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Zhang Fangnan
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1:
[发明]
【中文】致密油气储层流体因子检测油气储层的方法及设备 【EN】Method and equipment for detecting oil and gas reservoir by fluid factor of tight oil and gas reservoir
申请号:
201911327436.0
公开号:CN111077568A 主分类号:G01V1/28
申请人:
【中文】中国石油大学(北京)
;
中国石油集团科学技术研究院有限公司【EN】China University of Petroleum (Beijing)
;
CHINA NATIONAL PETROLEUM CORPORATION SCIENCE AND TECHNOLOGY RESEARCH INSTITUTE Co.,Ltd.
申请日:2019.12.20 公开日:2020.04.28
发明人:
【中文】李生杰
;
康永尚
;
赵群
;
王红岩
;
张方南【EN】Li Shengjie
;
Kang Yongshang
;
Zhao Qun
;
Wang Hongyan
;
Zhang Fangnan
摘要:【中文】本发明实施例提供一种致密油气储层流体因子检测油气储层的方法及设备,该方法包括:根据实际的致密储层的岩心样品及其测试数据,构建致密砂岩的基质模量预测模型;根据实测的岩心孔隙度和声波速度,采用胶结砂岩理论,构建致密储层干燥状况下岩石物理模型;采用Gassmann方程,结合干燥致密砂岩岩石物理模型的预测结果,进行流体替换分析和拉梅模量相关参数转换,并进行拉梅模量相关参数的流体敏感性分析;根据流体替换计算的属性参数,结合实际钻测井资料,确定等效流体因子;采用地震反演方法获取目的层的弹性参数,结合测井资料,计算地震流体因子数据体;根据新构建的地震流体因子进行地震流体检测分析,预测地震油气储层的分布。 【EN】The embodiment of the invention provides a method and equipment for detecting a hydrocarbon reservoir by using a fluid factor of a tight hydrocarbon reservoir, wherein the method comprises the following steps: constructing a matrix modulus prediction model of the tight sandstone according to the actual core sample of the tight reservoir and the test data thereof; according to the actually measured core porosity and sound wave speed, a rock physical model under the dry condition of a compact reservoir is constructed by adopting a cemented sandstone theory; adopting a Gassmann equation, and combining the prediction result of the dry compact sandstone rock physical model to perform fluid replacement analysis and conversion of parameters related to the Lame modulus, and performing fluid sensitivity analysis of the parameters related to the Lame modulus; determining an equivalent fluid factor according to the attribute parameters of fluid replacement calculation and by combining actual drilling logging information; acquiring elastic parameters of a target layer by adopting a seismic inversion method, and calculating a seismic fluid factor data volume by combining logging data; and performing seismic fluid detection analysis according to the newly constructed seismic fluid factor to predict the distribution of the seismic oil and gas reservoir.
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2:
[发明]
【中文】负载抗癌药物的载药体系及其制备和应用 【EN】Medicine carrying system for loading anticancer medicine and preparation and application thereof
申请号:
202010052562.6
公开号:CN111084759A 主分类号:A61K9/127
申请人:
【中文】福建师范大学【EN】Fujian Normal University
申请日:2020.01.17 公开日:2020.05.01
发明人:
【中文】吴允昆
;
肖方南
;
陈方满
;
张维彬【EN】Wu Yunkun
;
Xiao Fangnan
;
Chen Fangman
;
Zhang Weibin
摘要:【中文】本发明涉及涉及纳米医药技术领域,具体涉及一种负载抗癌药物的载药体系及其制备和应用。采用生物相容性好、比表面积大的介孔二氧化硅纳米球与小分子配合物所构成的载药颗粒作为内核层,在其外表面包覆含有特定靶蛋白和脂质体膜构成的脂质体层,由于特定靶蛋白(由H1299.2靶肽,e‑GFP和MscL的融合构建、表达)与脂质体膜融合而成,在作为抗癌化疗药物进入机体后,在无靶蛋白结合位点的正常组织内不积累,在有靶位的肿瘤细胞上结合定点释放药物。由于特定靶蛋白上含有荧光蛋白e‑GFP,可以通过测定e‑GFP的荧光值来测定其在体内的分布,从而可以更加精确地指导化疗用药。 【EN】The invention relates to the technical field of nano-medicine, in particular to a medicine carrying system for carrying an anti-cancer medicine, and preparation and application thereof. The drug-carrying particles formed by mesoporous silica nanospheres with good biocompatibility and large specific surface area and small molecular complexes are used as an inner core layer, the outer surface of the drug-carrying particles is coated with a liposome layer formed by specific target protein and a liposome membrane, and the specific target protein (formed by fusion construction and expression of H1299.2 target peptide, e-GFP and MscL) is fused with the liposome membrane, so that after the drug-carrying particles as an anti-cancer chemotherapeutic drug enter an organism, the drug-carrying particles are not accumulated in normal tissues without target protein binding sites, and the drug is bound on tumor cells with target sites and released at fixed points. Since the specific target protein contains the fluorescent protein e-GFP, the distribution of the e-GFP in the body can be determined by measuring the fluorescence value of the e-GFP, so that the chemotherapy can be guided more accurately.
