摘要：【中文】本发明属于药物高分子载体制备和药物制剂技术领域，公开了一种酶敏感型两亲性聚酯载药纳米粒的制备方法。包括如下步骤：1)两亲性聚酯PET‑PCL‑Peptide的制备；2)MePEG‑COOH的制备；3)姜黄素与PET‑PCL‑Peptide加入至丙酮溶解形成油相，表面活性剂溶于水形成水相，将油相滴入水相，搅拌制备纳米粒；4)将3)制得的纳米粒溶液与一定浓度MePEG‑COOH溶液混合搅拌，得到平均粒径130～200nm，多分散指数(PDI)小于0.30，包封率大于70％的姜黄素‑纳米粒。该类纳米给药载体可作为一种载姜黄素缓释载体系统，采用亲水性外层MePEG‑COOH物理包裹亲脂性PET‑CPL‑Peptide内层成粒，使纳米粒具有靶向性强、生物利用度高、毒副作用小、稳定性强、提高姜黄素溶解性等优点，适用于静脉注射等多种给药方式。 【EN】The invention belongs to the technical field of preparation of drug polymer carriers and pharmaceutical preparations, and discloses a preparation method of an enzyme-sensitive amphiphilic polyester drug-loaded nanoparticle. The method comprises the following steps: 1) preparing amphiphilic polyester PET-PCL-Peptide; 2) preparing MePEG-COOH; 3) adding curcumin and PET-PCL-Peptide into acetone to dissolve to form an oil phase, dissolving a surfactant in water to form a water phase, dripping the oil phase into the water phase, and stirring to prepare nanoparticles; 4) mixing and stirring the nanoparticle solution prepared in the step 3) with a MePEG-COOH solution with a certain concentration to obtain curcumin-nanoparticles with the average particle size of 130-200 nm, the polydispersity index (PDI) of less than 0.30 and the encapsulation efficiency of more than 70%. The nano drug delivery carrier can be used as a curcumin-loaded slow release carrier system, and a hydrophilic outer layer MePEG-COOH is physically wrapped on a lipophilic PET-CPL-Peptide inner layer for granulation, so that the nano particles have the advantages of strong targeting property, high bioavailability, small toxic and side effects, strong stability, improvement of curcumin solubility and the like, and are suitable for various drug delivery modes such as intravenous injection and the like.

摘要：【中文】本发明涉及药物制剂技术领域，具体是涉及一种罗替戈汀鼻用胶束温敏凝胶的制备方法。将罗替戈汀和聚合物载体材料溶解于有机溶剂中形成有机相，将有机相缓慢滴加入纯水中，搅拌获得罗替戈汀聚合物胶束；然后向罗替戈汀聚合物胶束中加入温敏凝胶基质，混匀排尽气泡，制得罗替戈汀鼻用胶束温敏凝胶。本发明克服了罗替戈汀口服生物利用度极低、脂溶性强的缺点，结合聚合物胶束和温敏凝胶两者的优势，开发了鼻用罗替戈汀聚合物胶束温敏凝胶复合体系。聚合物胶束有效改善了罗替戈汀在水中的溶解性能，制成的罗替戈汀胶束温敏凝胶在温度较低时为溶液状态，在鼻腔温度下可快速转变成凝胶，利于制剂在鼻腔的黏附，药物生物利用度高，且脑靶向性良好。 【EN】The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation method of rotigotine nasal micelle temperature-sensitive gel. Dissolving rotigotine and a polymer carrier material in an organic solvent to form an organic phase, slowly dripping the organic phase into pure water, and stirring to obtain a rotigotine polymer micelle; and then adding a temperature-sensitive gel matrix into the rotigotine polymer micelle, uniformly mixing, and exhausting bubbles to obtain the rotigotine nasal micelle temperature-sensitive gel. The invention overcomes the defects of extremely low oral bioavailability and strong fat solubility of the rotigotine, combines the advantages of the polymer micelle and the temperature-sensitive gel, and develops the nasal rotigotine polymer micelle temperature-sensitive gel composite system. The polymer micelle effectively improves the solubility of the rotigotine in water, and the prepared rotigotine micelle temperature-sensitive gel is in a solution state at a lower temperature and can be quickly converted into gel at a nasal cavity temperature, so that the preparation is favorably adhered to the nasal cavity, the bioavailability of the medicine is high, and the brain targeting is good.

