摘要：【中文】本发明属于医用抗菌剂技术领域，具体涉及一种环保型防霉抗菌剂。一种环保型防霉抗菌剂，按重量份计，包括如下组分：吡啶硫酮锌10‑30份、噻唑类抗菌剂5‑10份、分散剂0.5‑2份、增稠剂0.2‑1份、消泡剂0.1‑0.5份、乳化剂0.2‑1份、溶剂55‑70份。本发明所制备得到的环保型防霉抗菌剂采用吡啶硫酮锌和噻唑类抗菌剂复配后，可以起到即抗菌又有防霉的双重功效，同时本产品溶剂是水，更加环保无毒，是一种环保型防霉抗菌剂，而且具有极强的灭杀微生物能力，杀菌范围广，对细菌、真菌、酵母菌均有良好的灭杀效果。 【EN】The invention belongs to the technical field of medical antibacterial agents, and particularly relates to an environment-friendly mildew-proof antibacterial agent. An environment-friendly mildew-proof antibacterial agent comprises the following components in parts by weight: 10-30 parts of zinc pyrithione, 5-10 parts of thiazole antibacterial agent, 0.5-2 parts of dispersant, 0.2-1 part of thickener, 0.1-0.5 part of defoamer, 0.2-1 part of emulsifier and 55-70 parts of solvent. The environment-friendly mildew-proof antibacterial agent prepared by the invention has double effects of antibiosis and mildew prevention after being compounded by zinc pyrithione and thiazole antibacterial agents, and meanwhile, the solvent of the product is water, so that the environment-friendly mildew-proof antibacterial agent is more environment-friendly and nontoxic, has extremely strong killing and killing capability, wide sterilization range and good killing effect on bacteria, fungi and yeasts.

摘要：【中文】本发明提供了一种高危型HPV型别和宫颈癌前病变阶段间关系的计算方法和装置，该方法包括：对通过薄层细胞学检查(TCT)和HPV基因分型检测得到的M种宫颈癌前病变阶段下的N种高危型HPV感染数据进行分类整理，获得不同感染方式下的HPV感染预处理数据；基于HPV预处理数据作聚类分析，并基于聚类分析结果获取不同高危型HPV的相似性；基于所述的单重感染和多重感染方式下的HPV预处理数据按泊松分布建模，进行回归分析，获取HPV单重感染和多重感染对宫颈癌前病变的影响比重。该方法结合聚类技术、统计分析方法，对生物数据进行挖掘，发现不同高危型HPV与不同宫颈癌前病变阶段间的关系。 【EN】The invention provides a method and a device for calculating the relationship between high-risk HPV types and lesion stages before cervical cancer, wherein the method comprises the following steps: classifying and sorting N high-risk HPV infection data under M cervical carcinoma pre-lesion stages obtained by thin-layer cytology examination (TCT) and HPV genotyping detection to obtain HPV infection pretreatment data under different infection modes; performing clustering analysis based on the HPV preprocessing data, and acquiring the similarity of different high-risk HPV based on the clustering analysis result; and modeling according to Poisson distribution based on HPV pretreatment data in the single infection and multiple infection modes, and performing regression analysis to obtain the influence proportion of the single infection and multiple infection of HPV on the cervical precancerous lesion. The method is combined with a clustering technology and a statistical analysis method to mine biological data and discover the relationship between different high-risk HPV and different cervical carcinoma pre-lesion stages.

