摘要：【中文】本发明属于化学合成技术领域，具体涉及一种化合物及其制备方法。所述化合物为3‑[[(4‑甲基‑1‑哌嗪基)亚氨基]甲基]‑17‑(1‑羟基甲氧基)利福霉素，所述制备方法为以3‑[[(4‑甲基‑1‑哌嗪基)亚氨基]甲基]利福霉素为原料，在溶剂中通过缩合反应得到3‑[[(4‑甲基‑1‑哌嗪基)亚氨基]甲基]‑17‑(1‑羟基甲氧基)利福霉素，然后加入低极性溶剂进行纯化。所述方法具有合成路线短、纯化快速简便、所得产品纯度高的特点，可以用于利福平生产中杂质的定性和定量分析，从而提高利福平的质量标准，从而为安全用药提供重要的指导意义。 【EN】The invention belongs to the technical field of chemical synthesis, and particularly relates to a compound and a preparation method thereof. The compound is 3- [ [ (4-methyl-1-piperazinyl) imino ] methyl ] -17- (1-hydroxymethoxy) rifamycin, the preparation method comprises the steps of taking 3- [ [ (4-methyl-1-piperazinyl) imino ] methyl ] rifamycin as a raw material, carrying out condensation reaction in a solvent to obtain the 3- [ [ (4-methyl-1-piperazinyl) imino ] methyl ] -17- (1-hydroxymethoxy) rifamycin, and then adding a low-polarity solvent for purification. The method has the characteristics of short synthetic route, quick and simple purification and high purity of the obtained product, and can be used for qualitative and quantitative analysis of impurities in rifampicin production, so that the quality standard of rifampicin is improved, and important guiding significance is provided for safe medication.

摘要：【中文】本发明属于化学合成技术领域，具体涉及一种化合物的制备方法。所述化合物为1,2‑二[3,5‑二(2‑氰基异丙基)苯基]乙烷，所述制备方法为以5‑卤代甲基‑1,3‑苯二乙腈为原料通过格氏反应制备得到。所述方法具有合成路线短、操作简便，所得产品纯度高，便于对照品研究等特点，可以用于阿那曲唑生产中杂质的定性和定量分析，从而提高阿那曲唑的质量标准，从而为安全用药提供重要的指导意义。 【EN】The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of a compound. The compound is 1, 2-bis [3, 5-bis (2-cyanoisopropyl) phenyl ] ethane, and the preparation method is characterized in that 5-halogenated methyl-1, 3-benzene diacetonitrile is used as a raw material and is prepared through Grignard reaction. The method has the characteristics of short synthetic route, simple and convenient operation, high purity of the obtained product, convenience for reference substance research and the like, and can be used for qualitative and quantitative analysis of impurities in anastrozole production, so that the quality standard of anastrozole is improved, and important guiding significance is provided for safe medication.