摘要：【中文】本发明公开了一种金/介孔硅/氧化铁纳米复合材料，将配体转换的氧化铁纳米晶分别修饰于氨基修饰的介孔硅包覆的金纳米棒的表面，形成核‑壳‑卫星结构；所述配体转换是指利用2‑溴代异丁酸进行配体转换；所述配体转换的氧化铁纳米晶的粒径为1～10nm；所述的金纳米棒的粒径为1～100nm；所述氨基修饰的介孔硅包覆的金纳米棒的粒径为5～500nm。本发明还公开了金/介孔硅/氧化铁纳米复合材料的制备方法和应用。该纳米复合材料能作为磁共振成像造影剂，用于体内的定位，确认最佳光照时间；在受到近红外光照射后，产热诱导胞内H₂O₂水平提升，激活芬顿反应杀伤三阴乳腺癌细胞。 【EN】The invention discloses a gold/mesoporous silicon/iron oxide nano composite material, wherein iron oxide nanocrystals converted by ligands are respectively modified on the surfaces of gold nanorods coated by mesoporous silicon modified by amino groups to form a core-shell-satellite structure; the ligand conversion is carried out by utilizing 2-bromoisobutyric acid; the particle size of the ligand-converted iron oxide nanocrystal is 1-10 nm; the particle size of the gold nanorods is 1-100 nm; the particle size of the amino-modified mesoporous silicon-coated gold nanorod is 5-500 nm. The invention also discloses a preparation method and application of the gold/mesoporous silicon/ferric oxide nanocomposite. The nano composite material can be used as a magnetic resonance imaging contrast agent for positioning in vivo,confirming the optimal illumination time; generates heat to induce intracellular H after being irradiated by near infrared light₂O₂The level is increased, and Fenton reaction is activated to kill triple-negative breast cancer cells.

摘要：【中文】本发明公开了一种标签数据处理系统和方法，涉及数据处理技术。标签数据处理系统，包括：网关，被配置为获取来自客户端的数据处理请求；以及，根据服务标识将数据处理请求转发给相应的服务模块；应用服务器，包括多个服务模块，被配置为将获取的数据处理请求转换为计算请求并发送给相应的计算模块，在数据处理请求为预设类型的处理请求的情况下，将计算请求发送给内存计算集群；将计算结果作为数据处理响应返回给用户；内存计算集群，被配置为响应于获取计算请求，从缓存集群中读取标签数据并进行计算；以及将计算结果返回给应用服务器；缓存集群，被配置为存储标签数据。从而提高了计算和响应速度以及对标签数据的处理效率。 【EN】The invention discloses a tag data processing system and a tag data processing method, and relates to the data processing technology. A tag data processing system, comprising: the gateway is configured to acquire a data processing request from the client; and forwarding the data processing request to the corresponding service module according to the service identifier; the application server comprises a plurality of service modules and is configured to convert the acquired data processing requests into calculation requests and send the calculation requests to corresponding calculation modules, and the calculation requests are sent to the memory calculation cluster under the condition that the data processing requests are processing requests of a preset type; returning the calculation result to the user as a data processing response; the memory computing cluster is configured to respond to the acquired computing request, read the tag data from the memory cluster and perform computing; and returning the calculation result to the application server; a cache cluster configured to store tag data. Thereby improving the calculation and response speed and the processing efficiency of the tag data.