摘要：【中文】本发明涉及一种用于生产1,1,1‑三氟‑2‑氯乙烷(HCFC‑133a)和/或三氟乙胺(TFEA)的方法，其中至少一个反应步骤在微反应器中进行。特别地，本发明的优选实施例涉及一种用于生产1,1,1‑三氟‑2‑氯乙烷(HCFC‑133a)和/或三氟乙胺(TFEA)的方法，其中至少一个反应步骤在由SiC构成或制成的微反应器(“SiC微反应器”)中或者在由合金(例如Hastelloy C)构成或制成的微反应器中进行。在制造HCFC‑133a和/或TFEA时，HCFC‑133a和/或TEFA可通过(例如)仅使用低能耗的方法容易地进行纯化和/或分离，并且进行纯化和/或分离的方法优选不需要蒸馏。有利地，通过相分离可以容易地以节能方式从过量的HF和催化剂中分离出HCFC‑133a和/或TEFA。 【EN】The invention relates to a method for producing 1,1, 1-trifluoro-2-chloroethane (HCFC-133a) and/or Trifluoroethylamine (TFEA), wherein at least one reaction step is carried out in a microreactor. In particular, a preferred embodiment of the invention relates to a method for producing 1,1, 1-trifluoro-2-chloroethane (HCFC-133a) and/or Trifluoroethylamine (TFEA), wherein at least one reaction step is carried out in a microreactor composed of or made of SiC ("SiC microreactor") or in a microreactor composed of or made of an alloy (e.g. Hastelloy C). In the manufacture of HCFC-133a and/or TFEA, HCFC-133a and/or TEFA can be readily purified and/or isolated, for example, by methods that use only low energy consumption, and preferably do not require distillation. Advantageously, HCFC-133a and/or TEFA can be easily separated from excess HF and catalyst in an energy efficient manner by phase separation.

摘要：【中文】本发明涉及一种口服葛根素混合胶束制剂、制备方法及其应用，该混合胶束制剂包括葛根素以及载体材料，所述载体材料由聚氧乙烯‑聚氧丙烯‑聚氧乙烯三嵌段聚合物与聚乙二醇羟基硬脂酸酯通过自组装的方式构成，所述葛根素与所述载体材料的质量比为(16:9)～(20:10)。本发明制备得到的口服葛根素混合胶束制剂，不仅可有效提高药葛根素的溶解度以及载药稳定性，并且能通过改善膜流动性以实现促渗的功能，进而提高葛根素的口服生物利用度。 【EN】The invention relates to an oral puerarin mixed micelle preparation, a preparation method and application thereof, wherein the mixed micelle preparation comprises puerarin and a carrier material, the carrier material is formed by a polyoxyethylene-polyoxypropylene-polyoxyethylene triblock polymer and polyethylene glycol hydroxystearate in a self-assembly mode, and the mass ratio of the puerarin to the carrier material is (16:9) - (20: 10). The oral puerarin mixed micelle preparation prepared by the invention not only can effectively improve the solubility and the drug-loading stability of the puerarin, but also can realize the function of promoting infiltration by improving the membrane fluidity, thereby improving the oral bioavailability of the puerarin.

摘要：【中文】本发明公开了一种基于仿生超滑表面的防污钛合金材料、其制备方法及应用。所述制备方法包括：采用阳极氧化法对钛合金基底进行处理，在所述钛合金基底表面形成阵列排列的纳米结构层，所述纳米结构层包含不同形貌和/或尺寸的纳米孔或纳米管；以氟硅烷修饰剂对具有纳米结构层的钛合金基底进行化学修饰；以及，向经化学修饰后的钛合金基底表面施加润滑剂，获得基于仿生超滑表面的防污钛合金材料。本发明的仿生超滑表面能够明显的降低细菌在钛合金表面的附着量，具有显著的抗细菌贴附作用和优异的缓释效果，同时其制备方法是一种绿色环保、高效防污的方法，在海洋防污领域具有更为广阔的应用前景。 【EN】The invention discloses an antifouling titanium alloy material based on a bionic super-smooth surface, and a preparation method and application thereof. The preparation method comprises the following steps: processing a titanium alloy substrate by adopting an anodic oxidation method, and forming a nanostructure layer arranged in an array on the surface of the titanium alloy substrate, wherein the nanostructure layer comprises nanopores or nanotubes with different shapes and/or sizes; chemically modifying the titanium alloy substrate with the nanostructure layer by using a fluorosilane modifier; and applying a lubricant to the surface of the chemically modified titanium alloy substrate to obtain the antifouling titanium alloy material based on the bionic super-smooth surface. The bionic super-smooth surface can obviously reduce the attachment amount of bacteria on the surface of the titanium alloy, has obvious antibacterial attachment effect and excellent slow release effect, and meanwhile, the preparation method is an environment-friendly and efficient antifouling method, and has wider application prospect in the field of marine antifouling.

