摘要：【中文】本发明公开了一种长链多肽的固相合成方法，该发明使用了一种多功能反应釜，该反应釜包括底座、反应釜体、储液槽，在反应釜体顶部设有喷淋层，将液态反应物通过喷洒的方式加入反应釜中，同时反应釜中的固态粉末状物料进行搅拌，使得液态反应物和固态粉末状物料的接触面积增大，提升了反应速率，锦进一步提升了长链多肽的制备效率，多肽合成只在一个反应容器中进行，完全避免了在反应过程中转移反应物造成反应物污染的情况，从而保证了多肽的纯度，且该方法制备的长链多肽氨基酸的副反应较少，副反应产物较少，进一步保证了制备的长链多肽的纯度。 【EN】The invention discloses a solid phase synthesis method of long-chain polypeptide, which uses a multifunctional reaction kettle, wherein the reaction kettle comprises a base, a reaction kettle body and a liquid storage tank, a spraying layer is arranged at the top of the reaction kettle body, a liquid reactant is added into the reaction kettle in a spraying mode, and meanwhile, solid powdery materials in the reaction kettle are stirred, so that the contact area between the liquid reactant and the solid powdery materials is increased, the reaction rate is improved, the preparation efficiency of the long-chain polypeptide is further improved, the polypeptide synthesis is only carried out in one reaction container, the condition of reactant pollution caused by transferring the reactant in the reaction process is completely avoided, the purity of the polypeptide is ensured, the side reaction of the long-chain polypeptide amino acid prepared by the method is less, the side reaction products are less, and the purity of the prepared long-chain polypeptide is further ensured.