摘要：【中文】一种催化裂化废催化剂的回收利用方法及应用，1)用水配置亚铁盐溶液，其中亚铁离子的浓度为0.01mol/L～1mol/L，向配置好的亚铁盐溶液中加入一定质量的催化裂化废催化剂并均匀搅拌，形成溶液A；2)向上述溶液A中通入过量的空气或者氧气，加入碱溶液并搅拌均匀，通过加入碱溶液的含量控制反应过程pH值在4.0～7.0，反应0.4～5h，反应温度为10～60摄氏度；所述碱溶液为含有氢氧根离子的强碱或者弱碱；3)反应结束后出料，脱水并干燥，得到活性组分为α‑FeOOH的负载型催化剂。该方法生产制备方式简单，成本低廉，环境污染小且易于工业化，能够实现资源的有效循环利用。 【EN】A method for recycling catalytic cracking waste catalyst comprises the steps of 1) preparing a ferrous salt solution with ferrous ions of 0.01-1 mol/L by water, adding a certain mass of catalytic cracking waste catalyst into the prepared ferrous salt solution, uniformly stirring to form a solution A, 2) introducing excessive air or oxygen into the solution A, adding an alkali solution into the solution A, uniformly stirring, controlling the pH value in the reaction process to be 4.0-7.0 by adding the alkali solution, reacting for 0.4-5 h at the reaction temperature of 10-60 ℃, wherein the alkali solution is strong alkali or weak alkali containing hydroxide ions, and 3) discharging, dehydrating and drying after the reaction is finished to obtain the supported catalyst with an active component of α -FeOOH.

摘要：【中文】本发明公开了一种罗非鱼与南美白对虾混养方法，S1、放苗前的准备工作：清污整池，消毒除害，杀灭池塘内的敌害生物，然后安装进、排水过滤网和围网标粗，安装结束后，进行放水，对水体进行消毒；S2、水体培育：水体消毒3天后，将肥料用水溶解后均匀泼洒在水面，追肥可每天施肥1次，连续进行，直到池水透明度为25cm左右时停止，肥水后，在放苗前2天施用益微生物制剂，以保持水体微生态环境的平衡；本发明将罗非鱼与南美白对虾进行混合养殖前，对罗非鱼进行初次消毒和杀菌，减少罗非鱼携带的病菌，有助于降低病害，提高鱼虾的成活率，且本发明使用的消毒溶剂，消毒效果好，且对鱼苗本身伤害小。 【EN】The invention discloses a method for polyculture of tilapia and penaeus vannamei boone, which comprises the following steps of S1, preparation work before stocking: cleaning the sewage, sterilizing, removing harm, killing harmful organisms in the pond, installing a water inlet and drainage filter screen and a purse net with thick marks, and draining water after the installation is finished to sterilize a water body; s2, water cultivation: after 3 days of water body disinfection, fertilizer is uniformly sprayed on the water surface after being dissolved by water, topdressing can be continuously carried out for 1 time every day until the transparency of pool water is about 25cm, and after water fertilization, a probiotic preparation is applied 2 days before seedling placement to keep the balance of the water body micro-ecological environment; before mixed culture of tilapia and penaeus vannamei boone, the tilapia is subjected to primary disinfection and sterilization, germs carried by the tilapia are reduced, diseases are reduced, and the survival rate of the fish and the shrimp is improved.

摘要：【中文】本发明公开一种鲨鱼鳍天线电路以及鲨鱼鳍天线，包括：AM/FM无源天线体、调制信号AM/FM电路、电源管理单元和导航信号GPS/BD电路；导航信号GPS/BD电路包括：GPS/BD无源天线体、低噪滤波单元、第一滤波阻抗单元以及导航信号GPS/BD输入端。通过将第一滤波阻抗单元输出的一路GPS/BD信号与调制信号AM/FM电路输出的AM/FM信号合并为一路信号通过调制信号AM/FM输入端进行输出，将第一滤波阻抗单元输出的另一路GPS/BD信号通过导航信号GPS/BD输入端进行输出，能够减少一路GPS/BD信号的传输线束，从而能够在不减少鲨鱼鳍天线集成功能的情况下，降低鲨鱼鳍天线的生产成本。 【EN】The invention discloses a shark fin antenna circuit and a shark fin antenna, comprising: the system comprises an AM/FM passive antenna body, a modulation signal AM/FM circuit, a power supply management unit and a navigation signal GPS/BD circuit; the navigation signal GPS/BD circuit comprises: the GPS/BD passive antenna comprises a GPS/BD passive antenna body, a low-noise filtering unit, a first filtering impedance unit and a navigation signal GPS/BD input end. One path of GPS/BD signals output by the first filtering impedance unit and one path of AM/FM signals output by the modulation signal AM/FM circuit are combined into one path of signals to be output through the modulation signal AM/FM input end, and the other path of GPS/BD signals output by the first filtering impedance unit are output through the navigation signal GPS/BD input end, so that the transmission wire harness of one path of GPS/BD signals can be reduced, and the production cost of the shark fin antenna can be reduced under the condition that the shark fin antenna integration function is not reduced.