摘要：【中文】本发明提供一种胆木浸膏缓释胶囊及其制备方法，缓释胶囊包括空心胶囊和填充在空心胶囊中质量比为1:0.95～1.05:0.95～1.05的快速释放丸、中速释放丸和慢速释放丸；以重量份数计，快速丸包括胆木浸膏粉120～140份、糊精60～80份和硬脂酸镁7～9份；中速丸包括胆木浸膏粉120～140份、羟丙基甲基纤维素30～50份、聚乙烯吡咯烷酮4～6份、糊精60～80份和硬脂酸镁7～9份；慢速丸包括胆木浸膏粉120～140份、羟丙基甲基纤维素60～100份、聚乙烯吡咯烷酮8～12份、糊精60～80份和硬脂酸镁7～9份。该胶囊能够持续释放药物，持续释药时间长；在体内缓慢释放，体内血药浓度较平稳。 【EN】The invention provides a nauclea officinalis extract sustained-release capsule and a preparation method thereof, wherein the sustained-release capsule comprises a hollow capsule and a quick-release pill, a medium-speed-release pill and a slow-release pill which are filled in the hollow capsule in a mass ratio of 1: 0.95-1.05; the fast-acting pill comprises, by weight, 120-140 parts of nauclea officinalis extract powder, 60-80 parts of dextrin and 7-9 parts of magnesium stearate; the medium-speed pill comprises 120-140 parts of nauclea officinalis extract powder, 30-50 parts of hydroxypropyl methyl cellulose, 4-6 parts of polyvinylpyrrolidone, 60-80 parts of dextrin and 7-9 parts of magnesium stearate; the slow-speed pill comprises 120-140 parts of nauclea officinalis extract powder, 60-100 parts of hydroxypropyl methyl cellulose, 8-12 parts of polyvinylpyrrolidone, 60-80 parts of dextrin and 7-9 parts of magnesium stearate. The capsule can release medicine continuously, and has long sustained release time; slowly released in vivo, and the blood concentration in vivo is relatively stable.

摘要：【中文】本发明涉及一种氟化气体的用途，其中单质氟(F2)优选以高浓度存在，例如单质氟(F2)的浓度尤其等于远远高于15体积％或甚至20体积％(即至少15体积％或甚至20体积％)，并涉及一种通过利用氟化气体直接氟化由苯甲酸衍生物开始制造氟化苯衍生物的工艺，其中单质氟(F2)优选以高浓度存在，随后通过直接氟化得到的苯甲酸次氟盐衍生物进行脱羧。本发明的工艺还涉及通过苯甲酸衍生物的直接氟化来制造苯甲酸次氟盐衍生物。特别地，在用于农业、制药、电子、催化剂、溶剂和其他功能性化学应用的氟化苯衍生物、终产物以及中间体的制备中，本发明令人关注。本发明的氟化工艺可以分批或以连续方式进行。 【EN】The present invention relates to the use of a fluorinated gas in which elemental fluorine (F2) is preferably present in high concentration, for example in a concentration especially equal to much higher than 15% or even 20% by volume (i.e. at least 15% or even 20% by volume) of elemental fluorine (F2), and to a process for the manufacture of fluorinated benzene derivatives starting from benzoic acid derivatives by direct fluorination using a fluorinated gas in which elemental fluorine (F2) is preferably present in high concentration, followed by decarboxylation of the hypofluorite derivatives of benzoic acid obtained by direct fluorination. The process of the present invention also relates to the manufacture of hypofluorite benzoate derivatives by direct fluorination of benzoic acid derivatives. In particular, the present invention is of interest in the preparation of fluorinated benzene derivatives, end products and intermediates for agricultural, pharmaceutical, electronic, catalyst, solvent and other functional chemical applications. The fluorination process of the present invention can be carried out in batch or in continuous mode.