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3:
[发明]
【中文】一种大黄鱼口服纳米疫苗及其制备方法与应用 【EN】Oral nano vaccine for large yellow croaker and preparation method and application thereof
申请号:
201911327322.6
公开号:CN110935016A 主分类号:A61K39/106
申请人:
【中文】福建师范大学【EN】Fujian Normal University
申请日:2019.12.20 公开日:2020.03.31
发明人:
【中文】吴允昆
;
朱春华
;
张维彬
;
肖方南
;
王前超
;
张娜【EN】Wu Yunkun
;
Zhu Chunhua
;
Zhang Weibin
;
Xiao Fangnan
;
Wang Qianchao
;
Zhang Na
摘要:【中文】本发明涉及一种大黄鱼口服纳米疫苗以及由所述大黄鱼口服纳米疫苗制备的免疫型大黄鱼饲料,所述大黄鱼口服纳米疫苗,它包括MSN‑DLDH纳米颗粒以及包覆于MSN‑DLDH纳米颗粒表面的肠溶包衣;所述MSN‑DLDH纳米颗粒为DLDH蛋白与介孔二氧化硅微纳米运载体系组装成的纳米颗粒;所述肠溶包衣为羟丙基甲基纤维素邻苯二甲酸酯。本发明的纳米疫苗具有成本低、制备工艺简单、能耐受鱼类强酸性胃部环境等优点;此外,该疫苗对大黄鱼肾细胞没有毒性,生物兼容性好,这为将来口服纳米疫苗研发并走向临床应用提供了技术支撑。 【EN】The invention relates to a large yellow croaker oral nano vaccine and an immune type large yellow croaker feed prepared from the large yellow croaker oral nano vaccine, wherein the large yellow croaker oral nano vaccine comprises MSN-DLDH nano particles and an enteric coating coated on the surfaces of the MSN-DLDH nano particles; the MSN-DLDH nano-particles are nano-particles assembled by DLDH protein and mesoporous silica micro-nano carrying systems; the enteric coating is hydroxypropyl methyl cellulose phthalate. The nano vaccine has the advantages of low cost, simple preparation process, capability of tolerating the strong acid stomach environment of fishes and the like; in addition, the vaccine has no toxicity to kidney cells of the large yellow croaker and good biocompatibility, thereby providing technical support for the development and clinical application of oral nano-vaccine in the future.
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4:
[发明]
【中文】一种±800kV输变电主设备空载试验用陷波装置 【EN】Trap device for no-load test of +/-800 kV power transmission and transformation main equipment
申请号:
201911227378.4
公开号:CN110865216A 主分类号:G01R1/28
申请人:
【中文】国网青海省电力公司电力科学研究院
;
青海电研科技有限责任公司
;
国网青海省电力公司
;
国家电网有限公司【EN】Electric Power Research Institute of State Grid Qinghai Electric Power Company
;
Qinghai Dianyan Technology Co., Ltd.
;
State Grid Qinghai Electric Power Company
;
STATE GRID CORPORATION OF CHINA
申请日:2019.12.04 公开日:2020.03.06
发明人:
【中文】王生杰
;
王理丽
;
于鑫龙
;
王生富
;
沈洁
;
林万德
;
杨放南
;
马旭东
;
包正红
;
张成磊
;
蒋玲
;
李占林
;
李渊
;
宋琳【EN】Wang Shengjie
;
Wang Lili
;
Yu Xinlong
;
Wang Shengfu
;
Shen Jie
;
Lin Wande
;
Yang Fangnan
;
Ma Xudong
;
Bao Zhenghong
;
Zhang Chenglei
;
Jiang Ling
;
Li Zhanlin
;
Li Yuan
;
Song Lin
摘要:【中文】一种±800kV输变电主设备空载试验用陷波装置,涉及电气试验设备技术领域,其结构为:由3次谐波滤波器和5次谐波滤波器并联组成;3次谐波滤波器和5次谐波滤波器均由电容器组和电抗器串联组成。本发明的有益效果在于:本发明的使用,电压波形校正因素d的绝对值和电压波形畸变率THD均会大幅度减小,能够满足标准要求使得电压波形校正因素d小于等于±3%,3次谐波滤波器和5次谐波滤波器并联使用,能够很明显的减少试验电源的容量,对于现场试验有很大的辅助作用。 【EN】The utility model provides a +/-800 kV power transmission and transformation main equipment is trapped wave device for no-load test, relates to electrical test equipment technical field, and its structure is: the filter is formed by connecting a 3-order harmonic filter and a 5-order harmonic filter in parallel; the 3 rd harmonic filter and the 5 th harmonic filter are both formed by connecting a capacitor bank and a reactor in series. The invention has the beneficial effects that: when the voltage waveform correction factor d is used, the absolute value of the voltage waveform correction factor d and the voltage waveform distortion rate THD are both greatly reduced, the standard requirement can be met, the voltage waveform correction factor d is less than or equal to +/-3%, the 3-order harmonic filter and the 5-order harmonic filter are used in parallel, the capacity of a test power supply can be obviously reduced, and the auxiliary effect on a field test is realized.
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