摘要：【中文】本发明公开了一种基于车联网平台的日志管理方法、设备、存储介质及装置，该方法包括：获取车载系统日志文件的文件数量，在所述文件数量满足预设值时，将所述日志文件进行压缩打包，获得日志压缩包；接收远程指令，从所述远程指令中提取需上传的压缩包数量；根据所述压缩包数量，按照预设上传规则将所述日志压缩包上传至文件传输协议服务器。本发明中，日志文件全部存储到服务器，可通过远程指令控制日志文件上传，从而实现远程分析解决车辆故障问题。 【EN】The invention discloses a log management method, a device, a storage medium and a device based on a vehicle networking platform, wherein the method comprises the following steps: acquiring the number of files of a log file of a vehicle-mounted system, and compressing and packaging the log file to obtain a log compression packet when the number of files meets a preset value; receiving a remote instruction, and extracting the number of compressed packets to be uploaded from the remote instruction; and uploading the log compressed packets to a file transfer protocol server according to the number of the compressed packets and a preset uploading rule. In the invention, all the log files are stored in the server, and the log files can be uploaded under the control of a remote instruction, so that the problem of vehicle faults can be solved through remote analysis.

摘要：【中文】本发明公开了一种车载收音机的切换方法、装置、存储介质及设备，该方法包括：获取车载收音机的锁台灵敏度和信噪比，根据所述锁台灵敏度和所述信噪比设置当前搜索标准；根据所述当前搜索标准，搜索电台的当前信号强度；获取所述车载收音机所在目标车辆的标定信号强度；根据所述当前信号强度和所述标定信号强度，判断所述车载收音机的目标模式；将所述车载收音机的搜索模式切换至所述目标模式。本发明中，通过根据电台的当前信号强度和目标车辆的标定信号强度，选择利于电台接收效果的目标模式，避免收音信号受天气或建筑物遮挡等外部因素影响，导致的收听效果不好的情况，从而保证收听的电台的收音效果稳定性，提高用户体验。 【EN】The invention discloses a switching method, a device, a storage medium and equipment of a vehicle-mounted radio, wherein the method comprises the following steps: acquiring the lock sensitivity and the signal-to-noise ratio of the vehicle-mounted radio, and setting a current search standard according to the lock sensitivity and the signal-to-noise ratio; searching the current signal intensity of the radio station according to the current search standard; acquiring the strength of a calibration signal of a target vehicle where the vehicle-mounted radio is located; judging a target mode of the vehicle-mounted radio according to the current signal intensity and the calibrated signal intensity; and switching the search mode of the vehicle-mounted radio to the target mode. According to the invention, the target mode which is beneficial to the receiving effect of the radio station is selected according to the current signal intensity of the radio station and the calibrated signal intensity of the target vehicle, so that the condition that the receiving effect is poor due to the fact that the receiving signal is influenced by external factors such as weather or building shielding is avoided, the stability of the receiving effect of the received radio station is ensured, and the user experience is improved.

摘要：【中文】本申请实施例提供一种切片信息处理方法及装置，涉及通信技术领域，尤其涉及一种切片信息处理方法及装置，用以保障每个切片内终端的业务体验在不同的MOS分区间得到满足。该方案包括：管理控制功能网元向数据分析功能网元发送第一请求，所述第一请求用于请求至少一个切片组成的切片网络的第一信息，所述第一请求包括：所述至少一个切片的标识信息；所述管理控制功能网元接收所述数据分析功能网元发送的第一响应，所述第一响应包括所述第一信息，其中，所述第一信息用于所述至少一个切片中每个切片的用户控制或业务控制中的至少一个。 【EN】The embodiment of the application provides a slice information processing method and device, relates to the technical field of communication, and particularly relates to a slice information processing method and device, which are used for ensuring that service experience of a terminal in each slice is met between different MOS partitions. The scheme comprises the following steps: the management control function network element sends a first request to a data analysis function network element, where the first request is used to request first information of a slice network composed of at least one slice, and the first request includes: identification information of the at least one slice; the management control function network element receives a first response sent by the data analysis function network element, where the first response includes the first information, and the first information is used for at least one of user control or service control of each slice in the at least one slice.