摘要：【中文】本发明一种用于长期离体细胞太赫兹生物效应研究的系统及方法，所述系统包括密封固定装置、THz波发射装置、THz波传输装置、细胞外环境维持装置和探测装置；本发明针对贴壁生长的细胞培养物，设计构建了太赫兹波自下而上，长时程辐照细胞的系统与方法。一方面利用太赫兹波传输装置实现将太赫兹源发出的水平发散波改变为垂直汇聚波，该波束对于以薄塑料为基质的细胞培养材料有良好的透过性，因此可以穿过培养基质，作用于正常含有培养液的贴壁细胞生长物，避免了离体细胞周围的培养液对其的阻挡。另一方面利用可控温度样品室，实现细胞在辐照过程中始终处于接近孵箱培养的微环境中，保证长期辐照情况下细胞的存活需求。 【EN】The invention relates to a system and a method for researching a terahertz biological effect of a long-term in-vitro cell, wherein the system comprises a sealing and fixing device, a THz wave emitting device, a THz wave transmission device, an extracellular environment maintaining device and a detection device; the invention designs and constructs a system and a method for irradiating cells by terahertz waves from bottom to top for a long time aiming at cell cultures growing adherent. On one hand, the terahertz wave transmission device is utilized to change the horizontal divergent wave emitted by the terahertz source into the vertical convergent wave, and the wave beam has good permeability to cell culture materials taking thin plastic as a substrate, so that the wave beam can penetrate through the culture substrate to act on adherent cell growths normally containing culture solution, and the culture solution around isolated cells is prevented from blocking the adherent cell growths. On the other hand, the controllable temperature sample chamber is utilized to realize that the cells are always in a microenvironment close to incubator culture in the irradiation process, and the survival requirement of the cells under the long-term irradiation condition is ensured.

摘要：【中文】本发明公开了检测材料技术领域内的一种可快速可视化地鉴别混合有机溶剂浓度的形状记忆材料，其由聚苹果酸与2‑苯基‑1,3‑丙二醇交联反应获得，通过利用聚苹果酸与各种带不同的侧基的交联剂交联设计聚合物网络来调节对于不同溶剂的亲和性，达到快速可视化地来鉴别化学结构相似，性质相近的相似化合物。通过调节聚苹果酸侧基羧基在交联网络内的剩余量来控制形状记忆触发温度，做到在温和的条件下形状记忆可触发，以及赋予材料各种相似有机溶剂诱导的形状记忆能力。该形状记忆材料可运用于苯类、醇类的快速可视化的鉴别，包括不同苯类化合物的快速鉴别、假酒的鉴别、液体燃料纯度的鉴别等等。 【EN】The invention discloses a shape memory material capable of rapidly and visually identifying the concentration of a mixed organic solvent in the technical field of detection materials, which is obtained by crosslinking polymalic acid and 2-phenyl-1, 3-propylene glycol, and achieves rapid and visual identification of similar compounds with similar chemical structures and properties by utilizing a polymer network designed by crosslinking polymalic acid and various crosslinking agents with different side groups to adjust the affinity to different solvents. The shape memory triggering temperature is controlled by adjusting the residual amount of the polymalic acid side group carboxyl in the crosslinking network, so that the shape memory can be triggered under mild conditions, and the material is endowed with various similar organic solvent-induced shape memory capabilities. The shape memory material can be applied to the rapid visual identification of benzene and alcohol, including the rapid identification of different benzene compounds, the identification of fake wine, the identification of liquid fuel purity and the like.

摘要：【中文】本发明公开一种湿巾组合物。包括：外包装袋，在外包装袋内设置有湿巾用干布和薄膜密封袋，在薄膜密封袋内装有湿巾用液体；其中，湿巾用干布为易降解、水可冲散非织造布。本发明通过改变湿巾的组成结构，进行干湿分离，避免传统可冲散湿巾因湿态下断裂强力减弱，而影响生产效率，同时保持湿巾原本的特性，便于携带，利于清洁，改善产品置于高原地区时，因压差及高温引起的胀包漏液问题。 【EN】The invention discloses a wet tissue composition. The method comprises the following steps: the outer packaging bag is internally provided with dry cloth for wet tissues and a film sealing bag, and liquid for the wet tissues is filled in the film sealing bag; wherein, the dry cloth for the wet tissue is non-woven cloth which is easy to degrade and can be dispersed by water. The invention carries out dry-wet separation by changing the composition structure of the wet tissue, avoids the influence on the production efficiency caused by the weakening of the breaking strength of the traditional flushable wet tissue in a wet state, simultaneously keeps the original characteristics of the wet tissue, is convenient to carry and beneficial to cleaning, and improves the problem of bag expansion and liquid leakage caused by pressure difference and high temperature when the product is placed in a plateau area.