摘要：【中文】本发明公开了银杏萜内酯在制备预防、缓解或治疗肌萎缩侧索硬化药物中的应用，属于医药领域。银杏萜内酯选自白果内酯或银杏内酯B或银杏内酯A或银杏内酯C或银杏内酯M或银杏内酯J或银杏内酯K或银杏内酯L或银杏内酯N或银杏内酯P或银杏内酯Q中的一种或多种。本发明公开了银杏萜内酯组合物以及银杏萜内酯单体可不同程度改善ALS转基因小鼠运动功能，并且对雌鼠和雄鼠均有良好改善作用；本发明还公开了银杏萜内酯组合物、银杏内酯B、白果内酯可延缓ALS转基因小鼠发病时间，并且对雌鼠和雄鼠均有良好的延缓作用，因此可进一步用于预防、缓解或治疗哺乳动物肌萎缩侧索硬化。本发明为治疗肌萎缩侧索硬化提供一种新的、安全的药物选择。 【EN】The invention discloses an application of ginkgolide in preparing a medicine for preventing, relieving or treating amyotrophic lateral sclerosis, belonging to the field of medicines. The ginkgolide is selected from one or more of bilobalide or ginkgolide B or ginkgolide A or ginkgolide C or ginkgolide M or ginkgolide J or ginkgolide K or ginkgolide L or ginkgolide N or ginkgolide P or ginkgolide Q. The invention discloses a ginkgolide composition and a ginkgolide monomer which can improve the movement function of ALS transgenic mice to different degrees and have good improvement effect on female mice and male mice; the invention also discloses a ginkgolide composition, ginkgolide B and bilobalide which can delay the morbidity time of the ALS transgenic mice and have good delay effect on female mice and male mice, so that the ginkgolide composition can be further used for preventing, relieving or treating the amyotrophic lateral sclerosis of mammals. The invention provides a new and safe drug choice for treating amyotrophic lateral sclerosis.