The invention relates to the technical field of clamps, in particular to a beam electric die changing vehicle for quickly changing an automatic welding clamp. The die changing mechanism is formed by assembling a left sliding mechanism, a right sliding mechanism, a guide mechanism, a front sliding mechanism, a rear sliding mechanism, a crankshaft mechanism, a clamp hook mechanism, a push-pull mechanism, a crankshaft limiting mechanism and a beam hook mechanism. This electronic retooling car of crossbeam, whole small and exquisite is fit for the quick convenient removal in mill. Through the combination switching of four-bar linkage, change to the anchor clamps that different quality difference and shape complexity are different, can reduce intensity of labour, the potential safety hazard of retooling simultaneously reduces by a wide margin equally, and efficiency is improved by a wide margin compared with traditional retooling, and preparation simple process, low in manufacturing cost is honest and clean, and the adjustment is convenient. Therefore, the method has multiple advantages, is particularly suitable for popularization and application in the field, and has very wide market prospect.

摘要：【中文】本发明提供一种多聚焦多源图像融合方法，对具有M个聚焦点的源图像进行分解融合叠加处理，将源图像分解成基部和细节，采用双数复小波算法对所述基部进行滤波去噪获得融合基部，采用预训练模型VGG‑S对细节进行深度特征提取获得细节特征，并采用多层融合策略重构细节特征，接着对所述细节特征选取梯度极大值获得融合细节，最后将获得的融合基部和融合细节进行叠合，完成图像融合。该方法获得的融合图像不仅保留了融合前图像的特征信息，提高了图像有效信息的利用率，同时清晰度也更高，更加细节化，全面化，优质化。该方法应用范围更为广阔，可以在日常生活，医学，军事等方面提供更多图像信息。 【EN】The invention provides a multi-focus multi-source image fusion method, which comprises the steps of decomposing, fusing and overlapping a source image with M focus points, decomposing the source image into a base part and details, carrying out filtering and denoising on the base part by adopting an even-number complex wavelet algorithm to obtain a fusion base part, carrying out depth feature extraction on the details by adopting a pre-training model VGG-S to obtain detail features, reconstructing the detail features by adopting a multi-layer fusion strategy, selecting gradient maximum values for the detail features to obtain fusion details, and finally overlapping the obtained fusion base part and the fusion details to complete image fusion. The fused image obtained by the method not only retains the characteristic information of the image before fusion, improves the utilization rate of effective information of the image, but also has higher definition, more detail, comprehensiveness and quality. The method has wider application range and can provide more image information in the aspects of daily life, medicine, military and the like.

摘要：【中文】本发明涉及一种密封玻璃钢管道，包括第一管道、第二管道；所述第一管道的一端为承口，所述第二管道的一端为插入所述承口内的插口；位于所述承口内壁与所述插口外壁间隙处设置有密封件，所述密封件内壁与所述插口外壁贴合；顶杆与所述密封件后端面相抵，所述顶杆通过螺纹与连接板连接，所述连接板固定在所述承口端面处；当转动所述顶杆，所述顶杆驱动所述密封件沿所述第二管道轴线方向移动，并将所述密封件外壁贴合所述承口内壁；通过顶杆的转动实现顶杆的平移，从而与密封件后端面相抵，实现密封件沿第二管道轴线方向的运动，使得密封件贴合承口内壁与插口外壁，实现管道连接处的密封。 【EN】The invention relates to a sealed glass fiber reinforced plastic pipeline, which comprises a first pipeline and a second pipeline; one end of the first pipeline is a socket, and one end of the second pipeline is a socket inserted into the socket; a sealing element is arranged at the gap between the inner wall of the socket and the outer wall of the socket, and the inner wall of the sealing element is attached to the outer wall of the socket; the ejector rod abuts against the rear end face of the sealing element, the ejector rod is connected with a connecting plate through threads, and the connecting plate is fixed at the end face of the socket; when the ejector rod is rotated, the ejector rod drives the sealing element to move along the axis direction of the second pipeline, and the outer wall of the sealing element is attached to the inner wall of the socket; the ejector rod is translated through rotation of the ejector rod, so that the ejector rod is abutted to the rear end face of the sealing element, the sealing element moves along the axis direction of the second pipeline, the sealing element is attached to the inner wall of the socket and the outer wall of the socket, and sealing of the joint of the pipeline is achieved.