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Zhai Xiaoling
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[发明]
【中文】巴比妥酸衍生物修饰的二硫化钼二维纳米材料及其应用 【EN】Barbituric acid derivative modified molybdenum disulfide two-dimensional nano material and application thereof
申请号:
201911162503.8
公开号:CN110859962A 主分类号:A61K47/02
申请人:
【中文】山东大学【EN】SHANDONG University
申请日:2019.11.25 公开日:2020.03.06
发明人:
【中文】翟淑梅
;
王小玲
;
闫兵
;
王深清
;
江翠娟【EN】Zhai Shumei
;
Wang Xiaoling
;
Yan Bing
;
Wang Shenqing
;
Jiang Cuijuan
摘要:【中文】本发明公开了一类具有多样化亲疏水性质和电荷的硫代巴比妥酸衍生物类分子修饰的二硫化钼二维纳米材料,是式(Ⅰ)至式(IX)所示的Ligand 1~Ligand 9配体分子化合物分别修饰的二硫化钼纳米材料,依次命名为MoS
2
‑1~MoS
2
‑9。本发明还公开了所述二硫化钼纳米材料在制备抑制肿瘤细胞生长药物、药物载体、或作为药物载体在制备抑制肿瘤细胞生长的负载紫杉醇的药物复合物中的应用。实验证实本发明的具有多样化亲疏水性质和电荷的硫代巴比妥酸衍生物类分子修饰的二硫化钼二维纳米材料有望成为肿瘤协同治疗的有潜力药物或药物载体,具有广阔的科研和临床应用前景。 【EN】The inventionDiscloses a thiobarbituric acid derivative molecule modified molybdenum disulfide two-dimensional nano material with diversified hydrophilic and hydrophobic properties and charges, which is a molybdenum disulfide nano material respectively modified by Ligand molecule compounds of Ligand 1-Ligand 9 shown in formulas (I) to (IX), and is sequentially named as MoS
2
‑1~MoS
2
-9. The invention also discloses application of the molybdenum disulfide nano material in preparing a medicine for inhibiting tumor cell growth, a medicine carrier or a medicine carrier in preparing a taxol-loaded medicine compound for inhibiting tumor cell growth. Experiments prove that the thiobarbituric acid derivative molecule-modified molybdenum disulfide two-dimensional nano material with diversified hydrophilic and hydrophobic properties and charges is expected to become a potential drug or drug carrier for tumor synergistic treatment, and has wide scientific research and clinical application prospects.
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2:
[发明]
【中文】一种大规模糯性小麦籽粒鉴定的统筹方法 【EN】Overall planning method for large-scale waxy wheat grain identification
申请号:
201911328096.3
公开号:CN111007019A 主分类号:G01N21/25
申请人:
【中文】青岛市农业科学研究院【EN】QINGDAO ACADEMY OF AGRICULTURAL SCIENCES
申请日:2019.12.20 公开日:2020.04.14
发明人:
【中文】盖红梅
;
翟晓灵
;
李玉刚
;
宋朝玉
;
王圣健
;
宫明波
;
王瑞英【EN】Gai Hongmei
;
Zhai Xiaoling
;
Li Yugang
;
Song Chaoyu
;
Wang Shengjian
;
Gong Mingbo
;
Wang Ruiying
摘要:【中文】一种大规模糯性小麦籽粒鉴定的统筹方法,小麦籽粒进行横切,切面远离具胚端;具胚端的横切面进行碘‑碘化钾溶液轻染色,并将染色后的浮于具胚端表面的溶液吸干,再进行烘干;烘干后的所述具胚端通过专业人员进行颜色鉴定,保留糯性籽粒,将染色的所述具胚端直接播种并进行后期的农艺性状调查。本发明所述的大规模糯性小麦籽粒鉴定的统筹方法,大大节省了小麦籽粒的保存空间,而且避免了将小麦籽粒对照混乱造成失误;而且更有利于颜色的显示,减少了显色误差;烘干处理可以使颜色鉴别时更为方便,更便于所述具胚端的保存,减少保存过程中造成的籽粒发芽或籽粒腐烂的状况发生,从而大大提高了糯性小麦鉴定的效率。 【EN】A comprehensive method for large-scale waxy wheat grain identification comprises transversely cutting wheat grains, wherein the cut surface is far away from an embryo end; lightly dyeing the cross section with the embryo end with iodine-potassium iodide solution, sucking the dyed solution floating on the surface with the embryo end, and drying; and (3) carrying out color identification on the dried embryo-bearing end by a professional, reserving waxy grains, directly sowing the dyed embryo-bearing end, and carrying out later-stage agronomic character investigation. The overall method for identifying the large-scale waxy wheat grains greatly saves the storage space of the wheat grains and avoids errors caused by disordered contrast of the wheat grains; moreover, the color display is facilitated, and the color rendering error is reduced; the drying treatment can make the color identification more convenient, the preservation of the germ end is more convenient, and the seed germination or seed decay condition caused in the preservation process is reduced, thereby greatly improving the efficiency of the waxy wheat identification.
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