摘要：【中文】本发明涉及新型纳米硒的快速制备，具体涉及一种功能化纳米硒水溶胶及其制备方法与应用。本发明所述的新型纳米硒水溶胶制备方法包括以下步骤:(i)向虫草菌丝体Cs4多糖蛋白溶液中加入二氧化硒溶液或亚硒酸盐溶液,混合均匀,得到混合溶液A；所述的虫草菌丝体Cs4多糖蛋白溶液是通过水提虫草菌丝体Cs4得到；(ii)向混合溶液A中加入维生素C溶液,混匀,得到混合溶液B；(iii)待混合溶液B反应完全,经过透析得到纳米硒水溶胶。本发明以具有广泛生物活性的虫草菌丝体Cs4多糖蛋白作为纳米硒功能化因子,获得一种具有促进骨骼生长功能且稳定性好的新型纳米硒水溶胶,可用于儿童青少年期促进骨发育以及中年期防治骨质疏松症、骨流失、骨折等疾病状态。 【EN】The invention relates to rapid preparation of novel nano-selenium, in particular to a functionalized nano-selenium hydrosol and a preparation method and application thereof. Adding a selenium dioxide solution or a selenite solution into a cordyceps mycelium Cs4 polysaccharide protein solution, and uniformly mixing to obtain a mixed solution A; the cordyceps mycelia Cs4 polysaccharide protein solution is obtained by water extraction of cordyceps mycelia Cs 4; (ii) adding the vitamin C solution into the mixed solution A, and uniformly mixing to obtain a mixed solution B; (iii) and after the mixed solution B completely reacts, dialyzing to obtain the nano-selenium hydrosol. The invention takes cordyceps mycelium Cs4 polysaccharide protein with wide biological activity as a nano-selenium functional factor to obtain a novel nano-selenium hydrosol with the function of promoting the growth of bones and good stability, which can be used for promoting the development of bones in the adolescent period of children and preventing and treating diseases such as osteoporosis, bone loss, fracture and the like in the middle-aged period.